Interleukin-36 Is Highly Expressed in Skin Biopsies from Two Patients with Netherton Syndrome [0.03%]
奈特赫顿综合征患者皮肤活检标本中白细胞介素-36高表达
Johannes Pawlowski,Tatsiana Pukhalskaya,Kelly Cordoro et al.
Johannes Pawlowski et al.
Netherton syndrome (NS) is a rare autosomal recessive disorder that occurs due to a loss-of-function mutation in SPINK5; this loss results in significant inflammation, as well as perturbations of the skin barrier's integrity and functionali...
IgG4-Related Disease (IgG4-RD) with Unique Combined Generalized Skin Rashes and Biliary Tract Manifestation: A Comprehensive Immunological Analysis [0.03%]
独特并发全身性皮疹和胆道受累的IgG4相关性疾病（IgG4-RD）的全面免疫学分析
Ye La Jung,Sudhanshu Agrawal,Beverly Wang et al.
Ye La Jung et al.
IgG4-RD is a multisystem fibroinflammatory disease characterized by the infiltration of tissues by IgG4 plasma cells. Combined skin and biliary tract involvement in IgG4-RD has not been described. We present perhaps the most comprehensive a...
The Rarity in the Rarity: Presentation of Three Cases of Cutaneous Carcinosarcoma with Clinical and Histopathological Insights [0.03%]
罕见中的罕见：三例具有临床及病理意义的皮肤 carcinosarcoma 病例报道
Gerardo Cazzato,Anna Colagrande,Valentina Caputo et al.
Gerardo Cazzato et al.
A cutaneous carcinosarcoma (cCS) is a rare and aggressive skin cancer characterized by both carcinomatous (epithelial) and sarcomatous (mesenchymal) components, making it a biphasic tumor. Despite its occurrence in various organs, a cCS is ...
TRPS1 Expression Is Frequently Seen in a Subset of Cutaneous Mesenchymal Neoplasms and Tumors of Uncertain Differentiation: A Potential Diagnostic Pitfall [0.03%]
TRPS1在一部分皮肤间叶源性肿瘤及分化不明肿瘤中的表达：潜在的诊断陷阱
Moon Joo Kim,Yi A Liu,Yunyi Wang et al.
Moon Joo Kim et al.
Although extensively studied in cutaneous epithelial neoplasms, the TRPS1 immunoreactivity in cutaneous mesenchymal neoplasms and tumors of uncertain differentiation (CMNTUDs), such as atypical fibroxanthoma (AFX), remains largely unexplore...
Placental ACE2 Expression: A Possible Pathogenetic Mechanism for Infantile Hemangiomas [0.03%]
胎盘ACE2的表达：婴幼儿血管瘤的一个可能发病机制
Aurora De Marco,Gerardo Cazzato,Rosalba Maggialetti et al.
Aurora De Marco et al.
ACE2 is a mono-carboxypeptidase with remarkable vasculo-protective properties, and its expression in the human placenta plays a central role in blood pressure homeostasis and fetal perfusion. Therefore, an alteration in the placental expres...
Histopathologic Evaluation of Atypical Fibroxanthoma or Pleomorphic Dermal Sarcoma Debulk Specimen from Mohs Surgery: A Requirement for Their Proper Distinction [0.03%]
Mohs手术不规则皮肤肉瘤或非典型纤维黄色瘤扩大切除标本的病理评估：正确区分二者的必要性
Muhammad N Mahmood
Muhammad N Mahmood
Pleomorphic dermal sarcomas can be clinically aggressive, with a higher tendency to cause local recurrence, metastasis, and death. Atypical fibroxanthoma and pleomorphic dermal sarcoma are histopathologically similar, and their distinction ...
Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases [0.03%]
数字乳头状腺癌：一组病例中低危人乳头瘤病毒和BRAF p.V600E突变的检出
Feifan Chen,Priyadharsini Nagarajan,Phyu P Aung
Feifan Chen
Digital papillary adenocarcinoma (DPA) is a rare malignant neoplasm which arises from the sweat glands and has metastatic potential. DPA exhibits a wide range of architectural features and exhibits low-grade to high-grade features, so disti...
The Prognostic Value of Histopathological Features in Early-Stage Mycosis Fungoides: Insights from a Retrospective-Prospective Cohort Study [0.03%]
早期蕈样肉芽肿组织病理特征的预后价值：一项回顾性前瞻性队列研究的启示
Sandra Jerkovic Gulin,Ivana Ilic,Romana Ceovic
Sandra Jerkovic Gulin
Primary cutaneous lymphomas (PCLs), especially mycosis fungoides (MF), pose significant diagnostic and therapeutic challenges. This study aims to correlate initial histological features with the disease course and survival in MF patients. A...
Giant Morpheaform Basal Cell Carcinoma Mimicking Scarring Alopecia: Exception Prone to Neglect [0.03%]
巨大型基底细胞癌模仿瘢痕性斑片状脱发：易被忽视的例外情况
Carlo Francesco Tomasini,Giacomo Fiandrino,Emanuele Mario Favale et al.
Carlo Francesco Tomasini et al.
A 74-year-old woman in good general health presented with a 5-year history of progressive hair loss over several years, interpreted as female androgenetic alopecia (AGA), and was treated with topical 5% Minoxidil without improvement. The pa...
Poikilodermatous Plaque-like Hemangioma: Case Presentation and Literature Review [0.03%]
斑片状皮肤异色症样血管瘤的病例报告及文献回顾
Pablo Díaz-Calvillo,Francisco Vílchez-Márquez,Francisco Manuel Ramos-Pleguezuelos et al.
Pablo Díaz-Calvillo et al.
Poikilodermatous plaque-like hemangioma (PPH) is a recently described clinical and pathological entity, with only 18 cases reported in the literature. Although uncommon, this benign condition presents consistent clinical and histological fi...