Alcohol-induced oxidative stress triggers mitochondrial Ca²⁺ release through the permeability transition pore [0.03%]
酒精引起的氧化应激通过通透性转换孔诱导线粒体钙释放
Kwangwoo Lee,Jiyoon Lee,Jihyo Byun et al.
Kwangwoo Lee et al.
HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma [0.03%]
HKDC1介导的多胺重组驱动肝细胞癌仑伐替尼耐药和免疫逃逸
Shiping Chen,Biao Wang,Yang Zhang et al.
Shiping Chen et al.
Background/aims: Lenvatinib resistance and immune exclusion limit outcomes in HCC. We hypothesized that metabolic rewiring orchestrates resistance to lenvatinib and PD-1 blockade. ...
Preclinical pharmacology and toxicology study of an AAV8-tATP7B vector for Wilson's disease [0.03%]
AAV8-tATP7B治疗威尔逊病的药理和毒理学研究
Zixuan Wang,Mengyu Wang,Mengyuan Wu et al.
Zixuan Wang et al.
Background and aims: Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. In this study, a novel gene therapy for WD was developed, and its efficacy and safety were eval...
Oncofetal reprogramming in hepatocellular carcinoma: Linking developmental programs to cancer vaccines and immunotherapy [0.03%]
肝癌的肿瘤胚胎重编程：将发育程序与癌症疫苗和免疫治疗联系起来
Dayangku Nordiyana B P Hassanel,Ankur Sharma
Dayangku Nordiyana B P Hassanel
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer mortality worldwide. Its pathogenesis reflects a combination of tumour-intrinsic heterogeneity and a profoundly immunosuppressive tumour mi...
Seroepidemiology of HBV infection in apparently healthy adults in China: a nationwide study based on 17 million check-up adults [0.03%]
中国体检成人乙肝病毒感染血清流行病学调查：基于1700万例调查对象的全国性研究
Sailimai Man,Zhuoyan Yu,Jing Du et al.
Sailimai Man et al.
Extrahepatic Mortality associated with Chronic Liver Disease with or without Cirrhosis from 2014 to 2024 [0.03%]
2014至2024年慢性肝病伴或不伴有肝硬化的肝外死亡率
Donghee Kim,Pojsakorn Danpanichkul,Karn Wijarnpreecha et al.
Donghee Kim et al.
GAFAD: An LC-MS/MS-Based Model for Early Hepatocellular Carcinoma Detection Beyond GALAD's Limitation [0.03%]
基于LC-MS/MS的GAFAD模型用于克服GALAD局限性的肝细胞癌早期检测模型
Hyojin Kim,Wonseok Oh,Juri Park et al.
Hyojin Kim et al.
Background/aims: The GALAD (Gender, Age, Lens culinaris agglutinin-reactive alpha-fetoprotein [AFP-L3], alpha-fetoprotein [AFP], and des-γ-carboxy prothrombin [DCP]) score, widely used for hepatocellular carcinoma (HCC) ...
Emerging Therapeutic Regimens as Alternatives to Glucocorticoids for Severe Alcohol-Associated Hepatitis: A Comprehensive Review [0.03%]
非糖皮质激素治疗严重酒精性肝炎的新疗法：全面回顾式研究
Rahul Kumar,Sakktivel Elangovan,Sumeet Asrani
Rahul Kumar
Severe alcohol-associated hepatitis (SAH) is the most aggressive form of alcohol-associated liver disease and is associated with very high short-term mortality. It is characterized by the acute onset of jaundice in the context of ongoing al...
IL-1β as Target to Induce Synthetic Lethality in KRAS Mutant Biliary Tract Cancer [0.03%]
靶向白细胞介素-1β在KRAS突变型胆道癌中诱导合成致死性
Shijie Li,Yukai Shan,Tianen Chen et al.
Shijie Li et al.
Background: Biliary tract cancer (BTC) frequently harbors KRAS mutations, which are associated with resistance to traditional treatment and a poor prognosis. Synthetic lethality (SL) strategy may provide other targets of ...