Differential Prognostic Impacts of Hepatic Segment VI and VII Involvement in Hepatocellular Carcinoma [0.03%]
肝细胞癌中肝段VI和 VII 淋巴结转移的预后影响不同
Runze Yu,Zhiwen Luo,Hong Zhao et al.
Runze Yu et al.
This study aimed to investigate the impact of hepatic segment distribution on the prognosis of patients with primary hepatocellular carcinoma (HCC). A retrospective analysis was conducted on 456 eligible patients with primary HCC admitted t...
A Single‑Center Retrospective Cohort Study: Impact of Glycemic Control on First‑Line TKI Plus PD‑1 Inhibitors versus TKI Alone in Intermediate‑to‑advanced Unresectable Hepatocellular Carcinoma(HCC) with Type 2 Diabetes Mellitus (T2DM) [0.03%]
单中心回顾性队列研究：血糖控制对一线TKI联合PD-1抑制剂对比TKI单药治疗中期至晚期不可切除的伴有2型糖尿病的肝细胞癌（HCC）的影响
Jiaqi Liu,Xiong Chen,Runxian Wang et al.
Jiaqi Liu et al.
Background and aim: Type 2 diabetes mellitus (T2DM) is an independent risk factor for hepatocellular carcinoma (HCC), and the number of HCC patients with comorbid T2DM is increasing. Although tyrosine kinase inhibitor (TK...
Baseline ALBI Grade as an Independent Prognostic Factor of Survival in High-Risk Real-World HCC Under Atezolizumab-Bevacizumab [0.03%]
ALBI基线分级作为接受阿特珠单抗-贝伐珠单抗治疗的高危真实世界肝细胞癌患者生存预后独立预测因素
Filiz Araz,Fatih Köse,Timuçin Çil et al.
Filiz Araz et al.
Background/aim: Atezolizumab plus bevacizumab is the current first-line standard for unresectable hepatocellular carcinoma (HCC). However, real-world populations often differ substantially from clinical trials particularl...
PTM-Related Signatures Predict Lymph Node Metastasis and Shape Microenvironment in Hepatocellular Carcinoma: A Single-Cell and Bulk Integrated Analysis [0.03%]
基于PTM相关特征预测肝细胞癌淋巴结转移及塑造肿瘤微环境的单细胞与bulk数据集联合分析
Zhu Ai,Yuying Liang,Yuzhi Cai et al.
Zhu Ai et al.
Background: Hepatocellular carcinoma (HCC) has a poor prognosis with lymph node metastasis (LNM), severely impacting survival. Protein post-translational modifications (PTMs) regulate tumor microenvironment (TME) dynamics...
Giant Atypical Hepatocellular Adenoma of Unknown Etiology in a Young Male: A Case Report [0.03%]
病因不明的年轻男性特大非典型肝细胞腺瘤1例报告
Jiaqi Chen,Lingkun Zhang,Kunyu Huang et al.
Jiaqi Chen et al.
We report a case of giant hepatocellular adenoma (HCA) in a 24-year-old man. The patient had no definite known risk factors, and both the clinical manifestations and imaging findings were nonspecific, making preoperative diagnosis difficult...
Adjuvant Sintilimab Plus Bevacizumab After Curative Resection of Spontaneously Ruptured Hepatocellular Carcinoma: Protocol for a Prospective, Exploratory, Single-Arm Study (CLEAR-2) [0.03%]
术后辅助信迪利单抗联合贝伐珠单抗治疗自发性破裂的肝细胞癌：前瞻性探索性单臂研究（CLEAR-2）方案
Yuan Cheng,Feng Ye,Hui-Chuan Sun et al.
Yuan Cheng et al.
Background: Spontaneous rupture of hepatocellular carcinoma (srHCC) is a life-threatening complication associated with high perioperative mortality and increased postoperative recurrence, particularly peritoneal dissemina...
Prognostic Significance of Combined α-Fetoprotein and PIVKA-II for Hepatocellular Carcinoma After Hepatectomy [0.03%]
术前联合甲胎蛋白和PIVKA-II对肝癌患者预后的价值评估研究
Jiajie Wen,Taixin Yang,Mingjian Huang et al.
Jiajie Wen et al.
Purpose: Hepatocellular carcinoma (HCC) exhibits notable prognostic heterogeneity. While AFP is a routine HCC prognostic biomarker, its limited detection rate restricts standalone use. This study aimed to evaluate the pro...
Metabolic Reprogramming-Targeted Therapeutic Strategies in Primary Liver Cancer: A Bibliometric and Visualized Analysis [0.03%]
基于代谢重构的原发性肝癌治疗策略 bibliometric 分析
Qiwei Yang,Lin Yu,Yishan Peng et al.
Qiwei Yang et al.
Background: Metabolic reprogramming has emerged as a critical hallmark and promising therapeutic target in primary liver cancer (PLC), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). H...
Stage-Dependent Efficacy of TACE Combined with Tyrosine Kinase and Immune Checkpoint Inhibitors as Conversion Therapy for Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Study [0.03%]
基于分期的TACE联合靶向和免疫治疗不可切除肝细胞癌新辅助转化疗效的多中心回顾性研究
Haozhe Zhou,Lin Ye,Wanrong Yue et al.
Haozhe Zhou et al.
Purpose: This study was designed to compare the efficacy and safety of transarterial chemoembolization (TACE) alone versus TACE combined with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) as co...
Prognostic Relevance of Neddylation-Related Genes in Hepatocellular Carcinoma [0.03%]
泛素类似物 neddylation 相关基因在肝细胞癌的预后价值研究
Qiyue Sun,Guang Tan
Qiyue Sun
Purpose: Targeting neddylation offers a potential therapeutic strategy for hepatocellular carcinoma (HCC). This retrospective study aims to identify genes linked to HCC prognosis associated with neddylation through bioinf...