Reduction of Hepatitis B Surface Antigen May Be More Significant in PEGylated Interferon-Alpha Therapy Combined with Nucleotide Analogues than Combined with Nucleoside Analogues in Chronic Hepatitis B Patients: A Propensity Score Matching Study [0.03%]
聚乙二醇化干扰素α联合核苷酸类似物较联合核苷类似物治疗慢性乙肝患者可能更显著降低乙型肝炎表面抗原：倾向性评分匹配研究
Yiran Xie,Haoxiang Zhu,Yifei Guo et al.
Yiran Xie et al.
Background: Nucleotide analogues (NTs) monotherapy may have a more significant effect on reducing hepatitis B surface antigen (HBsAg) than nucleoside analogues (NSs) due to their immunomodulatory function. However, this s...
The Characteristics of Diverticular Disease in Caribbean Population: A Control Group Study [0.03%]
加勒比人群憩室病的特征：一项对照组研究
Moana Gelu-Simeon,Matthieu Schnee,Marie-Josée Lafrance et al.
Moana Gelu-Simeon et al.
Background: Diverticulosis is not well characterized in the Caribbeans. Our aim was to compare the anatomical presentation of colonic diverticulosis in African Caribbeans (group AC) versus Europeans (group E) and severity...
Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy [0.03%]
肝病与COVID-19：从病理生理到治疗策略
Parisa Shiri Aghbash,Hamed Ebrahimzadeh Leylabadlo,Hamidreza Fathi et al.
Parisa Shiri Aghbash et al.
Following the SARS-CoV-2 outbreak and the subsequent development of the COVID-19 pandemic, organs such as the lungs, kidneys, liver, heart, and brain have been identified as priority organs. Liver diseases are considered a risk factor for h...
Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis? [0.03%]
神经类固醇GABA-A受体的激活：原发性胆汁性胆管炎症状治疗的新靶点？
Aaron Wetten,Laura Ogle,George Mells et al.
Aaron Wetten et al.
Background and aims: A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment. Allo...
Comprehensive Analysis of N6-Methyladenosine (m6A) RNA Methylation Regulators and Tumour Microenvironment Cell Infiltration Involving Prognosis and Immunotherapy in Gastroesophageal Adenocarcinomas [0.03%]
胃食管腺癌中影响预后和免疫治疗的N6-甲基腺苷(m6A)RNA甲基化调节因子及肿瘤微环境细胞浸润的综合分析
Duanrui Liu,Mingjie Yuan,Zongming Wang et al.
Duanrui Liu et al.
Objective: Gastroesophageal adenocarcinoma (GEA) is a high deadly and heterogeneous cancer. RNA N6-methyladenosine (m6A) modification plays a non-negligible role in shaping individual tumour microenvironment (TME) charact...
Virological Changes of Chronic Hepatitis B Patients with Minimally Elevated Levels of Alanine Aminotransferase: A Meta-Analysis and Systematic Review [0.03%]
丙氨酸氨基转移酶轻度升高慢性乙型肝炎患者的病毒学改变：一项荟萃分析和系统回顾
Xiyao Chen,Xingrong Zheng,Hewei Wu et al.
Xiyao Chen et al.
Background: Chronic hepatitis B (CHB) patients with normal or minimally increased levels of alanine aminotransferase (ALT) are still at the risk of hepatocellular carcinoma, cirrhotic events, and mortality. However, there...
Immunohistochemical Differentiation between Western and East Asian Types of CagA-Positive Helicobacter pylori in Gastric Biopsy Samples [0.03%]
胃活检样本中CagA阳性西方型和东亚型幽门螺杆菌的免疫组化鉴别
Daisuke Kobayashi,Keisuke Uchida,Asuka Furukawa et al.
Daisuke Kobayashi et al.
Background: Cag A-positive Helicobacter pylori isolated from human gastric mucosa is categorized as a Western or East Asian allele-type based on whether the cagA gene encodes an EPIYA-C or EPIYA-D motif. We aimed to diffe...
Construction of a Prognostic Model Based on Cuproptosis-Related lncRNA Signatures in Pancreatic Cancer [0.03%]
基于铜死亡相关lncRNA特征的胰腺癌预后模型的构建
Wenkai Jiang,Yan Du,Wenlong Zhang et al.
Wenkai Jiang et al.
Aim: The aim of this study is to identify cuproptosis-related lncRNAs and construct a prognostic model for pancreatic cancer patients for clinical use. Me...
The Role of Combining Probiotics in Preventing and Controlling Inflammation: A Focus on the Anti-Inflammatory and Immunomodulatory Effects of Probiotics in an In Vitro Model of IBD [0.03%]
益生菌结合使用在预防和控制炎症中的作用：重点探讨益生菌在体外IBD模型中抗炎和免疫调节效应
Shadi Aghamohammad,Amin Sepehr,Seyedeh Tina Miri et al.
Shadi Aghamohammad et al.
Objective: IBD is an inflammatory disease with abnormalities such as dysbiosis and abnormal immune system activity. Probiotics, as live beneficial microorganisms, play a role in maintaining health through various mechanis...
Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease [0.03%]
非酒精性脂肪肝疾病的调控网络、管理方法及新兴治疗方法
Bing Yang,Xi Yang,Xumei Tan et al.
Bing Yang et al.
The pathogenesis of NAFLD is complex and diverse, involving multiple signaling pathways and cytokines from various organs. Hepatokines, stellakines, adipokines, and myokines secreted by hepatocytes, hepatic stellate cells, adipose tissue, a...