NK cell-related genes-driven novel molecular subtyping and prognostic signatures for Wilms tumor: uncovering the therapeutic potential of TGX-221 and biomarker role of HS2ST1 [0.03%]
基于NK细胞相关基因的儿童肾母细胞瘤分子分型及预后标志物研究：TGX-221药物治疗潜能及HS2ST1生物标记物作用机制探究
Peng Hong,Zaihong Hu,Jie Lin et al.
Peng Hong et al.
Background: Wilms tumor (WT) lacks precise molecular subtyping tools, which limits the development of personalized therapies. To address this issue, we investigated whether NK cell-related genes (NKGs) could refine the mo...
Lingshan Liao,Mengying Zeng,Debei Liu et al.
Lingshan Liao et al.
Gut microbes are emerging as critical regulators in cancer therapy, influencing the efficacy and toxicity of radiotherapy, chemotherapy, immunotherapy, targeted therapy, Traditional Chinese Medicine, and rehabilitation interventions. Acting...
Case Report: Tislelizumab-induced delayed-onset diabetic ketoacidosis and hypothyroidism in esophageal adenocarcinoma [0.03%]
病例报告：替雷利珠单抗诱导的晚期糖尿病酮症酸中毒和甲状腺功能减退（食管腺癌）
Zhaoyang Li,Kangning Han,Li Li et al.
Zhaoyang Li et al.
Immune checkpoint inhibitor-related diabetes ketoacidosis (ICI-DKA) and hypothyroidism are rare but serious adverse events of Anti-programmed cell death-1 (anti-PD-1) therapy, previously unreported in patients with EAC receiving tislelizuma...
Molecular and histopathological landscape of 131 meningiomas: a retrospective institutional study with insights from cIMPACT-NOW [0.03%]
基于cIMPACT-NOW的机构回顾性研究揭示了131例脑膜瘤的分子和组织病理特征
Rola H Ali,Abdulaziz Hassan,Hussain H Jarkhi et al.
Rola H Ali et al.
Background: Prognostication in meningiomas has traditionally relied on histopathological grading, which has inherent limitations, including interobserver variability, intratumoral heterogeneity, and inconsistent correlati...
Efficacy and liver function preservation with donafenib combined with transarterial chemoembolization in unresectable hepatocellular carcinoma: An ALBI grade analysis [0.03%]
评估多纳非尼联合TACE治疗不可切除肝细胞癌有效性和肝脏保护作用的ALBI分级分析
Jinpeng Li,Yan Li,Yuanming Li et al.
Jinpeng Li et al.
Purpose: This study evaluated the hepatoprotective effects and safety profile of donafenib combined with transarterial chemoembolization (TACE) in unresectable hepatocellular carcinoma (HCC) through analysis of albumin-bi...
Global research trends in radiotherapy for bone metastases: a systematic bibliometric analysis [0.03%]
骨转移放射治疗全球研究趋势的系统文献计量分析
Fadong Yin,Xuan Liu,Xianxiu Nan et al.
Fadong Yin et al.
Background: With the development of various advanced radiotherapy techniques, research related to radiotherapy for bone metastases has made great progress, and scholars have published a large number of publications. In th...
Risk factors and quality of life in adults with dysphagia after posterior skull base surgery: a cross-sectional study [0.03%]
吞咽困难成人后颅底手术的风险因素及生活质量：横断面研究
Qiao Wang,Shang-Jin Cheng,Dan Duan et al.
Qiao Wang et al.
Introduction: The study aimed to evaluate the current status of swallowing function and quality of life in patients undergoing posterior skull base surgery, identify risk factors for dysphagia, and provide evidence for ea...
Multi-omics modality completion and knowledge distillation for drug response prediction in cervical cancer [0.03%]
整合癌症多组学模态完成与知识蒸馏的药物响应预测方法研究宫颈癌样本案例
DongZi Li,Bowei Yan,Kai Liao et al.
DongZi Li et al.
In clinical practice, the development of personalized treatment strategies for cervical cancer is hindered by the limited accuracy of drug response prediction, partly due to missing modalities in multi-omics data. We present MKDR, a deep le...
The prognostic value of health-related quality of life for early molecular response in patients with chronic myeloid leukemia: analysis of the GIMEMA-SUSTRENIM trial [0.03%]
健康相关生活质量对慢性髓性白血病患者早期分子反应的预测价值：GIMEMA-SUSTRENIM试验分析
Fabio Efficace,Laura Cannella,Isabella Capodanno et al.
Fabio Efficace et al.
We aimed to explore the prognostic value of patient-reported health-related quality of life (HRQoL) data for the achievement of early molecular response (EMR) at 3 months in patients with chronic phase chronic myeloid leukemia (CP-CML). We ...
Therapeutic potential of TRIM family proteins in gastric cancer: from signaling pathway regulation to precision targeting strategies [0.03%]
TRIM家族蛋白在胃癌治疗中的潜力：从信号通路调控到精准靶向策略
Caiqing Zhao,Jialing Qi,Zhenze Zhang et al.
Caiqing Zhao et al.
Gastric cancer (GC) is a globally prevalent malignant tumor, causing approximately 770,000 deaths in 2020, ranking fourth among all cancers. The tripartite motif (TRIM) protein family is involved in various cellular regulations and has beco...