Combination of BRCA deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer [0.03%]
卵巢癌同源重组缺陷的检测-基于BRCA深度靶向测序和全基因组浅层测序相结合的方法学研究
Thien-Phuc Nguyen Hoang,Nam H B Tran,Tien Anh Nguyen et al.
Thien-Phuc Nguyen Hoang et al.
Backgrounds: Assessing homologous recombination deficiency (HRD) has been recommended by clinical guidelines for patients with ovarian cancer (OC) as it predicts sensitivity to poly (ADP-ribose) polymerase inhibitors (PAR...
Case report of misdiagnosis: a rare case of hepatic epithelioid hemangioendothelioma characterized primarily by fever [0.03%]
误诊病例报告：以发热为主要表现的肝上皮样血管内皮细胞瘤1例
Jian Zhao,Yanli Dang
Jian Zhao
This study reports a case of a 47-year-old female who was initially misdiagnosed as having liver abscess due to repeated fever, and was later misdiagnosed again as liver inflammatory myofibroblastic tumor(IMT) after liver biopsy. After surg...
MEX3A is a diagnostic, independent prognostic biomarker and a promising therapeutic target in glioblastoma [0.03%]
MEX3A是胶质母细胞瘤的诊断和独立预后生物标志物以及有希望的治疗靶点
Francesca Bufalieri,Daniele Armocida,Antonino Cucinotta et al.
Francesca Bufalieri et al.
Objective: Gliomas are the most common malignant brain tumors with a poor prognosis. Despite advances in molecular profiling, no targeted therapies significantly improve survival. Recently, it has been demonstrated that h...
Are brain metastases a special issue in POLE-mutated endometrial cancer? a case report series [0.03%]
POLE突变型子宫内膜癌脑转移一例报告系列
Christoph Ebner,Kristina Lindemann,Gunnar Kristensen et al.
Christoph Ebner et al.
POLE-mutated endometrial cancers have repeatedly shown to harbor an excellent prognosis. Recurrences or primary advanced disease are rare events in this subgroup. We report three cases of POLE-mutated endometrioid ECs with brain metastases....
Evaluation of anti-liver cancer activity and anticancer mechanism of one novel small molecule compound (THY-10A62) targeting FAK pathway [0.03%]
一种针对FAK途径的新型小分子化合物(THY-10A62)的抗肝癌活性及抗癌机制评价
Wanqiu Huang,Rong Zou,Jie Xu et al.
Wanqiu Huang et al.
Introduction: Focal adhesion kinase (FAK) is a promising therapeutic target, and its aberrant overexpression has been implicated in the growth and metastasis of multiple cancers, including hepatocellular carcinoma (HCC). ...
Application of machine learning for prognostic modeling in unresectable pancreatic cancer treated with chemoradiotherapy [0.03%]
人工智能在不可切除胰腺癌同步放化疗预后模型中的应用研究
Wei Xiao,Binbin Yang,Shanbao Ke
Wei Xiao
Background: Patients with unresectable pancreatic cancer have poor outcomes despite chemoradiotherapy (CRT). Traditional prognostic tools lack accuracy in predicting survival. This study aimed to develop an artificial int...
Diaryl pyrimidine guanidine suppresses hepatocellular carcinoma cell stemness by targeting β-catenin signaling [0.03%]
二芳基嘧啶胍通过靶向β-连环蛋白信号抑制肝癌细胞干性
Xuechun Chen,Dongxuan Ni,Jinghui Cheng et al.
Xuechun Chen et al.
Background: Liver cancer remains a major global health burden, with hepatocellular carcinoma (HCC) accounting for approximately 80% of liver cancer cases. Cancer stem cells (CSCs) play a critical role in HCC initiation, p...
Case Report: Acute kidney injury due to minimal dilated obstructive nephropathy in the context of gastric cancer [0.03%]
个例报告：胃癌合并肾小管囊肿的急性肾损伤病例报告
Xinyu Xiang,Xiaobao Wei,Jiayi Miao et al.
Xinyu Xiang et al.
Postrenal obstruction is a rare but reversible cause of acute kidney injury (AKI), often underrecognized when hydronephrosis is mild or absent. We present a 55-year-old woman with gastric cancer who developed severe AKI requiring hemodialys...
The application of peripheral blood immune profiling in personalized treatment of locally advanced and advanced lung cancer: a nomogram approach [0.03%]
基于外周血免疫谱的晚期肺腺癌个体化治疗及预后评估体系的建立及临床应用研究
Tianwen Yin,Yikun Li,Qixin Sun et al.
Tianwen Yin et al.
Purpose: Immunotherapy has revolutionized the treatment of lung cancer, yet many patients experience limited or transient benefits. Identifying those most likely to benefit remains a critical challenge. This study aims to...
Advances in reproductive management strategies for thyroid cancer patients during the perinatal period: a narrative review [0.03%]
甲状腺癌患者围产期生殖管理策略的研究进展：综述性文章
Ying Dong,Juxiang Gou
Ying Dong
Changes in thyroid function during the perinatal period significantly impact patients' fertility, necessitating targeted adjustments in management strategies to ensure hormone stability while weighing the effects of treatment on both the mo...