Efficacy and safety of anlotinib for the treatment of advanced bone and soft tissue sarcomas: a systematic review and meta-analysis [0.03%]
阿诺芦定治疗晚期骨及软组织肉瘤有效性和安全性的系统评价和meta分析
Zhipeng Li,Peng Fang,Shiwen Shen et al.
Zhipeng Li et al.
Background: Sarcoma, a rare and highly heterogeneous malignant neoplasm originating from mesenchymal tissues, is broadly classified into bone sarcoma and soft tissue sarcoma depending on where they occur. Patients with ad...
M1 macrophage-derived exosomal miR-20b promotes radiosensitization via CCND1 in HPV+ HNSCC [0.03%]
M1型巨噬细胞源性外泌体miR-20b通过CCND1促进HPV阳性HNSCC放射增敏作用
Huan Liu,Siwei Zhang,Zengchen Liu et al.
Huan Liu et al.
Background: Human papillomavirus (HPV) is a significant risk factor for head and neck squamous cell carcinoma (HNSCC). HPV positive (HPV+) HNSCC is more sensitive to radiotherapy and has a better prognosis than HPV negati...
Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways [0.03%]
病例报告：染色质重塑和DNA损伤修复通路共突变的SMARCA4缺陷型NSCLC脑转移癌
Jiaqin Song,Shikun Yang,Lei Xia
Jiaqin Song
SMARCA4 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) is the core ATPase subunit of SWI/SNF chromatin remodeling complexes. Its deficiency constitutes a rare and aggressive subtype of non-sm...
Margret Jensdottir,Ole Solheim,Alba Corell et al.
Margret Jensdottir et al.
Background and objectives: Maximal safe resection is the cornerstone of diffuse low-grade glioma (dLGG) management, although epidemiological data are limited. We aim to explore surgical selection, techniques, and outcomes...
Tumor-associated macrophage expression in colorectal adenomas and carcinomas: relationship to Helicobacter pylori infection [0.03%]
肿瘤相关巨噬细胞在结肠直肠腺瘤和癌组织中的表达及其与幽门螺杆菌感染的关系
Wenming Wang,Yueyong Zhu,Yunchao Zhu et al.
Wenming Wang et al.
Objective: This study investigated the association between Helicobacter pylori (H. pylori) infection and the expression of CD163+ and CD86+ tumor-associated macrophages (TAMs) in colorectal adenoma (CRA) and colorectal ca...
The impact of BRCA mutation and hormone receptor status on the outcomes of fertility preservation in breast cancer patients: a systematic review and meta-analysis [0.03%]
BRCA基因突变和激素受体状态对乳腺癌患者生育力保护结局的影响：系统评价和 Meta 分析
Liyu Ye,Weihui Yang,Huiyuan Guan
Liyu Ye
Background: Fertility preservation is a critical aspect of care for young breast cancer (BC) patients undergoing gonadotoxic treatments. BRCA mutation and hormone receptor (HR) status influence tumor biology and treatment...
Stage-specific and regional trends in prostate cancer incidence in Kazakhstan, 2005-2024 [0.03%]
2005-2024年哈萨克斯坦前列腺癌发病率的阶段性及地区性趋势
Gulnur Igissinova,Nurbek Igissin,Indira Kudaibergenova et al.
Gulnur Igissinova et al.
Background: Prostate cancer is a leading malignancy among men globally and continues to be a growing concern in Kazakhstan, where evidence regarding its long-term epidemiological trends is limited. ...
Ultrasound-based comparative assessment of ipsilateral vs. contralateral axillary lymph nodes in breast cancer patients - a pilot study [0.03%]
乳腺癌患者同侧与对侧腋窝淋巴结超声对比研究——一项前瞻性研究
Nicoleta Zenovia Antone,Roxana Pintican,Bogdan Fetica et al.
Nicoleta Zenovia Antone et al.
Background: Accurate axillary lymph node assessment is critical in breast cancer staging. This study aimed to evaluate whether ultrasound (US)-based measurements, particularly cortical thickness and comparison with contra...
Gut microbiome alterations and their clinical and biological implications in ovarian cancer: a systematic review [0.03%]
卵巢癌患者肠道菌群的改变及其临床和生物学意义的系统评价研究
Beibei Zhang,Nur Fatin Nabilah Mohd Sahardi,Kah Teik Chew et al.
Beibei Zhang et al.
Background: Increasing evidence shows the that gut microbiome (GM) plays a crucial role in ovarian cancer (OC) progression, offering potential avenues for microbiome-based intervention strategies. However, research in thi...
Targeting endoplasmic reticulum stress-induced CLGN resensitizes hepatocellular carcinoma to apoptosis: paeonol synergistically enhances efficacy by dual inhibition of CLGN and NF-κB [0.03%]
靶向毛地黄glycoprotein诱导的抗凋亡通路CLGN可使对凋亡产生敏感的肝细胞癌再次对诱导凋亡产生反应：芍药苷通过抑制CLGN和NF-κB协同增强其有效性
Sitong Yan,Anqi Wang,Xiang Chen et al.
Sitong Yan et al.
Purpose: Endoplasmic reticulum stress (ERS) drives hepatocellular carcinoma (HCC) progression and therapy resistance. This study identifies Calmegin (CLGN) as a novel ERS-induced pro-survival factor and explores shCLGN co...