Dioscin Decreases Breast Cancer Stem-like Cell Proliferation via Cell Cycle Arrest by Modulating p38 Mitogen-activated Protein Kinase and AKT/mTOR Signaling Pathways [0.03%]
异蔬雄酮通过调节p38丝裂原活化蛋白激酶和AKT/mTOR信号通路引起细胞周期阻滞从而降低乳腺癌干细胞样细胞的增殖能力
Won Ock Chae,Gi Dae Kim
Won Ock Chae
Dioscin (DS), a steroidal saponin, has been shown to have anti-cancer activity by exerting antioxidant effects and inducing apoptosis. However, the anti-cancer activity of DS in breast cancer-derived stem cells is still controversial. The p...
F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2 [0.03%]
F-box蛋白βTrCP1是细胞外信号调节激酶2的底物
Cheol-Jung Lee,Ga-Eun Lee,Hyun-Jung An et al.
Cheol-Jung Lee et al.
F-box proteins, consisting of 69 members which are organized into the three subclasses FBXW, FBXL, and FBXO, are the substrate specific recognition subunits of the SKP1-Cullin 1-F-box protein E3 ligase complex. Although βTrCP 1 and 2, memb...
miRNA-200b Signature in the Prevention of Skin Cancer Stem Cells by Polyphenol-enriched Blueberry Preparation [0.03%]
富含多酚的越橘制剂通过miRNA-200b标志物预防皮肤癌干细胞的能力研究
Nawal Alsadi,Jean-François Mallet,Chantal Matar
Nawal Alsadi
Exposure of the skin to solar UV radiation leads to inflammation, DNA damage, and dysregulation of cellular signaling pathways, which may cause skin cancer. Photochemoprevention with natural products is an effective strategy for the control...
Genomic Approach to the Assessment of Adverse Effects of Particulate Matters on Skin Cancer and Other Disorders and Underlying Molecular Mechanisms [0.03%]
基因组方法评估颗粒物对皮肤癌和其他疾病的不良影响及其潜在分子机制
Nam Gook Kee,Hyun Soo Kim,Hyunjung Choi et al.
Nam Gook Kee et al.
Air pollutants are in the spotlight because the human body can easily be exposed to them. Among air pollutants, the particulate matter (PM) represents one of the most serious toxicants that can enter the human body through various exposure ...
Cryptotanshinone Prevents the Binding of S6K1 to mTOR/Raptor Leading to the Suppression of mTORC1-S6K1 Signaling Activity and Neoplastic Cell Transformation [0.03%]
Cryptotanshinone通过阻止S6K1与mTOR/Raptor结合抑制mTORC1-S6K1信号通路及肿瘤细胞转化
Nam Ho Jeoung,Ji Yun Jeong,Bong Seok Kang
Nam Ho Jeoung
Cryptotanshinone is known for its inhibitory activity against tumorigenesis in various human cancer cells. However, exact mechanisms underlying the anticancer effects of cryptotanshinone are not fully elucidated. Here, we propose a plausibl...
Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells [0.03%]
结肠癌细胞中TFF1通过抑制TGF-β信号通路抑制上皮间质转化作用
Da-Young Lee,Moon-Young Song,Eun-Hee Kim
Da-Young Lee
Gastric cancer is a malignancy with high incidence and mortality worldwide. In gastric cancer, epithelial-mesenchymal transition (EMT) and metastasis further increase the mortality rate. Trefoil factor 1 (TFF1) has been reported as a protec...
Mechanistic Targets of Diallyl Trisulfide in Human Breast Cancer Cells Identified by RNA-seq Analysis [0.03%]
RNA测序分析鉴定出大蒜素对人乳腺癌细胞的靶点
Eun-Ryeong Hahm,Su-Hyeong Kim,Sivapar V Mathan et al.
Eun-Ryeong Hahm et al.
Diallyl trisulfide (DATS), a metabolic by-product of processed garlic, is highly effective in inhibiting growth of human breast cancer cells in vitro and in vivo, but the underlying mechanisms are still not fully understood. In this study, ...
Protective Effects of Silibinin on Helicobacter pylori-induced Gastritis: NF-κB and STAT3 as Potential Targets [0.03%]
白飞灵对治疗幽门螺旋杆菌所致胃炎的保护作用及NF-κB和STAT3的作用机制研究中文标题：白飞灵对幽门螺旋杆菌致胃炎的保护作用及机制研究:NF-κB和STAT3可能是潜在靶点
Kyunghwa Cho,Hee Geum Lee,Juan-Yu Piao et al.
Kyunghwa Cho et al.
More than half of the world's populations are considered to be infected by Helicobacter pylori. It causes a chronic inflammation of the stomach, which is implicated in the pathogenesis of gastric ulcer and cancer. Silibinin, a polyphenolic ...
Income and Education Inequalities in Brain and Central Nervous System Cancer Incidence in Canada: Trends over Two Decades [0.03%]
加拿大脑和中枢神经系统癌症发病率的收入和教育不平等：二十年来的趋势变化
Alysha Roberts,Min Hu,Mohammad Hajizadeh
Alysha Roberts
The socioeconomic gradient of brain and central nervous system (CNS) cancer incidence in Canada is poorly understood. This study aimed to measure socioeconomic inequalities in brain and CNS cancer incidence in Canada from 1992 to 2010. Usin...
The Role of Sex-specific Long Non-coding RNAs in Cancer Prevention and Therapy [0.03%]
性特异性长链非编码RNA在癌症防治中的作用
Hye Kyung Song,Sun Young Kim
Hye Kyung Song
The functions of a large number of non-coding genes in human DNA have yet to be accurately identified. Long non-coding RNA (lncRNA) measuring 10 kb or less in length regulates transcription or post-transcriptional events. The lncRNAs have a...