ROS1 kinase inhibition reimagined: identifying repurposed drug via virtual screening and molecular dynamics simulations for cancer therapeutics [0.03%]
ROS1激酶抑制剂新设想：通过虚拟筛选和分子动力学模拟鉴定抗癌药再定位候选药物
Mohammed Alrouji,Sabina Yasmin,Fahad A Alhumaydhi et al.
Mohammed Alrouji et al.
Precision medicine has revolutionized modern cancer therapeutic management by targeting specific molecular aberrations responsible for the onset and progression of tumorigenesis. ROS proto-oncogene 1 (ROS1) is a receptor tyrosine kinase (RT...
Editorial: Multi-targeted tyrosine kinase inhibitors in the treatment of cancer and neurodegenerative disorders [0.03%]
特刊主编评述：多靶点酪氨酸激酶抑制剂在癌症和神经退行性疾病治疗中的应用
Belgin Sever,Luciano Saso,Rumiana Tzoneva et al.
Belgin Sever et al.
2D/2D Bi2Se3/SnSe2 heterostructure with rapid NO2 gas detection [0.03%]
具有快速NO2气体检测性能的2D/2D Bi2Se3/SnSe2异质结
Shuangshuang Yi,Cunguang Chen,Meiling Yu et al.
Shuangshuang Yi et al.
Heterostructure engineering is crucial for enhancing gas sensing performance. However, achieving rapid response for room-temperature NO2 sensing through rational heterostructure design remains a challenge. In this study, a Bi2Se3/SnSe2 2D/2...
Efficient In/SSZ-39 catalysts for the selective catalytic reduction of NO with CH4 [0.03%]
高效的In/SSZ-39催化剂用于CH4选择性催化还原NO
Sufeng An,Peng Wang,Kuanling Wang et al.
Sufeng An et al.
The M/SSZ-39 catalysts (M = In, Co, Cu, Fe) with different metal species and metal loadings were synthesized using the wet impregnation method on a small-pore SSZ-39 molecular sieve. X-ray diffraction (XRD), transmission electron microscopy...
Lorenz Heidinger,Isabelle Fix,Thorsten Friedrich et al.
Lorenz Heidinger et al.
The heme synthase AhbD catalyzes the last step of the siroheme-dependent heme biosynthesis pathway, which is operative in archaea and sulfate-reducing bacteria. The AhbD-catalyzed reaction consists of the oxidative decarboxylation of two pr...
Synthesis and characterization of gold(I) thiolate derivatives and bimetallic complexes for HIV inhibition [0.03%]
用于HIV抑制的金(I)硫醇盐衍生物和双金属配合物的合成与表征
Christian K Adokoh,Akwasi Boadu,Isaac Asiamah et al.
Christian K Adokoh et al.
Introduction: The human immunodeficiency virus (HIV) remains a significant global health concern, with a reported high infection rate of 38.4 million cases globally; an estimated 2 million new infections and approximately 700,000 HIV/AIDS-r...
Water determines the intramolecular dynamics of proteins. En example of bovine serum albumin [0.03%]
水决定了蛋白质的分子内动态。以牛血清白蛋白为例
Nikita V Penkov
Nikita V Penkov
In this work, the terahertz time-domain spectroscopy method analyzed solutions of bovine serum albumin (BSA) in two high concentrations (50 and 334 mg/mL) at three pH values (2.5, 6.5, 8.5) and the same solvents without protein, at 25°C. T...
Practical applications of copper-based enzymes: synthesis of sulfonated polyaniline through laccase-catalyzed oxidation [0.03%]
基于铜酶的实际应用：通过漆酶催化氧化合成磺化的聚苯胺
Fabrizia Fabrizi de Biani,Maddalena Corsini,Rebecca Pogni et al.
Fabrizia Fabrizi de Biani et al.
Known for its tunable conductivity and stability, Polyaniline (PANI) is a valuable polymer for electronics and sensing devices. Challenges in solubility have been addressed by creating sulfonated PANI (SPANI), enhancing its practical use. S...
Design, synthesis, and bioevaluation of diarylpyrimidine derivatives as novel microtubule destabilizers [0.03%]
新型微管破坏剂二芳基嘧啶衍生物的设计、合成及生物评价
Yutao Xiu,Yujing Zhang,Shanbo Yang et al.
Yutao Xiu et al.
In this work, a series of new diarylpyrimidine derivatives as microtubule destabilizers were designed, synthesized, and evaluated for anticancer activities. Based on restriction configuration strategy, we introduced the pyrimidine moiety co...
Novel metabolite madeirone and neomarinone extracted from Streptomyces aculeoletus as marine antibiofilm and antifouling agents [0.03%]
从链霉菌中提取的新代谢产物马德拉酮和海洋抗菌膜和防污剂诺玛林酮
Julian L Wissner,Joana R Almeida,Inês R Grilo et al.
Julian L Wissner et al.
Introduction: Biofouling poses a significant economic threat to various marine industries, leading to financial losses that can reach billions of euros annually. This study highlights the urgent need for effective alternatives to traditiona...