Osthole suppresses prostate cancer progression by modulating PRLR and the JAK2/STAT3 signaling axis [0.03%]
Osthol通过调节PRLR和JAK2/STAT3信号轴抑制前列腺癌进展
Linjun Yan,Jiaqi Mei,Yuanqiao He et al.
Linjun Yan et al.
Background: Prostate cancer is a common malignancy in men with limited effective treatment options, highlighting an urgent need for novel therapeutic approaches. Osthole, a natural coumarin compound with antitumor propert...
Case Report: Tumor lysis syndrome in advanced, massive hepatocellular carcinoma with main portal vein invasion following atezolizumab plus bevacizumab therapy [0.03%]
个例报告：阿特朱单抗联合贝伐珠单抗治疗进展期大肝癌合并主瘤静脉侵犯后出现肿瘤溶解综合征
Tien-Shin Chou,Chun-Feng Wu,Chih-Lang Lin et al.
Tien-Shin Chou et al.
Background: Tumor lysis syndrome (TLS) is extraordinarily rare in solid tumors. However, the combination of atezolizumab and bevacizumab (AB) in advanced hepatocellular carcinoma (HCC) has raised concerns for abrupt metab...
Better performance of cerebral blood volume images synthesized from arterial spin labeling and standard MRI in separating glioblastoma recurrence from treatment response than arterial spin labeling [0.03%]
基于动脉自旋标记和常规MRI合成脑血容量图在鉴别胶质母细胞瘤复发与治疗反应性改变中的优势
Danyang Wu,Yongsheng Pan,Yunxiao Zhou et al.
Danyang Wu et al.
Cerebral blood volume (CBV) maps play an important role in the differential diagnosis between glioblastoma recurrence and treatment response. However, it needs high injective velocity. This study aimed to synthesize CBV maps from arterial s...
Identification and comprehensive analysis of an immune-related gene prognostic model for indicating tumor immune microenvironment features in soft tissue sarcoma [0.03%]
鉴定并综合分析软组织肉瘤免疫相关基因预后模型以表征肿瘤免疫微环境特征
Shizhao Xu,Yuqiang Liu,Qian Cai et al.
Shizhao Xu et al.
Background: the STS is a rare type of tumor, and although its treatment has improved greatly in recent decades, the treatment of STS and the development of new drugs remains a major challenge. A new identification of prog...
Functional outcomes and quality of life following free fibula flap harvest: a comparative analysis of flexor hallucis longus resection versus preservation [0.03%]
腓肠神经营养皮瓣切取时保存屈拇长伸肌和切除屈拇长伸肌的临床疗效及生活质量比较研究
Guanghui Zhao,Xu Zhang,Wei Du et al.
Guanghui Zhao et al.
Background: The free fibula flap (FFF) is a gold standard for maxillofacial reconstruction, yet debate persists regarding the functional impact of flexor hallucis longus (FHL) resection. This study evaluates donor-site mo...
Development and validation of multiparameter prognostic nomogram combining neutrophil-to-lymphocyte ratio, tumor burden, and nutritional status for predicting postoperative outcome in elderly gastric cancer patients [0.03%]
结合中性粒细胞与淋巴细胞比率、肿瘤负荷和营养状况预测老年胃癌患者术后预后的多参数预后预测列线图的构建及验证
Dongyuan Liu,Yan Jiang,Min Gao
Dongyuan Liu
Objective: This study aims to construct and verify Nomogram prediction model for clinical outcomes of elderly patients with gastric cancer after surgery, which is based on multiple factors such as peripheral blood neutrop...
Oleanolic acid alleviates ovarian cancer by regulating the miR-122/PDK4 axis to induce autophagy and inhibit glycolysis in vivo and in vitro [0.03%]
牛磺酸通过调节miR-122/PDK4轴诱导自噬并抑制糖酵osis来缓解卵巢癌
Zhen Zeng,Qing Lin,Jing Yu et al.
Zhen Zeng et al.
Background: Ovarian cancer (OC) is a gynecological tumor with a high incidence and poor prognosis. Oleanolic acid (OA) plays a crucial role in cancers with its anti-cancer function. The study aimed to identify the effects...
Dandan Li,Xu Lei,Lanlan Zhao et al.
Dandan Li et al.
High mobility group protein 1 (HMGB1) is a highly conserved chromatin-associated protein that is widely found in eukaryotic cells. Studies have shown that HMGB1 plays an important role in the development and progression of urological malign...
Incremental diagnostic value of tumor habitat radiomics for risk stratification in thymic epithelial tumors [0.03%]
基于肿瘤微环境的影像组学技术在纵隔肿瘤风险分层中的 incremental 诊断价值研究
Yiqiao Wang,Zhe Shi,Qinliang Sun et al.
Yiqiao Wang et al.
Purpose: To determine the incremental diagnostic value of habitat radiomics for risk stratification of thymic epithelial tumors (TETs) based on contrast-enhanced CT (CECT). ...
Research on the function of GPX4 in tumor-targeted treatment based on its molecular structure and features [0.03%]
基于GPX4分子结构与功能特征的肿瘤靶向治疗研究
He Geng,Lin Ma,Lixin Wu et al.
He Geng et al.
GPX4 is the only antioxidant enzyme in mammals that can convert cholesterol and phospholipid hydroperoxide into phosphatidylol and cholesterol. Its peculiar molecular structure allows it to perform a variety of biological functions, includi...