Acetone-Ether-Water Mouse Model of Persistent Itch Fully Resolves Without Latent Pruritic or Cross-Modality Priming [0.03%]
丙酮-以太-水小鼠持续瘙痒模型完全解决且无潜伏性瘙痒或跨模式强化现象
Zachary K Ford,Adam J Kirry,Steve Davidson
Zachary K Ford
Hyperalgesic priming is a model of the transition from acute to chronic pain. Whether a similar mechanism exists for "pruritic priming" of itch is unknown. Here, we tested the hypothesis that itchy skin in a commonly used mouse model of dry...
Fadwa Ahmed,Christopher DiMarco
Fadwa Ahmed
Cutaneous silica granulomas are a form of foreign-body granulomatous reactions. They are characterized histopathologically by sarcoidal granulomas in association with silica crystals. Asteroid bodies, a classical histopathological feature o...
Dysplastic Nevi and Superficial Borderline Atypical Melanocytic Lesions: Description of an Algorithmic Clinico-Pathological Classification [0.03%]
发育不良的痣和浅表非典型黑素细胞病变的边缘分类：一种临床病理分类算法描述
Sébastien Menzinger,Rastine Merat,Gürkan Kaya
Sébastien Menzinger
The diagnosis, interpretation, and classification of melanocytic tumors is a very complex topic in the pathology and dermatopathology field that lacks standardization and is still subject to discordance and debate. Here, we review the defin...
Squamomelanocytic Tumor, An Entity Still Shrouded in Mystery: Case Report and Literature Review [0.03%]
仍笼罩在神秘之中的角蛋白-黑色素细胞肿瘤：病例报告及文献复习
Joana Sorino,Mario Della Mura,Anna Colagrande et al.
Joana Sorino et al.
Cutaneous squamomelanocytic tumor (SMT) is a very rare cutaneous malignancy, composed of a dual phenotypic population of both malignant melanocytes and keratinocytes, intimately intermingled together. Herein, we report a new case of a SMT o...
Potential Pitfalls of IgG4 Immunohistochemical Staining on Lesional Tissue in Cutaneous Acantholytic Disorders [0.03%]
皮肤表皮松解性皮肤病病灶组织IgG4免疫组化潜在问题分析
Carla Stephan,Linglei Ma
Carla Stephan
The diagnostic utility of immunohistochemistry on paraffin-embedded sections in bullous disorders is useful when frozen tissue is not available. In pemphigus vulgaris and pemphigus foliaceus, an intercellular lace-like staining pattern of I...
Sylvie Fraitag
Sylvie Fraitag
Paediatric dermatology is still an expanding subspeciality, which is well illustrated by the growing number of books and articles that have been published on this subject in recent years [...].
PRAME Staining of Adnexal Lesions and Common Skin Cancer Types: Biomarker with Potential Diagnostic Utility [0.03%]
PRAME染色在附件肿物和常见皮肤癌中的表达：具有潜在诊断价值的生物标志物
Hisham F Bahmad,John Alexis
Hisham F Bahmad
PRAME (PReferentially expressed Antigen in MElanoma) is a tumor-associated antigen first identified in tumor-reactive T-cell clones derived from a patient with metastatic melanoma. Immunohistochemistry (IHC) for PRAME is useful for diagnost...
A Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance and a Review of Literature [0.03%]
罕见恶性增殖性毛球帽细胞瘤一例并文献复习及分子机制研究
Mokhtar H Abdelhammed,Hanna Siatecka,A Hafeez Diwan et al.
Mokhtar H Abdelhammed et al.
Malignant proliferating trichilemmal tumors (MPTTs), arising from the external root sheath of hair follicles, are exceptionally rare, with limited documentation of their genetic alterations. We present a case of a 64-year-old African Americ...
Digital Papillary Adenocarcinoma Is HPV-42-Associated and BRAFV600E Negative: Perspectives for Diagnostic Practice [0.03%]
数字乳头状腺癌与HPV-42相关且BRAFV600E阴性：诊断实践的展望
Tassilo Dege,Arno Rütten,Matthias Goebeler et al.
Tassilo Dege et al.
Digital papillary adenocarcinoma (DPAC) is a rare, low-grade sweat gland carcinoma primarily found on the hands, fingers, or toes and predominantly affecting males. Distinguishing DPAC from benign sweat gland tumors can be challenging. We p...
Atypical Presentation of Spindle Cell Lipoma in a Young Male with a History of Malignant Melanoma [0.03%]
既往有恶性黑色素瘤病史的年轻男性患者脂肪肉瘤样细胞脂瘤的不典型表现
Ty Theriot,John David Cattar,Lacey Falgout et al.
Ty Theriot et al.
Spindle cell lipoma (SCL) is a benign adipocytic tumor usually found in the subcutis of the posterior neck, upper back, and shoulder, predominantly in middle-aged males. This case report describes an atypical presentation of SCL in a 26-yea...