Relative efficacy of systemic treatments for patients with relapsed/refractory chronic lymphocytic leukemia: a network meta-analysis according to 17p deletion/TP53 mutations [0.03%]
复发/难治性慢性淋巴细胞白血病伴或不伴有17p缺失/TP53突变的系统治疗药物的网状meta分析疗效比较研究
Jinchul Kim,Jinhyun Cho,Joo Han Lim et al.
Jinchul Kim et al.
Purpose: This network meta-analysis aimed to evaluate the relative efficacy of systemic treatments in patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL), focusing on key genetic mutations, specifical...
RAD51 and RAD50 genetic polymorphisms from homologous recombination repair pathway are associated with disease outcomes and organ toxicities in AML [0.03%]
同源重组修复通路中的RAD51和RAD50基因多态性与AML患者的预后及器官毒性相关性研究
Alireza Mohseni,Gholamreza Toogeh,Shahrbano Rostami et al.
Alireza Mohseni et al.
Background: Acute myeloid leukemia (AML) is a heterogeneous malignancy that responds to various therapies. The sensitivity of leukemia cells to chemotherapy is affected by the DNA damage response (DDR). In this study, we ...
Incidence and outcomes of subsequent malignancy after allogeneic hematopoietic stem cell transplantation in adult patients with severe aplastic anemia [0.03%]
严重获得性再生障碍性贫血成人患者异基因造血干细胞移植后继发恶性肿瘤的发病及转归研究
Daehun Kwag,Sung-Soo Park,Sung-Eun Lee et al.
Daehun Kwag et al.
Purpose: This study investigated the occurrence of subsequent malignancies (SM) in adult patients with severe aplastic anemia (SAA) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) to address the lack ...
Strategies for integrating ChatGPT and generative AI into clinical studies [0.03%]
将ChatGPT和生成型人工智能整合到临床研究中的策略
Jeong-Moo Lee
Jeong-Moo Lee
Large language models, specifically ChatGPT, are revolutionizing clinical research by improving content creation and providing specific useful features. These technologies can transform clinical research, including data collection, analysis...
Bone marrow mesenchymal stem cell exosomes suppress JAK/STAT signaling pathway in acute myeloid leukemia in vitro [0.03%]
骨髓间充质干细胞外泌体通过抑制JAK-STAT信号通路体外抑制急性髓系白血病
Sahar Jalilivand,Maryam Nabigol,Mehdi Bakhtiyaridovvombaygi et al.
Sahar Jalilivand et al.
Introduction: Despite advances in the treatment of acute myeloid leukemia (AML), refractory forms of this malignancy and relapse remain common. Therefore, development of novel, synergistic targeted therapies are needed ur...
Increased IDO expression and regulatory T cells in acute myeloid leukemia: implications for immune escape and therapeutic targeting [0.03%]
急性髓系白血病中IDO表达和调节性T细胞的增加：对免疫逃逸和靶向治疗的意义
Raziyeh Hakak,Behzad Poopak,Ahmad Majd
Raziyeh Hakak
Purpose: This study aimed to determine the frequency of regulatory T cells (Tregs) (CD4+/FOXP3+) and indoleamine 2,3-dioxygenase (IDO) expression in patients with acute myeloid leukemia (AML). ...
Acute myeloid leukemia and myelodysplastic neoplasms: clinical implications of myelodysplasia-related genes mutations and TP53 aberrations [0.03%]
急性髓系白血病和髓系肿瘤的临床意义：与发育不良相关基因突变及TP53异常的关系
Hyunwoo Kim,Ja Young Lee,Sinae Yu et al.
Hyunwoo Kim et al.
Purpose: The fifth World Health Organization (WHO) classification (2022 WHO) and International Consensus Classification (ICC) of myeloid neoplasms have recently been published. In this study, patients were reclassified ac...
Evaluating histone H3.1 as a biomarker for acute ischemic stroke: insights into NETs and stroke pathophysiology [0.03%]
组蛋白H3.1作为急性缺血性卒中生物标志物的评估：关于NETs和卒中病理生理学的新见解
Suji Park,Jae-Ryong Shim,Ri-Young Goh et al.
Suji Park et al.
The diagnosis of acute ischemic stroke (AIS) can be challenging when neuroimaging findings are normal or equivocal. Neutrophil extracellular traps (NETs), particularly histone H3.1, have potential as biomarkers for AIS. This study evaluated...
Taner Tan,Sinem Civriz Bozdag
Taner Tan
Understanding the intricacies of the pathophysiology and genomic landscape has enhanced the long-term outcomes for patients with acute myeloid leukemia (AML). The identification of novel molecular targets has introduced new therapeutic stra...