Recent advances in in vivo genotoxicity testing: prediction of carcinogenic potential using comet and micronucleus assay in animal models [0.03%]
活体基因毒性检测的最新进展：使用动物模型中的彗星和微核测定法预测致癌性
Seung Hun Kang,Jee Young Kwon,Jong Kwon Lee et al.
Seung Hun Kang et al.
Genotoxic events have been known as crucial step in the initiation of cancer. To assess the risk of cancer, genotoxicity assays, including comet, micronucleus (MN), chromosomal aberration, bacterial reverse, and sister chromatid exchange as...
Oxidative DNA Damage Response in Helicobacter pylori-Infected Mongolian Gerbils [0.03%]
氧化性DNA损伤修复在幽门螺杆菌感染的蒙古地鼠模型中的作用研究
Minkyung Bae,Joo Weon Lim,Hyeyoung Kim
Minkyung Bae
Helicobacter pylori (H. pylori) induced DNA damage which may be related to gastric cancer development. The DNA damage response coordinates DNA repair, cell-cycle transition, and apoptosis through activation of DNA damage response molecules....
Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells [0.03%]
檞皮素通过增加HCT116结肠癌细胞内ROS诱导凋亡及调节Sescrinen 2-AMPK-mTOR信号通路的作用研究
Guen Tae Kim,Se Hee Lee,Young Min Kim
Guen Tae Kim
Background: The suppression of abnormal cell proliferation is therapeutic strategies for the treatment of cancer. In this study, we investigated the regulatory mechanism of quercetin-induced apoptosis through regulation o...
Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells [0.03%]
kaempferol诱导HT-29人类结肠癌细胞周期停止
Han Jin Cho,Jung Han Yoon Park
Han Jin Cho
Background: A greater intake of vegetables and fruits has been linked to a reduced incidence of colon cancer. Flavonoids are polyphenolic compounds which are broadly distributed in fruits and vegetables and display a rema...
Morin Induces Heme Oxygenase-1 via ERK-Nrf2 Signaling Pathway [0.03%]
MOR的抗抑郁作用与ERK-Nrf2-HO-1信号转导途径有关
Ji Young Park,Kyoung Ah Kang,Ki Cheon Kim et al.
Ji Young Park et al.
Background: Oxidative stress damages to cells or tissues, however, cellular defense systems including heme oxygenase-1 (HO-1) protects them against oxidative stress. Flavonoid compounds can activate cellular defense mecha...
Global Inactivation of the Pla2g6 Gene in Mice Does Not Cause Dyslipidemia under Chow or High-fat Diet Conditions [0.03%]
在小鼠中全球失活Pla2g6基因不会导致普通或高脂饮食条件下的血脂异常
Li Zhang,Shumei Zhong,Ying Li et al.
Li Zhang et al.
Background: Genome-wide association studies suggest that plasma triacylglyceride (TAG) in humans was associated with variation in the PLA2G6 locus, a gene that encodes calcium-independent phospholipase A2 (iPLA2 β). The ...
Epigenetic therapies as a promising strategy for overcoming chemoresistance in epithelial ovarian cancer [0.03%]
表观遗传疗法在克服上皮性卵巢癌化疗耐药中的应用前景
Dong Hoon Suh,Mi-Kyung Kim,Hee Seung Kim et al.
Dong Hoon Suh et al.
Over the past decades, prognosis of advanced stage epithelial ovarian cancer remains very poor, despite the development of new chemotherapeutic drugs, as well as molecular targeted agents. Late presentation and frequent chemoresistance acco...
Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells [0.03%]
癌基因和肿瘤抑制因子调节癌症细胞中的谷氨酰胺代谢
Min Hyun Kim,Hyeyoung Kim
Min Hyun Kim
Several hallmarks of cancer cells are their display of metabolic changes and enhanced proliferation. Highly proliferating cells utilize glutamine as a source of nitrogen, and therefore, one of the commonly seen metabolic changes is increase...
Discovery of prognostic factors for diagnosis and treatment of epithelial-derived ovarian cancer from laying hens [0.03%]
来自产蛋鸡的上皮源性卵巢癌诊断和治疗的预后因素的发现
Whasun Lim,Gwonhwa Song
Whasun Lim
Ovarian cancer is a lethal gynecological cancer causing cancer-related deaths in women worldwide. It is difficult to diagnosis at an early stage when more than 90% patients can be cured because of lack of specific symptoms and early detecti...
Omega-3 polyunsaturated Fatty acids as potential chemopreventive agent for gastrointestinal cancer [0.03%]
ω-3多不饱和脂肪酸作为消化道肿瘤的化学预防剂的潜力研究进展
Jong-Min Park,Sung-Hun Kwon,Young-Min Han et al.
Jong-Min Park et al.
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly eicosapentanoic acid (EPA) and docosahexanoic acid (DHA), has been acknowledged as essential very long-chain fatty acids contributing to either achieving optimal health or protec...