GPR39 Suppresses Ferroptosis via the Nrf2/SLC7A11 Axis and Reduces the Sensitivity of Colorectal Cancer to Anti-PD-1 Immunotherapy [0.03%]
GPR39通过Nrf2/SLC7A11轴抑制铁死亡并降低结直肠癌对抗PD-1免疫治疗的敏感性
Cong Zhou,Xiaoling Fang,Jiaying Lin et al.
Cong Zhou et al.
Background: PD-1 blockade has yet to achieve broad clinical success in colorectal cancer (CRC), with microsatellite-stable tumors proving especially resistant. At the same time, ferroptosis has emerged as a mechanistic li...
Beyond the INR: Thromboelastography Carries Prognostic Information in Critically Ill Patients With Cirrhosis [0.03%]
国际正常化比率之外：血栓弹力图对肝硬化重症患者的预后信息价值
Franklyn K Wallace,Puru Rattan,Ryan J Lennon et al.
Franklyn K Wallace et al.
Background: In patients with cirrhosis, prolonged international normalized ratio (INR) is primarily driven by liver synthetic dysfunction. Thromboelastography more accurately reflects coagulability and can also predict sh...
Investigating the Link Between Smoking and Fatty Liver via Ultrasound Elastography: A Cross-Sectional Analysis Study [0.03%]
基于超声弹性图的吸烟与脂肪肝关系研究：横断面分析研究
Yue Feng,Zhengqing Mu,Changsong Xu et al.
Yue Feng et al.
Objective: To investigate the link between smoking and fatty liver, particularly the influence of different smoking patterns on its prevalence, aiming to provide insights for public health policies. ...
Low-Volume Plasma Exchange Combined With a Double Plasma Molecular Adsorption System is Superior to Standard-Volume Plasma Exchange in improving the MELD Score and Reducing Plasma Consumption in Adult Patients With Acute Liver Failure: A Multicenter Retrospective Cohort Study From Heilongjiang Province [0.03%]
低容积血浆置换联合双重血浆分子吸附系统治疗急性肝衰竭较常规容量血浆置换更有效改善MELD评分并减少血浆消耗：一项黑龙江多中心回顾性队列研究
Yang Liu,Jia-Le Deng,Shu-Xiao Qiu et al.
Yang Liu et al.
Objective: This research aimed to investigate the disparities in improving the model for end-stage liver disease (MELD) score and plasma volume consumption between standard-volume plasma exchange (SVPE) and low-volume pla...
Epidemiological Transition of Nonalcoholic Fatty Liver Disease and Cirrhosis in Asia: Three Decades of Spatiotemporal Dynamics, Health Inequality, and Future Burden [0.03%]
亚洲非酒精性脂肪肝和肝硬化的流行病学过渡：三十年的时空动态、健康不平等及未来疾病负担
Xiaoheng Liu,Chen Zhou
Xiaoheng Liu
Objective: To analyze spatiotemporal distribution, health inequalities, and future trends of nonalcoholic fatty liver disease (NAFLD) burden in Asia from 1990 to 2023. ...
Rifaximin Plus Probiotics Reshape Gut Microbiota, Serum Propionate, and Mucosal Immunity in Cirrhosis-Related Hepatic Encephalopathy Microbiota-Immune Remodeling in HE [0.03%]
利福昔敏联合益生菌可调节肝性脑病患者的肠道微生物组、粪便和血清短链脂肪酸以及肠黏膜免疫功能
Yiping Wang,Hui Zhu,Shujun Wang et al.
Yiping Wang et al.
Background: Hepatic encephalopathy (HE) remains a major cause of hospitalization and readmission in cirrhosis and is closely linked to hyperammonemia, microbial dysbiosis, impaired short-chain fatty acid (SCFA) output, ba...
Randomized Controlled Trial
Canadian journal of gastroenterology & hepatology. 2026;2026(1):e2389961. DOI:10.1155/cjgh/2389961 2026
Integrative Transcriptomics Across Etiologies Reveals Common and Disease-Specific Fibrogenic Signatures in Liver Fibrosis [0.03%]
整合转录组学揭示肝纤维化中共同的和疾病特异性的致痕分子标志物
Wenyan Yang,Long Li,Yamei Ye et al.
Wenyan Yang et al.
Background: Chronic liver diseases caused by metabolic, viral, and mixed etiologies frequently converge on fibrosis and cirrhosis; however, the extent to which fibrogenic mechanisms are shared across etiologies versus dis...
FUT2-Mediated Fucosylation of OLFM4 Promotes Colon Cancer Cell Differentiation [0.03%]
FUT2介导的OLFM4岩藻糖基化促进结肠癌细胞分化
Caihan Duan,Keyi Zhang,Lingzhi Hou et al.
Caihan Duan et al.
Background: Fucosyltransferase 2 (FUT2) deficiency exacerbates inflammation, a known risk factor for colon cancer. However, the precise role and underlying mechanism of FUT2 in regulating colon cancer cell differentiation...
Development and Validation of the Steatotic Liver Disease Lab Data Index: A Refined Diagnostic Tool [0.03%]
用于诊断肝脏脂肪变的实验室指标(SLD-LDI)的建立和验证
Weiting Liaw,Pei-Chien Tsai,Ming-Lung Yu et al.
Weiting Liaw et al.
Aims: Steatotic liver disease (SLD) is highly prevalent, yet large-scale identification remains challenging because imaging is not always available and existing noninvasive indices perform heterogeneously across subgroups...
Independent Prognosis Prediction of Hepatocellular Carcinoma Using MicroRNA-Based Single and Combined Biomarkers [0.03%]
基于微小核糖核酸的单一和联合生物标志物预测肝细胞癌独立预后
Long-Bin Jeng,Wen-Ling Chan,Chiao-Fang Teng
Long-Bin Jeng
Although there are various treatment modalities available for hepatocellular carcinoma (HCC), HCC is still among the most common causes of cancer-related death globally. Identifying independent biomarkers of poor prognosis in HCC patients r...