Immunohistopathological Analysis of Spongiosis Formation in Atopic Dermatitis Compared with Other Skin Diseases [0.03%]
特应性皮炎与其他皮肤病海绵形成免疫组化病理分析
Ryoji Tanei,Yasuko Hasegawa
Ryoji Tanei
Whether the spongiotic reaction caused by the interaction of keratinocytes, T-lymphocytes, inflammatory dendritic epidermal cells (IDECs), and Langerhans cells (LCs) observed in atopic dermatitis (AD) represents a common feature of spongios...
Dermatopathological Challenges in Objectively Characterizing Immunotherapy Response in Mycosis Fungoides [0.03%]
描述免疫检查点抑制剂治疗蕈样肉芽肿客观反应的皮肤病理学挑战
Amy Xiao,Arivarasan Karunamurthy,Oleg Akilov
Amy Xiao
In this review, we explore the complexities of objectively assessing the response to immunotherapy in mycosis fungoides (MF), a prevalent form of cutaneous T-cell lymphoma. The core challenge lies in distinguishing between reactive and mali...
Non-Invasive Diagnostic Techniques in Penile Intraepithelial Neoplasia (PeIN): Insights from Reflectance Confocal Microscopy (RCM), Line-Field Confocal Optical Coherence Tomography (LC-OCT), and Correlation with Histopathological Features [0.03%]
阴茎原位癌非侵入性诊断技术：反射式共聚焦显微镜、线场共焦光学相干断层扫描与组织病理学特征相关性的见解
Caterina Damiani,Cesare Ariasi,Giuseppe La Rosa et al.
Caterina Damiani et al.
Penile intraepithelial neoplasia (PeIN) is a rare but clinically significant condition that can progress to invasive squamous carcinoma. Early diagnosis is crucial but often challenging due to its heterogeneous clinical and dermoscopic pres...
Basal Cell Carcinoma with Sarcomatoid Differentiation-A Rare Type and Its Possible Origin [0.03%]
基底细胞癌肉瘤样分化-一种罕见类型及其可能起源
Nessr Abu Rached,Natalie Orlinski,Eggert Stockfleth et al.
Nessr Abu Rached et al.
Background: We present an interesting case involving a tumour comprising both basal cell tumour cells and sarcomatoid tumour cells. An 86-year-old woman presented with an erythematous lesion on her left cheek. Clinical an...
When Classic Signs Deceive: A Widespread Papulosquamous Eruption in Skin of Colour [0.03%]
当经典体征误导时：肤色人士的广泛皮疹型鳞屑性皮炎
Ji Fung Yong,Claudine Howard-James,Stephen Crowther et al.
Ji Fung Yong et al.
A 29-year-old gentleman of African descent presented to the emergency department with a three month history of a rash affecting the trunk, upper limbs, and thighs. The patient was unsure of any triggers and denied any preceding illness, new...
Influence of Aging and Diabetes on the Mechanical Properties of Mouse Skin [0.03%]
衰老和糖尿病对小鼠皮肤机械性能的影响
Sarah Miny,Gaël Runel,Julien Chlasta et al.
Sarah Miny et al.
Background: Diabetics accumulate Advanced Glycation End products (AGEs) such as Nε-(carboxymethyl)lysine (CML) in their skin, which can provoke changes in the skin's biomechanical properties. The same changes are also ob...
Erythrodermic Psoriasis in the Context of Emerging Triggers: Insights into Dupilumab-Associated and COVID-19-Induced Psoriatic Disease [0.03%]
新兴触发因素下的红皮病型银屑病：杜普利尤单抗相关和新冠肺炎诱导的银屑病的新认识
Aya Fadel,Jayakumar Nithura,Zahraa F Saadoon et al.
Aya Fadel et al.
Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation, impaired epidermal barrier function, and immune dysregulation. The Th17/IL-23 axis plays a central role in its pathogenesis,...
Enric Piqué-Duran,Mikel Azcue-Mayorga,Belinda Roque-Quintana et al.
Enric Piqué-Duran et al.
A 71-year-old Caucasian woman presented with lesions on both elbows. A physical examination revealed arcuate plaques with raised erythematous edges and central clearing. Comedones and cysts were evident on the border of the lesions. The der...
Skin-Colored Papules on the Neck of a Postmenopausal Woman: A Diagnostic Challenge [0.03%]
绝经期女性颈部肤色丘疹的诊断挑战
Jason El Jalkh,Pia Maria Obeid,Dorra Guermazi et al.
Jason El Jalkh et al.
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and ...
Cutaneous Metastases-Histological Particularities of Multifaceted Entities [0.03%]
皮肤转移瘤-多面性实体的组织病理特征
Andreea Cătălina Tinca,Bianca Andreea Lazar,Andreea Raluca Cozac-Szőke et al.
Andreea Cătălina Tinca et al.
Cutaneous metastases from internal organ cancers are diagnosed in approximately 0.2% of skin biopsies. This diagnosis can be the first sign of a previously undiagnosed malignancy with an internal organ origin. We conducted a retrospective s...