Probiotics for managing non-alcoholic fatty liver disease: efficacy and mechanistic insights [0.03%]
益生菌对非酒精性脂肪肝病的疗效及机制研究
Supriyo Ghosh,Amlan Jyoti Ghosh,Manab Deb Adhikari et al.
Supriyo Ghosh et al.
Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by excess fat accumulation in the liver unrelated to alcohol consumption. Emerging scientific research suggests that probiotics supplementation is a useful therapeutic s...
Gut microbiota, sarcopenia, and type 2 diabetes: a triangular pathophysiological network [0.03%]
肠道微生物群、肌少症和2型糖尿病：病理生理网络
Firdaus Jawed,Rabia Aziz,Sajad Ul Islam Mir et al.
Firdaus Jawed et al.
Purpose: Type 2 diabetes mellitus (T2DM), sarcopenia, and gut microbiota dysbiosis are increasingly recognized as interrelated conditions. T2DM accelerates muscle wasting through insulin resistance, inflammation, and oxid...
Cross-sectional association of the metabolic score for insulin resistance with hypertension in multi-ethnic patients with premature coronary artery disease: the IPAD study [0.03%]
用于评估代谢性胰岛素抵抗与多民族早发冠心病患者高血压关联的截面研究：IPAD 研究
Mehrdad Rabiee Rad,Bahar Darouei,Ehsan Zarepur et al.
Mehrdad Rabiee Rad et al.
Purpose: The relationship between the metabolic score for insulin resistance (METS-IR) and cardiometabolic risk factors in premature coronary artery disease (PCAD) is unclear. This study aimed to investigate the associati...
AMPK as a central regulator of metabolic memory: mechanisms and therapeutic opportunities [0.03%]
AMPK作为代谢记忆的核心调节因子：机制和治疗机会
Wajid Aslam Khan,Sourbh Suren Garg,Kaneeka Banyal et al.
Wajid Aslam Khan et al.
Adenosine monophosphate-activated protein kinase (AMPK) is a conserved serine/threonine kinase that acts as a central regulator of cellular energy homeostasis. Activated by an elevated AMP/ATP or ADP/ATP ratio under energy-depleting conditi...
Hepcidin levels in healthy young adults: Findings from a systematic review and meta-analysis of reference intervals [0.03%]
健康青年人肝肽素水平的系统评价和meta分析研究结果
Paola Moreno Lozano,Lilia Angélica Hurtado Ayala,Francisco Guillermo Mendoza-Hoffmann et al.
Paola Moreno Lozano et al.
Background/objectives: The identification of the hormone hepcidin has significantly advanced our understanding of the homeostatic mechanisms and pathogenic processes associated with iron metabolism disorders. This review ...
Discontinuation of aspirin for primary prevention and increased risks of cardiovascular disease in a descriptive study from Thailand [0.03%]
泰国描述性研究：阿司匹林在一级预防中的停用与心血管疾病风险增加的关系
Kraisit Phakwiwat,Korawee Matesareyapong,Thanapat Limpaarayakul et al.
Kraisit Phakwiwat et al.
Background: The role of aspirin for primary prevention remains debated, especially around discontinuation in Thailand. Western studies suggest higher cardiovascular risk after cessation, but Southeast Asian evidence is li...
Glycated CD59: an emerging biomarker of diabetic nephropathy associated with microalbuminuria, tubular damage, and complement activation [0.03%]
糖化CD59：与微量白蛋白尿、肾小管损伤和补体活化相关的糖尿病肾病新兴生物标志物
Bhagatsingh Chinta,Sunethri Padma,Ranga Rao Ambati
Bhagatsingh Chinta
Background: Diabetic nephropathy (DN) remains a major complication of type 2 diabetes mellitus (T2D). Conventional markers such as albuminuria and HbA1c have limited value for early prediction. Plasma glycated CD59 (gCD59...
Inhibitory effects of water chestnut (Trapa bispinosa Roxb.) extract plus lutein on the progression of cataract and their impact on the retina and aorta in diabetic rats [0.03%]
莲子草(Trapa bispinosa Roxb)提取物联合叶黄素对糖尿病大鼠白内障的影响及对视网膜和主动脉的作用研究
Hiroshi Mizuno,Gaku Ishigooka,Denan Jin et al.
Hiroshi Mizuno et al.
Purpose: Trapa bispinosa Roxb. extract (TBE), combined with lutein, has an inhibitory effect on cataract progression. However, no prior studies evaluated oxidative stress- and antioxidant-related factors simultaneously. T...
Re-evaluating higher age as a risk factor for diabetes in the Indian population: the emergence of young-onset type 2 diabetes [0.03%]
印度人群中重新评估高龄作为糖尿病的风险因素：年轻发病2型糖尿病的出现
Paras Agarwal,Anjana Bhan,Aditi Saini et al.
Paras Agarwal et al.
This study re-evaluates the traditional emphasis on higher age as a primary risk factor for diabetes in the Indian population, highlighting the increasing prevalence of Young-Onset Type 2 Diabetes (YOD) among younger individuals. Despite be...
Possibilities and challenges of next-generation therapeutics: solid lipid nanoparticles revolutionizing metabolic disorder treatment [0.03%]
下一代治疗的机遇与挑战——固体脂质纳米颗粒技术革新代谢性疾病治疗
Sameer Iqbal,Hammad Ahmed,Faiza Rafique et al.
Sameer Iqbal et al.
Purpose: Metabolic disorders (obesity, diabetes mellitus, hyperlipidemia) represent a major and escalating global health burden. Conventional pharmacological therapies face limitations, including poor bioavailability, sys...