Astaxanthin Inhibits Helicobacter pylori-induced Inflammatory and Oncogenic Responses in Gastric Mucosal Tissues of Mice [0.03%]
虾青素通过抑制小鼠胃黏膜组织的炎症和致癌反应发挥抗幽门螺旋杆菌作用
Hwana Han,Joo Weon Lim,Hyeyoung Kim
Hwana Han
Helicobacter pylori is recognized as a risk factor for gastric carcinogenesis. The chronic exposure of gastric epithelium to H. pylori induces a prolonged inflammatory state that may progress to gastric cancer. Astaxanthin, a pinkish antiox...
Interaction between Peptidyl-prolyl Cis- trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance [0.03%]
脯氨酰顺反异构酶NIMA相互作用1与GTP-H-Ras之间的相互作用及其对人乳腺上皮细胞侵袭性及耐药性的意义
Soma Saeidi,Sihyung Joo,Su-Jung Kim et al.
Soma Saeidi et al.
Aberrant activation of Ras has been implicated in aggressiveness of breast cancer. Among Ras isoforms (H-, K-, and N-), H-Ras has been known to be primarily responsible for invasion and metastasis of breast cancer cells. Phosphorylation of ...
Colon Cancer Risk of a Westernized Diet Is Reduced in Mice by Feeding Cruciferous or Apiaceous Vegetables at a Lower Dose of Carcinogen but Not a Higher Dose [0.03%]
十字花科和伞形科蔬菜以低剂量致癌物而非高剂量给药可降低西方饮食小鼠的结肠癌风险
Sangyub Kim,Breann E Abernathy,Sabrina P Trudo et al.
Sangyub Kim et al.
Western-style diets (WD) are associated with greater risk of colon cancer. Exposure to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a food-borne carcinogen, is linked to increased colon cancer risk. In contrast, intake of apiaceo...
Recent Advances in the Development of TGF-β Signaling Inhibitors for Anticancer Therapy [0.03%]
抗癌治疗中TGF-β信号抑制剂研发的最新进展
Ho-Jae Lee
Ho-Jae Lee
TGF-β is a multifunctional cytokine that plays an important role in both physiologic and pathologic processes, including cancer. Importantly, TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor or a tumor promoter, depend...
Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway [0.03%]
SR-related高迁移率族蛋白17通过拮抗Wnt信号途径发挥肿瘤抑制作用
Maha Anani,Ikuo Nobuhisa,Tetsuya Taga
Maha Anani
A transcription factor Sry-related high mobility group box (Sox) 17 is involved in developmental processes including spermatogenesis, cardiovascular system, endoderm formation, and so on. In this article, we firstly review the studies on th...
Targeting Epigenetic 'Readers' with Natural Compounds for Cancer Interception [0.03%]
利用天然化合物靶向表观遗传“阅读器”以拦截癌症
Elisabetta Damiani,Munevver N Duran,Nivedhitha Mohan et al.
Elisabetta Damiani et al.
Natural compounds from diverse sources, including botanicals and commonly consumed foods and beverages, exert beneficial health effects via mechanisms that impact the epigenome and gene expression during disease pathogenesis. By targeting t...
Patient-centered Weight Tracking as an Early Cancer Detection Strategy [0.03%]
以患者为中心的体重监测作为早期癌症检测策略
Jonathan J Hue,Sarah C Markt,Goutham Rao et al.
Jonathan J Hue et al.
Early detection is a valued strategy to decrease cancer mortality rates; however, new strategies are needed. Unintentional weight loss (UWL) is experienced by patients across the cancer spectrum, but often goes unnoticed. Patient-centered w...
Junghyun Yoon,Boyoung Park
Junghyun Yoon
In this study, we compared health behaviors, including current smoking, drinking, and physical inactivity, in thyroid cancer survivors and non-cancer controls and investigated the factors associated with unhealthy behaviors among survivors....
Gallstones, Cholecystectomy and the Risk of Hepatobiliary and Pancreatic Cancer: A Nationwide Population-based Cohort Study in Korea [0.03%]
胆石症、胆囊切除术与肝胆胰系癌症的风险：韩国全国性人口基础队列研究
Dan Huang,Joonki Lee,Nan Song et al.
Dan Huang et al.
Several epidemiological studies suggest a potential association between gallstones or cholecystectomy and hepatobiliary and pancreatic cancers (HBPCs). The aim of this study was to evaluate the risk of HBPCs in patients with gallstones or p...
15-Deoxy-Δ12,14-prostaglandin J2 Induces Epithelial-to-mesenchymal Transition in Human Breast Cancer Cells and Promotes Fibroblast Activation [0.03%]
15-脱氧-Δ12,14-前列腺素J2诱导人乳腺癌细胞的上皮间充质转化并促进成纤维细胞活化
Jeehye Choi,Jin-Young Suh,Do-Hee Kim et al.
Jeehye Choi et al.
In inflammation-associated carcinogenesis, COX-2 is markedly overexpressed, resulting in accumulation of various prostaglandins. 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is one of the terminal products of COX-2-catalyzed arachidonic aci...