Decoding estrogen receptor and GPER biology: structural insights and therapeutic advances in ERα-positive breast cancer [0.03%]
雌激素受体和GPER生物学的解码：ERα阳性乳腺癌的结构洞察与治疗进展
Taniya Saha,Kiven Erique Lukong
Taniya Saha
Classical estrogen receptors, ERα and ERβ, along with the membrane-bound G-protein-coupled estrogen receptor (GPER), play critical roles in driving ERα-positive breast cancer (BC). Clinical management of this subtype relies on endocrine ...
The human microbiota: a double-edged sword against the 'Sword of Damocles' in PDAC diagnosis and therapy [0.03%]
人类微生物组：一把双刃剑，在PDAC诊断和治疗的“达摩克利斯之剑”面前发挥作用
Maria Sindaco,Leonardo Mercanti,Valentina Puca et al.
Maria Sindaco et al.
Pancreatic Ductal Adenocarcinoma (PDAC) is currently a major oncological threat given the very low 5-year survival rates of 8-9%. The tumor itself is intertwined with its surrounding tissue in a peculiar tumoral microenvironment (TME) which...
A giant angiomyolipoma arising from the hepatic round ligament: a case report and literature review [0.03%]
肝圆韧带来源的巨大血管平滑肌脂肪瘤一例并文献复习
Hai-Bo Zheng,Xiang-Qian Wang,Xian-Ni Liu et al.
Hai-Bo Zheng et al.
Angiomyolipoma (AML) is a type of tumor of mesenchymal origin that is most commonly found in the kidney, although it has been found in the liver in rare cases. Herein, we document the first known instance of an AML identified within the liv...
Investigating the correlation between tertiary lymphoid structures and clinical outcomes in pancreatic ductal adenocarcinoma: insights into tumor immunology [0.03%]
胰腺导管腺癌中三级淋巴组织与临床结局相关性的研究：肿瘤免疫学的新见解
Lingbo Hu,Yanhong Xiao,Ning Jiang et al.
Lingbo Hu et al.
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis and high mortality rates, necessitating the identification of reliable biomarkers for patient stratification. This study investigates the prognostic significance and ...
Narjust Florez,Lauren Kiel,Rebekah Kaufman et al.
Narjust Florez et al.
Background: Young patients with lung cancer represent a distinct population, with unique disease and treatment-related characteristics, as well as psychosocial and survivorship needs. Nevertheless, this population remains...
Sex differences in toxicity and outcomes in patients with sarcoma treated in the perioperative setting at a comprehensive cancer center [0.03%]
肿瘤中心围手术期收治的肉瘤患者的毒性差异及转归研究
Ilaria Tortorelli,Benedetta Chiusole,Fabio Murtas et al.
Ilaria Tortorelli et al.
Background: There is an unmet need of personalized strategies taking into account the influence of sex on treatment. Toxicities commonly lead to dose reductions or delays, which may impact outcomes. The current retrospect...
Neoadjuvant chemotherapy versus long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis of 5,168 cases [0.03%]
术前化疗与长时间的术前放化疗治疗局部晚期直肠癌：包含5168例的系统性回顾及荟萃分析
Wenjie Zhou,Xueting Wang,Jie Dan et al.
Wenjie Zhou et al.
Background: Long-course neoadjuvant chemoradiotherapy (Lc-NCRT) is the conventional treatment for locally advanced rectal cancer (LARC). It improves R0 resection rate and reduces local recurrence rate, but it cannot impro...
CRP/albumin ratio and WBC values correlate with Ki-67 and survival in glioblastoma multiforme [0.03%]
C反应蛋白/白蛋白比值和外周血白细胞计数与胶质母细胞瘤患者Ki-67表达及生存期的关系
Güven Gürsoy
Güven Gürsoy
Introduction: Glioblastoma multiforme (GBM) is an aggressive central nervous system tumor that results in poor overall survival due to its rapid and aggressive course. Prognostic indicators are important in treatment stra...
The m6A modification of LINC01133 suppresses ER+ breast cancer progression by modulating IGF2BP2 protein stability via a ubiquitination-dependent mechanism [0.03%]
LINC01133的m6A修饰通过泛素依赖机制调控IGF2BP2蛋白稳定性抑制ER+乳腺癌进展
Mai-Dong Li,Ben-Jie Shan,Lei Wang et al.
Mai-Dong Li et al.
Background: Breast cancer is characterized as highly heterogenous and is a representative model to understand how molecular features of tumor biology determine therapeutic strategy. LINC01133 exhibits opposing expressing ...
The burden of breast cancer in Poland: current status and future directions [0.03%]
波兰乳腺癌疾病负担：现状及未来方向
Wojciech Sierocki,Ligia Kornowska,Alicja Dudek et al.
Wojciech Sierocki et al.
Breast cancer poses a significant public health challenge in Poland, with incidence rates exceeding the EU average and a concerning disparity between incidence and mortality. This review analyzes the key steps of breast cancer diagnosis and...