Wernicke's encephalopathy following radical gastrectomy and prolonged parenteral nutrition: a case report of pyloric obstruction and undisclosed psychiatric comorbidity [0.03%]
全胃切除及长期肠外营养后发生韦尼克脑病一例报告及相关幽门梗阻和未披露的精神共患病关系分析
Hanchen Ma,Zheng Zhao,Wenjie Zhang et al.
Hanchen Ma et al.
Wernicke's encephalopathy (WE), a neuropsychiatric emergency caused by thiamine deficiency, is increasingly recognized in nonalcoholic populations. We present a 64-year-old male with pyloric obstruction from gastric cancer (stage IIIA) who ...
Current trends and future projection for addressing the burden of esophageal carcinoma in Asia: a comprehensive analysis (1990-2040) [0.03%]
亚洲食管癌负担的现状趋势与未来预测（1990-2040）：全面分析
Peng Ma,Xiaohong Tan,Tingting Hao et al.
Peng Ma et al.
Background: Esophageal carcinoma (EC) significantly impacts global health, particularly in Asia, where many low- and middle-income countries face substantial burdens despite advancements in some regions. ...
CD16 and Siglec expression refine the phenotypic heterogeneity of steady-state myeloid-derived suppressor cells [0.03%]
CD16和Siglec的表达精确了稳态髓样衍生抑制细胞表型异质性
Chris D St Laurent,Zeinab Jame-Chenarboo,Alyssa E Beck et al.
Chris D St Laurent et al.
Background: Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) mediate cancer immune suppression by promoting an immunosuppressive microenvironment that inhibits effective anti-tumor immunity. However, they ar...
Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection [0.03%]
病例报告：一例罕见的巨大的非AMPULLA OF VATER十二指肠腺瘤采用杂交内镜粘膜下挖除术安全有效的切除
Jun-Jie Hou,Liang Ding,Yan-Fei Yang et al.
Jun-Jie Hou et al.
Background: As a rare condition, sporadic non-ampullary duodenal adenomas (SNADAs) are typically asymptomatic and diagnosed incidentally. It warrants treatment due to the high risk of malignant transformation. However, gi...
PP1γ promotes esophageal squamous cell carcinoma progression through the PP1γ/YAP1/SOX2 axis [0.03%]
PP1γ通过PP1γ/YAP1/SOX2轴促进食管鳞癌进展
Juan Du,Li Liu,Shutao Zheng et al.
Juan Du et al.
Introduction: Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor outcomes and limited targeted therapeutic options. While protein phosphatase 1γ (PP1γ) is overexpressed in various canc...
In silico design and in vitro validation of a multi-epitope peptide vaccine targeting triple-negative breast cancer [0.03%]
基于计算设计并实验验证的三阴性乳腺癌多表位肽疫苗
Pengjun Zhou,Xing Shi,Jinquan Xia et al.
Pengjun Zhou et al.
Aims and objectives: This study aimed to identify immunodominant epitopes from a panel of triple-negative breast cancer (TNBC)-associated proteins-MZF-1, Mucin-1, SOX-9, Keratin 5, Keratin 14, Twist1, and Progranulin (GP8...
Hsa_circ_0018909 promotes non-small cell lung cancer by directly regulating hsa-miR-513b-5p [0.03%]
circRNA hsa_circ_0018909通过直接调控hsa-miR-513b-5p促进非小细胞肺癌进展
Qi Liu,Yong-Kui Yu,Hao-Miao Li et al.
Qi Liu et al.
Background: Circular RNAs (circRNAs) regulate gene expression by functioning as competing endogenous RNAs (ceRNAs) and are increasingly recognized for their involvement in cancer progression. Hsa_circ_0018909 is upregulat...
Revolutions at the frontline of multiple myeloma treatment: lessons and challenges to finding a cure [0.03%]
多发性骨髓瘤治疗前沿的革命：寻找治愈之路上的经验与挑战
Jeries Kort,Andrea Rivera,Sindhuja Senigarapu et al.
Jeries Kort et al.
Multiple myeloma (MM) is a cancer of bone marrow plasma cells. A noteworthy ensemble of therapies has been introduced over the past quarter century that exert antimyeloma activities through diverse mechanisms and achieve durable disease con...
Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies [0.03%]
肿瘤相关成纤维细胞：聚焦于实体瘤与血液系统恶性肿瘤
Chengyun Pan,Lin Zheng,Jishi Wang
Chengyun Pan
The co evolution of tumor cells and microenvironmental matrix components almost determines the series of processes involved in cancer occurrence and progression. However, many anti-cancer treatments are designed around tumor cells, neglecti...
Multi-omics profiling of TGF-β isoforms and regulatory miRNAs in astrocytic tumors reveals TGF-β-3 as a prognostic biomarker [0.03%]
转化生长因子-β异构体和调控性miRNA的多组学谱分析揭示了TGF-β-3是星形胶质瘤预后的生物标志物
Klaudia Skóra,Damian Strojny,Dawid Sobański et al.
Klaudia Skóra et al.
Background: Astrocytic tumors, particularly glioblastomas, are aggressive brain malignancies with poor prognosis. Transforming growth factor-beta (TGF-β) isoforms-TGF-β-1, TGF-β-2, and TGF-β-3-play critical roles in g...