Pathogenesis mechanism of ferroptosis and pharmacotherapy in kidney diseases: a review [0.03%]
铁死亡的肾病发病机制及药物治疗：综述性文章
Lan Li,Heping Zhang,Jincheng Tang
Lan Li
Background: Ferroptosis is a novel form of iron-dependent programmed cell death, characterized by lipid peroxidation and the accumulation of reactive oxygen species. Dysregulation of iron metabolism, lipid metabolism, or ...
Review
Nephron. 2025 Apr 24:1-22. DOI:10.1159/000545387 2025
Claudia Carrera,Delphine Kervella,Elena Crespo et al.
Claudia Carrera et al.
Over the past decade, important advancements in the understanding of transplant physiopathology and refinement of immunosuppressive strategies have been achieved. Yet, this has not been translated into significant improvement on graft and p...
Review
Nephron. 2025 Apr 23:1-25. DOI:10.1159/000545425 2025
Renzo Mignani,Gian Marco Berti,Gisella Vischini et al.
Renzo Mignani et al.
Background: Fabry disease (FD) is a rare, X-linked lysosomal storage disorder that affects both males and females. It is caused by pathogenic variants in the gene that encodes the enzyme α-galactosidase A, GLA. The class...
Review
Nephron. 2025 Apr 4:1-11. DOI:10.1159/000545611 2025
Relapse Risk in Patients with Membranous Nephropathy after Inactivated COVID-19 Vaccination [0.03%]
COVID-19疫苗接种后膜性肾病患者的复发风险
Hanzhen Zhang,Ruiying Chen,Mingyue Xu et al.
Hanzhen Zhang et al.
Background: Although there have been reports of relapse or worsening of membranous nephropathy after receiving vaccines against coronavirus disease 2019 (COVID-19), the causal relationship or association between them has ...
Can-SOLVE CKD: reflections on successes, challenges, and future opportunities in patient-oriented kidney research [0.03%]
加拿大CAN-_solve CKD：以患者为导向的肾脏病研究的成功、挑战与未来机遇反思
Melanie D Talson,Michelle Hampson,Kelly Loverock et al.
Melanie D Talson et al.
Further Clinical and Biochemical Phenotype of GLA p.A143T: a Fabry Disease Newborn Screening Experience [0.03%]
进一步临床和生化表型的GLA p.A143T: 果糖病新生儿筛查体验
Allison M Paltzer,Allegra M Quadri,Carly Rasmussen et al.
Allison M Paltzer et al.
Background: In 2015, Illinois added Fabry disease to the newborn screening (NBS) panel, and numerous individuals who have the controversial p.A143T GLA variant were identified. Ann & Robert H. Lurie Children's Hospital of...
Review
Nephron. 2025 Mar 28:1-14. DOI:10.1159/000543920 2025
Dapagliflozin Treatment Attenuates the Interaction Between the Renal Sodium Chloride co-transporter and Ezrin in Hypertensive Diabetic db/db Mice [0.03%]
dapagliflozin治疗减轻了糖尿病db/db小鼠中高血压状态下肾钠氯协同转运蛋白和ezrin的相互作用
Mohammed F Gholam,Abdel A Alli
Mohammed F Gholam
Introduction: Ezrin is a protein that links the actin cytoskeleton to membrane proteins. The sodium chloride cotransporter (NCC) plays a key role in regulating total body electrolyte homeostasis and systemic blood pressur...
Laura G Sanchez-Lozada,Miguel A Lanaspa,Bernardo Rodriguez-Iturbe et al.
Laura G Sanchez-Lozada et al.
The use of SGLT2 inhibitors have had remarkable success in the management of chronic kidney disease, by both slowing progression and reducing cardiovascular mortality. Among their many actions, SGLT2 inhibitors have also been found to lower...
Correlation between plasma aldosterone concentrations and simple renal cyst in hypertensive patients [0.03%]
高血压患者血浆醛固酮浓度与简单性肾囊肿的相关性研究
Huimin Ma,Xintian Cai,Shuaiwei Song et al.
Huimin Ma et al.
Background: Previous studies have linked primary aldosteronism to simple renal cysts (SRC), but the relationship between plasma aldosterone concentration (PAC) and SRC remains unclear. This study aimed to investigate the ...
Lysosomal storage-independent Fabry disease variants with α-galactosidase A misprocessing-induced ER stress and the unfolded protein response [0.03%]
溶酶体贮积独立的法布里病变异型具有由α-半乳糖苷酶A错误加工诱导的内质网应激和未折叠蛋白反应
Martina Živná,Malte Lenders,Stanislav Kmoch
Martina Živná
Background: Clinical findings in Fabry disease have classically been attributed to loss-of- function variants in the GLA gene that result in α-galactosidase A deficiency, intracellular accumulation of globotriaosylcerami...
Review
Nephron. 2025 Mar 20:1-17. DOI:10.1159/000545388 2025