Synthesis, structure-activity relationships, and SARS-CoV-2 antiviral activity of 3,5-disubstituted isothiazolo[4,3- b]pyridines as PIKfyve inhibitors [0.03%]
3,5-二取代异噻唑并[4,3-b]吡啶类PIKfyve抑制剂的合成、构效关系及其抗SARS-CoV-2活性研究
Ling-Jie Gao,Demian Kalebic,Chieh Wen Lo et al.
Ling-Jie Gao et al.
Introduction: 3-Alkynyl-6-aryl-isothiazolo[4,3-b]pyridines have previously been shown to be potent inhibitors of the lipid kinase FYVE finger-containing phosphoinositide kinase (PIKfyve), displaying broad-spectrum antivir...
An In silico analysis on the phosphorylation dependent structural and thermal stability of thermophilic proteins [0.03%]
蛋白质热激依赖性磷酸化调控的分子机制研究进展
Sermarajan Arunachalam,Ramachandran Gnanasekaran
Sermarajan Arunachalam
In the present study the effect of phosphorylation on the structural stability and energy transfer in two structurally homologous thermophilic proteins, 1QMP and 1DZ3 were investigated. In 1QMP one of the residues (Asp55) phosphorylated whi...
Cesar Augusto Roque-Borda,Anamika Sharma,Fernando Rogério Pavan et al.
Cesar Augusto Roque-Borda et al.
Peptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often interpreted uncritical...
Phosphorus recovery from high-COD and strongly acidic wastewater by vivianite crystallization: feasibility and optimization of operating conditions [0.03%]
黄铁矿酸性高化学需氧量废水中磷通过磷灰石结晶进行回收的可行性及操作条件优化研究
Kai Cui,Guangyu Xu,Fei Ma et al.
Kai Cui et al.
Acidified oil wastewater contains high concentrations of phosphorus and organic pollutants, which not only pose environmental risks but also contain recoverable phosphorus resources. However, its complex matrix (high COD and acidic environm...
Correction: Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines [0.03%]
关于功能化己氢奎宁类化合物的化学和治疗潜力的新见解纠正通知
Gbolahan O Oduselu,Rhoda O Olatuyi,Omowunmi O Fatoki et al.
Gbolahan O Oduselu et al.
[This corrects the article DOI: 10.3389/fchem.2026.1769586.]. Keywords: antiprotozoal agents; drug discovery...
Published Erratum
Frontiers in chemistry. 2026 May 1:14:1852717. DOI:10.3389/fchem.2026.1852717 2026
Editorial: New trends in green chemistry: sustainable and alternative strategies for the extraction of high-value compounds from agri-food matrices and residues [0.03%]
评述：绿色化学新趋势：从农业食品基质和残留物中提取高价值化合物的可持续和替代策略
Francesca Annunziata,Gigliola Borgonovo,Patricia Rijo et al.
Francesca Annunziata et al.
Underwater drag reduction via self-healing and robust air plastrons stabilized by candle soot-based coatings [0.03%]
基于蜡烛炭黑的涂层稳定自修复和鲁棒气体保护膜实现水下减阻
Muhammad Imran Jamil,Arshia Komal,Mehboob Hassan et al.
Muhammad Imran Jamil et al.
In marine environments, the increased drag force on vehicles impedes their speed underwater, leading to high energy consumption and reduced vehicle efficiency. Superhydrophobic coatings have gained remarkable attention regarding drag reduct...
Diol-enhanced natural deep eutectic solvents for efficient poplar pretreatment [0.03%]
用于高效杨木预处理的二醇增强型天然深吴溶剂
Chaehwi Yoon,Jiae Ryu,Soyeon Jeong et al.
Chaehwi Yoon et al.
Natural deep eutectic solvents (NDESs) are promising biomass pretreatment media, but their industrial application is often hindered by high viscosity. To address this limitation, diol-enhanced ternary DESs (TDESs) were prepared by incorpora...
Discovery of novel quinazoline-sulfonamide derivatives with promising antidiabetic activity [0.03%]
一类具有潜在降糖活性的新型喹唑啉-磺胺衍生物的发现
Mohamed F Zayed,Yosra Muhammad,Aymen A Alqurain et al.
Mohamed F Zayed et al.
Introduction: Five new quinazoline-sulfonamide hybrids 4a (MZ-13), 4b (MZ-20), 4c (MZ-25), 4d (MZ-26), and 6a (MZ-29) were designed, synthesized, and investigated for their in vitro and in vivo antidiabetic activities. ...
Eco-friendly synthesis of an antimicrobial polymer (1,4-bis(methacryloyl)piperazine) via maghnite catalysis: in vitro activity and in silico drug-likeness [0.03%]
磁铁矿催化合成抗菌高分子（1,4-双（甲基丙烯酰氧基）哌嗪）的绿色方法及体外活性与药理作用预测研究
Samira Derkaoui,Farouk Boudou,Ahcene Keziz et al.
Samira Derkaoui et al.
Background: Poly (1,4-bis(methacryloyl)piperazine) (poly (NBMP)) is a piperazine-based polymer with potential biomedical applications. Green clay catalysts, maghnite-H+ and maghnite-Na+; offer an eco-friendly approach for...