Fecal Microbial Enterotypes Differentially Respond to a High-fat Diet Based on Sex in Fischer-344 Rats [0.03%]
基于性别费城344大鼠的粪便微生物亚型对高脂饮食反应不同
Soo In Choi,Nayoung Kim,Ryoung Hee Nam et al.
Soo In Choi et al.
The gut microbiota interacts with the host gut environment, which is influenced by such factors as sex, age, and host diet. These factors induce changes in the microbial composition. The aim of this study was to identify differences in the ...
Comparative Pre-clinical Efficacy of Chinese and Indian Cultivars of Bitter Melon (Momordica charantia) against Pancreatic Cancer [0.03%]
苦瓜（葫芦科植物）的临床前抗胰腺癌疗效的比较研究：中国种和印度种
Kushal Kandhari,Sandeep Paudel,Komal Raina et al.
Kushal Kandhari et al.
Given the high rates of incidence and mortality associated with pancreatic cancer (PanC), there is a need to develop alternative strategies to target PanC. Recent studies have demonstrated that fruits of bitter melon (Momordica charantia) e...
Evaluation of the Value of Multiplex MicroRNA Analysis as a Breast Cancer Screening in Korean Women under 50 Years of Age with a High Proportion of Dense Breasts [0.03%]
在高密度乳腺的韩国年轻女性中评估多重微小核糖核酸分析作为乳腺癌筛查的价值
Ji Young Jang,Eun Young Ko,Ji Soo Jung et al.
Ji Young Jang et al.
This study was conducted to confirm the performance of the microRNA (miRNA) biomarker combination as a new breast cancer screening method in Korean women under the age of 50 with a high percentage of dense breasts. To determine the classifi...
Association of High Expression of Mitochondrial Fission Regulator 2 with Poor Survival of Patients with Esophageal Squamous Cell Carcinoma [0.03%]
线粒体分裂调节因子2高表达与食管鳞癌患者预后不良相关性分析
Hongwei Li,Xingzhuang Zhu,Wei Zhang et al.
Hongwei Li et al.
Mitochondrial fission regulator 2 (MTFR2) is associated with mitochondrial fission, while few studies have assessed the associations between MTFR2 expression and clinical characteristics or prognosis of esophageal squamous cell carcinoma (E...
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles [0.03%]
含铁载铁蛋白在胞外囊泡中的双刃剑作用
Shinya Toyokuni,Yingyi Kong,Hao Zheng et al.
Shinya Toyokuni et al.
Human epidemiological and animal studies have demonstrated that excess iron is a risk for cancer. The responsible mechanisms are: 1) increased intracellular iron catalyzes the Fenton reaction to generate hydroxyl radicals, leading to mutage...
Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression [0.03%]
支链氨基酸代谢在肿瘤发生和发展中的作用
Min Kyu Jung,Akinkunmi Paul Okekunle,Jung Eun Lee et al.
Min Kyu Jung et al.
Branched-chain amino acids (BCAAs), isoleucine, leucine and valine, are essential amino acids with vital roles in protein synthesis and energy production. We reviewed the fundamentals of BCAA metabolism in advanced cancer patients. BCAAs an...
Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy [0.03%]
卡里限制在癌症预防和治疗中的作用：机制、期望及疗效
Chiara Vidoni,Alessandra Ferraresi,Andrea Esposito et al.
Chiara Vidoni et al.
Cancer is one of the most frequently diagnosed diseases, and despite the continuous efforts in searching for new and more effective treatments, its morbidity and mortality remain a significant health problem worldwide. Calorie restriction, ...
The 50-Year War on Cancer Revisited: Should We Continue to Fight the Enemy Within? [0.03%]
重审抗癌50年战争：我们还要继续与体内的敌人作战吗？
Young-Joon Surh
Young-Joon Surh
STAT3 as a Potential Target for Tumor Suppressive Effects of 15-Deoxy-Δ12,14-prostaglandin J2 in Triple Negative Breast Cancer [0.03%]
15-脱氧-Δ12,14-前列腺素J2在三阴性乳腺癌中的肿瘤抑制效应的潜在靶点STAT3
Su-Jung Kim,Nam-Chul Cho,Young-Il Hahn et al.
Su-Jung Kim et al.
STAT3 plays a prominent role in proliferation and survival of tumor cells. Thus, STAT3 has been considered to be a prime target for development of anti-cancer therapeutics. The electrophilic cyclopentenone prostaglandin,15-deoxy-Δ12,14-pro...
Docosahexaenoic Acid Inhibits Cytokine Expression by Reducing Reactive Oxygen Species in Pancreatic Stellate Cells [0.03%]
二十二碳六烯酸通过减少胰星状细胞的活性氧来抑制细胞因子表达
Sun Ah Chung,Joo Weon Lim,Hyeyong Kim
Sun Ah Chung
Pancreatic stellate cells (PSCs) are activated by inflammatory stimuli, such as TNF-α or viral infection. Activated PSCs play a crucial role in the development of chronic pancreatitis. Polyinosinic-polycytidylic acid (poly (I:C)) is struct...