Combination Antiangiogenic and Immunotherapy for Advanced Hepatocellular Carcinoma: Evidence to Date [0.03%]
晚期肝细胞癌的联合抗血管生成和免疫治疗：到目前为止的证据
Alison L Raybould,Hanna Sanoff
Alison L Raybould
For over a decade, sorafenib remained the only systemic agent with proven clinical efficacy for patients with advanced hepatocellular carcinoma (HCC). Recent years have seen a proliferation of agents. In the first line, lenvatinib was found...
Survival Outcomes for Yttrium-90 Transarterial Radioembolization With and Without Sorafenib for Unresectable Hepatocellular Carcinoma Patients [0.03%]
钇90放射性微球结合索拉非尼在无法切除的肝细胞癌患者中的应用及生存结果分析
Ajalaya Teyateeti,Armeen Mahvash,James P Long et al.
Ajalaya Teyateeti et al.
Purpose: To assess the overall survival (OS) and progression-free survival (PFS) of unresectable hepatocellular carcinoma (HCC) patients undergoing yttrium-90 glass-microsphere transarterial radioembolization (TARE) with ...
Resection of NAFLD-Associated HCC: Patient Selection and Reported Outcomes [0.03%]
与NAFLD相关的HCC切除术：患者选择和报告的结果
Claudia Campani,Carolina Bensi,Stefano Milani et al.
Claudia Campani et al.
Global prevalence of non-alcoholic fatty liver disease (NAFLD) has been growing in the last decades, especially in western countries, due to increased prevalence of diabetes, obesity or other components of metabolic syndrome. NAFLD recently...
Inflammation-Based Prognostic Scores in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma After Liver Transplantation [0.03%]
肝脏移植后炎症反应为基础的乙肝相关肝细胞癌预后评分系统
Ao Ren,Zhongqiu Li,Xuzhi Zhang et al.
Ao Ren et al.
Background: Inflammation-based prognostic scores including systemic immune-inflammation index (SII), platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) have prognostic value in various cancers. We...
Profile of Cabozantinib for the Treatment of Hepatocellular Carcinoma: Patient Selection and Special Considerations [0.03%]
卡博替尼治疗肝细胞癌的患者选择及特殊考量述评
Audrey Debaillon Vesque,Marie Decraecker,Jean-Frédéric Blanc
Audrey Debaillon Vesque
Management of advanced hepatocellular carcinoma is challenging. With an increasing number of options for the first and second-line treatment, understanding and developing optimal systemic treatment strategies are crucial. In second line, tw...
Angiogenesis in Hepatocellular Carcinoma; Pathophysiology, Targeted Therapy, and Role of Imaging [0.03%]
肝细胞癌的新生血管形成：病理生理、靶向治疗和影像学的作用
Ahmed W Moawad,Janio Szklaruk,Chandana Lall et al.
Ahmed W Moawad et al.
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide, usually occurring on a background of liver cirrhosis. HCC is a highly vascular tumor in which angiogenesis plays a major role in tumor growth and spread. Tumor-induc...
Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment [0.03%]
与慢性HCV感染相关的肝细胞癌机制及其直接抗病毒治疗的影响
Srikanta Dash,Yucel Aydin,Kyle E Widmer et al.
Srikanta Dash et al.
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be highly complex due to the decade-long interactions betw...
Enrique Boldo,Ana Santafe,Araceli Mayol et al.
Enrique Boldo et al.
Introduction: Besides more common sites such as lung or peritoneum, hepatocellular carcinoma (HCC) can metastatize to rare sites. We report herein a new metastatic site of HCC: the nail-bed. We also review other recently ...
Impact of Next-Generation Sequencing on Outcomes in Hepatocellular Carcinoma: How Precise Are We Really? [0.03%]
下一代测序对肝细胞癌预后的影响：我们真的那么精确吗？
Dana A Dominguez,Xin Wei Wang
Dana A Dominguez
Advances in Next-Generation Sequencing (NGS) technology have led to a rapid expansion in the application of "precision medicine," attempting to personalize therapies and improve outcomes for cancer patients. While these technologies carry g...
Experimental Study of Hepatocellular Carcinoma Treatment by Shikonin Through Regulating PKM2 [0.03%]
通过调控PKM2研究北豆根素治疗肝癌的作用机制
Tong Liu,Sainan Li,Liwei Wu et al.
Tong Liu et al.
Objective: Shikonin is a natural product with many activities, including anti-cancer effects. Pyruvate kinase type M2 (PKM2) plays a crucial role in the growth of tumor cells. However, the effect of shikonin on PKM2 in he...