Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis [0.03%]
Activin和肝细胞生长因子的顺序治疗诱导FOXM1以促进结直肠癌肝转移
Hong Peng,Ting Ye,Lei Deng et al.
Hong Peng et al.
Background: Cancer stem cells (CSCs) are involved in liver metastasis in colorectal cancer (CRC). Activin and hepatocyte growth factor (HGF) are important regulators of stem cell properties. This study was performed to ex...
Overexpression of microRNA-211 in Functional Dyspepsia via Downregulation of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) by Increasing Phosphorylation of p38 MAPK Pathway [0.03%]
通过增加p38MAPK通路的磷酸化下调胶质细胞系源性神经营养因子(GDNF)来在功能性消化不良中过表达microRNA-211
Jue Wang,Sai Gu,Bo Qin
Jue Wang
Background: Overexpression of miRNA-211 suppresses the differentiation of bone marrow stem cells into intestinal ganglion cells via downregulation of GDNF, a regulator of intestine barrier function. The study aimed to inv...
The Relationship and Changes of Liver Blood Supply, Portal Pressure Gradient, and Liver Volume following TIPS in Cirrhosis [0.03%]
肝硬化患者经TIPS治疗后的肝血供、门静脉压力梯度和肝脏体积的关系及变化
Jinghong He,Jinyu Li,Changxing Fang et al.
Jinghong He et al.
Aim: Transjugular intrahepatic portosystemic shunt (TIPS) alters the liver blood supply and reduces portal pressure. This study was to investigate the changes and associations of the hepatic blood flow, liver volume, and ...
Reduction of Hepatitis B Surface Antigen May Be More Significant in PEGylated Interferon-Alpha Therapy Combined with Nucleotide Analogues than Combined with Nucleoside Analogues in Chronic Hepatitis B Patients: A Propensity Score Matching Study [0.03%]
聚乙二醇化干扰素α联合核苷酸类似物较联合核苷类似物治疗慢性乙肝患者可能更显著降低乙型肝炎表面抗原：倾向性评分匹配研究
Yiran Xie,Haoxiang Zhu,Yifei Guo et al.
Yiran Xie et al.
Background: Nucleotide analogues (NTs) monotherapy may have a more significant effect on reducing hepatitis B surface antigen (HBsAg) than nucleoside analogues (NSs) due to their immunomodulatory function. However, this s...
The Characteristics of Diverticular Disease in Caribbean Population: A Control Group Study [0.03%]
加勒比人群憩室病的特征：一项对照组研究
Moana Gelu-Simeon,Matthieu Schnee,Marie-Josée Lafrance et al.
Moana Gelu-Simeon et al.
Background: Diverticulosis is not well characterized in the Caribbeans. Our aim was to compare the anatomical presentation of colonic diverticulosis in African Caribbeans (group AC) versus Europeans (group E) and severity...
Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy [0.03%]
肝病与COVID-19：从病理生理到治疗策略
Parisa Shiri Aghbash,Hamed Ebrahimzadeh Leylabadlo,Hamidreza Fathi et al.
Parisa Shiri Aghbash et al.
Following the SARS-CoV-2 outbreak and the subsequent development of the COVID-19 pandemic, organs such as the lungs, kidneys, liver, heart, and brain have been identified as priority organs. Liver diseases are considered a risk factor for h...
Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis? [0.03%]
神经类固醇GABA-A受体的激活：原发性胆汁性胆管炎症状治疗的新靶点？
Aaron Wetten,Laura Ogle,George Mells et al.
Aaron Wetten et al.
Background and aims: A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment. Allo...
Comprehensive Analysis of N6-Methyladenosine (m6A) RNA Methylation Regulators and Tumour Microenvironment Cell Infiltration Involving Prognosis and Immunotherapy in Gastroesophageal Adenocarcinomas [0.03%]
胃食管腺癌中影响预后和免疫治疗的N6-甲基腺苷(m6A)RNA甲基化调节因子及肿瘤微环境细胞浸润的综合分析
Duanrui Liu,Mingjie Yuan,Zongming Wang et al.
Duanrui Liu et al.
Objective: Gastroesophageal adenocarcinoma (GEA) is a high deadly and heterogeneous cancer. RNA N6-methyladenosine (m6A) modification plays a non-negligible role in shaping individual tumour microenvironment (TME) charact...
Virological Changes of Chronic Hepatitis B Patients with Minimally Elevated Levels of Alanine Aminotransferase: A Meta-Analysis and Systematic Review [0.03%]
丙氨酸氨基转移酶轻度升高慢性乙型肝炎患者的病毒学改变：一项荟萃分析和系统回顾
Xiyao Chen,Xingrong Zheng,Hewei Wu et al.
Xiyao Chen et al.
Background: Chronic hepatitis B (CHB) patients with normal or minimally increased levels of alanine aminotransferase (ALT) are still at the risk of hepatocellular carcinoma, cirrhotic events, and mortality. However, there...
Immunohistochemical Differentiation between Western and East Asian Types of CagA-Positive Helicobacter pylori in Gastric Biopsy Samples [0.03%]
胃活检样本中CagA阳性西方型和东亚型幽门螺杆菌的免疫组化鉴别
Daisuke Kobayashi,Keisuke Uchida,Asuka Furukawa et al.
Daisuke Kobayashi et al.
Background: Cag A-positive Helicobacter pylori isolated from human gastric mucosa is categorized as a Western or East Asian allele-type based on whether the cagA gene encodes an EPIYA-C or EPIYA-D motif. We aimed to diffe...