Case report: A challenging case of stage IVB mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder treated with extended radical resection including portal vein reconstruction [0.03%]
个案报告：一期切除联合肝门部静脉重建治疗胆囊混合神经内分泌肿瘤IVB期一例
Quanlei Wang,Shun Ruan,Xiyin Ye et al.
Quanlei Wang et al.
Background: Gallbladder cancer is a highly lethal biliary tract malignancy. Among them, mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN), particularly those containing large cell neuroendocrine carcinoma (LCNEC) ...
Radiogenomics and the DNA damage response: opportunities for biomarker-guided radiosensitization in pancreatic cancer [0.03%]
胰腺癌的放射增敏的辐射基因组学和DNA损伤修复：基于生物标志物指导放射增敏的机会
Marie Nour Karam,Joseph Hajj,Christopher H Crane et al.
Marie Nour Karam et al.
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis, despite significant research efforts. The use of radiotherapy (RT) in PDAC treatment is constrained by intrinsic PDAC radioresistance and concern for normal tissue t...
A multi-task deep learning framework for simultaneous prediction of microsatellite instability and tumor mutational burden in gastric cancer from histopathological images [0.03%]
一种用于同时预测胃癌组织病理图像中微卫星不稳定性及肿瘤突变负荷的多任务深度学习框架
Yazhou Chang,Haoyue Chang,Yaping Lv et al.
Yazhou Chang et al.
Background: The clinical management of gastric cancer (GC) increasingly relies on the biomarkers microsatellite instability (MSI) and tumor mutation burden (TMB) to identify patients likely to benefit from immunotherapy. ...
Digital Twins as catalysts for Whole Person Health Mind Body Medicine in Integrative Oncology [0.03%]
数字孪生在整合肿瘤学中的作用：身心医学与整体健康促进器
Claudia M Witt
Claudia M Witt
Artificial intelligence and digital health technologies are reshaping oncology through increasingly personalized, predictive, and data-driven care. Among these innovations, medical Digital Twins - dynamic virtual software representations of...
The gastrin-releasing peptide receptor in oncology: a comprehensive review of recent advances in targeted radionuclide theranostics [0.03%]
胃泌素释放肽受体在肿瘤学中的作用：靶向放射性同位素诊疗Recent进展的全面回顾
YunLong Yang,Jiang Fu,ShengJie Tang et al.
YunLong Yang et al.
The gastrin-releasing peptide receptor (GRPR) is aberrantly expressed in several malignancies, including prostate cancer, breast cancer, lung cancer, and gastrointestinal stromal tumors, making it an important target for molecular imaging a...
Kexin Geng,Feng Gao
Kexin Geng
Small cell carcinoma of the prostate is an uncommon malignancy with an aggressive clinical course. Its non-specific symptoms and frequently normal prostate-specific antigen (PSA) levels can make early diagnosis difficult. We report a 74-yea...
An exploratory integrative analysis of plasma transcriptomic and proteomic predictors of response to total neoadjuvant therapy in locally advanced rectal cancer [0.03%]
局部晚期直肠癌新辅助治疗疗效的血浆转录组和蛋白组预测因子的整合分析
Zonglin Zhu,Kaizhen Wen,Baoyi Zou et al.
Zonglin Zhu et al.
Background: LARC patients exhibit heterogeneity in their response to total neoadjuvant therapy (TNT). This study aims to screen and identify plasma biomarkers associated with treatment response to TNT in patients with loc...
Efficacy and safety of radiotherapy combined with chemoimmunotherapy versus chemoimmunotherapy alone as first-line treatment for metachronous oligorecurrent esophageal squamous cell carcinoma [0.03%]
放疗联合化疗免疫治疗与单纯化疗免疫治疗作为异时寡转移性食管鳞癌一线治疗的疗效和安全性：一项前瞻性、随机、对照、多中心的II期临床试验
Xiaoyan Lv,Yuan Wang,Jingyi Ai et al.
Xiaoyan Lv et al.
Purpose: Metachronous oligorecurrence is usually defined as oligometastatic disease diagnosed more than 6 months after primary tumor diagnosis in the absence of active systemic therapy. This study aimed to assess the safe...
A systematic review of immune checkpoint inhibitors in endometrial cancer [0.03%]
免疫检查点抑制剂治疗子宫内膜癌的系统评价研究进展
Na Zhu,Chaihong Zhang
Na Zhu
Background: Endometrial cancer represents one of the most prevalent gynecological malignancies. This study aims to systematically analyze the knowledge frameworks, key contributors, research hotspots, emerging trending to...
Lobectomy versus sublobar resection for stage I non-small cell lung cancer: an umbrella review of evidence quality, overlap, surgical-extent heterogeneity, and survival outcomes [0.03%]
肺叶切除术与亚肺叶切除术治疗Ⅰ期非小细胞肺癌的有效性、异质性和生存结果的伞式评价
Xiang Lin,Jingwen Zhang,Beinuo Wang et al.
Xiang Lin et al.
Background: Whether sublobectomy achieves survival outcomes comparable to lobectomy in Stage I non-small cell lung cancer (NSCLC) remains controversial. With increasing adoption of parenchymal-sparing surgery, a comprehen...