Effectiveness and Safety of Eculizumab in Highly Active AChR+gMG and Its Therapeutic Response in Different Subtypes of gMG [0.03%]
Tianying Ma,Yanan Liu,Ying Zhu et al.
Tianying Ma et al.
Background: Eculizumab had been approved for anti-acetylcholine receptor antibody-positive (AChR+) refractory myasthenia gravis (MG), but its effect on the broader group of highly active generalized myasthenia gravis (gMG...
Lymphoproliferation in Inborn Errors of Immunity: Mechanisms, Manifestations and Clinical Management, with a Focus on ALPID [0.03%]
遗传性免疫缺陷病中的淋巴细胞增生：机制、临床表现和管理（重点讨论ALPID）
Giulia Gualtiero,Helena Buso,Eva C Coopmans et al.
Giulia Gualtiero et al.
Lymphoproliferation represents a common and clinically relevant feature across many Inborn Errors of Immunity (IEIs), reflecting the underlying immune dysregulation that characterizes these disorders. In affected individuals, lymphoprolifer...
Recurrent Glioblastoma and the Tumor Immune Landscape: Emerging Immunotherapeutic Strategies [0.03%]
复发性胶质母细胞瘤与肿瘤免疫微环境：新兴的免疫治疗策略
Zixuan Cao,Shurong Tong,Zihan Wang et al.
Zixuan Cao et al.
Glioblastoma (GBM) is the most aggressive malignant tumor affecting the central nervous system. Current standard of care provides only modest clinical benefits, most patients eventually develop tumor recurrence, at which point therapeutic o...
UVB Upregulates Inflammatory Cytokines in Rosacea Cell Model by Promoting the Expression of TRPVs and TLR2 [0.03%]
紫外线B通过促进TRPV和TLR2的表达来上调 rosacea 细胞模型中的炎症细胞因子
Yuming Xie,Yue Hu,Junke Huang et al.
Yuming Xie et al.
Background: The expression of transient receptor potential vanilloid (TRPV) and Toll-like receptor 2 (TLR2) in the lesion sites of patients with rosacea is increased. Ultraviolet B (UVB) radiation can induce inflammation ...
The Comparative Effectiveness of Enlonstobart and Camrelizumab as Second-Line Recurrent or Metastatic Cervical Cancer Therapies: Matching-Adjusted and Simulated Treatment Comparisons [0.03%]
恩洛单托班与卡瑞利珠单抗作为复发或转移性宫颈癌二线疗法的有效性比较：匹配调整和模拟治疗的对比研究
Huiqiao Gu,Bingxin Hu,Yawen Jiang
Huiqiao Gu
Purpose: Recurrent or metastatic cervical cancer (R/M CC) has limited therapeutic options after first-line treatment failure. Both enlonstobart and camrelizumab are anti-PD-1 antibodies recommended for second-line treatme...
Bo Li,Sitong Jiang,Fan Yang et al.
Bo Li et al.
Although tumor immunotherapy has shown significant efficacy against solid tumors, it frequently causes cutaneous and follicular adverse events resulting from disruption of the hair follicle immune microenvironment. This microenvironment is ...
The Dual Mechanism of Action of CO-005 Overcomes CD20 Resistance in Diffuse Large B-Cell Lymphoma [0.03%]
CO-005的双重作用机制可克服弥漫性大B细胞淋巴瘤中CD20的耐药性
Sittana Matar,Seham Skah,Liza E B Moltu et al.
Sittana Matar et al.
Purpose: Despite the clinical success of anti-CD20 monoclonal antibodies (mAbs) such as rituximab in the treatment of B-cell lymphoma, therapeutic resistance and relapse remain significant challenges, particularly in tumo...
Targeting STING Signalling Polarizes Tumor-Associated Neutrophils to Boost Anticancer and Abscopal Antimetastatic Functions [0.03%]
靶向STING信号使肿瘤相关中性粒细胞极化以增强抗癌和远隔抗转移作用
Alina Drzyzga,Justyna Czapla,Tomasz Cichoń et al.
Alina Drzyzga et al.
Introduction: The stimulator of interferon genes (STING) pathway has emerged as a promising target for cancer immunotherapy. Tumor-associated neutrophils (TANs) are underrated among the cells involved in STING-targeted th...
Enhancing NK Cell Activity in Colorectal Cancer with an Fc-Optimized Antibody Targeting CD276 (B7-H3) [0.03%]
通过优化的Fc段抗体靶向CD276（B7-H3）增强结直肠癌中NK细胞活性
Sylwia A Stefańczyk,Xenija Kaiser,Ilona Hagelstein et al.
Sylwia A Stefańczyk et al.
Background & aims: Colorectal cancer (CRC) represents a major global health burden due to its high incidence and mortality, particularly in the advanced stages, with limited treatment options. While therapies that block t...
Identification of Comprehensive Landscape of Peripheral Immunity and Chemokine-Related Genes in Amyotrophic Lateral Sclerosis [0.03%]
肌萎缩侧索硬化外周免疫全景和细胞因子相关基因的识别
Xinyu Yang,Sen Huang,Yuxin Wang et al.
Xinyu Yang et al.
Purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive loss of motor neuron function and disruption of the blood-brain barrier are key features of ALS. Under the influence of chemok...