Assessment of subventricular zone irradiation in glioblastoma patients [0.03%]
评价胶质母细胞瘤患者的亚 ventricle 区域照射
Laya K Pillai,Maitrik J Mehta,Ankita Parikh et al.
Laya K Pillai et al.
Background: Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with near-universal recurrence despite multimodality treatment. Increasing evidence suggests that the subventricular zone (SVZ), a major...
Efficacy and safety of neoadjuvant therapies for high-risk and locally advanced prostate cancer in older adults: a systematic review and network meta-analysis [0.03%]
老年高危和局部晚期前列腺癌新辅助治疗的有效性和安全性：系统评价和网络meta分析
Wenling Yuan,Yu Wang,Qi Liu et al.
Wenling Yuan et al.
Background: Brief overview of high-risk/locally advanced prostate cancer in older adults, current neoadjuvant therapies (NHT, NNHT, NCHT), and the uncertainty regarding their comparative efficacy on pathological outcomes....
A meta-analysis on the effectiveness and safety of FOLFOX plus bevacizumab for colorectal cancer treatment [0.03%]
氟尿嘧啶联合奥沙利铂和贝伐单抗治疗结直肠癌疗效和安全性的meta分析
Weiyin Ma,Zhengming Song,Yuandong Zhu
Weiyin Ma
Objective: Colorectal cancer is a globally prevalent malignancy of the digestive system. This systematic review and meta-analysis was conducted to evaluate the safety and effectiveness of bevacizumab combined with the FOL...
Case Report: Pembrolizumab unmasks a capillary leak syndrome with chylothorax in early TNBC [0.03%]
个例报告：派姆单抗揭发出早期三阴性乳腺癌患者出现的低血容量综合征和乳糜胸
Naïla Benkalfate,Ghazi Hadjamara,Caroline Petorin et al.
Naïla Benkalfate et al.
Pembrolizumab has become standard of care in early-stage triple-negative breast cancer (TNBC), but its expanding use may induce rare adverse events involving vascular and lymphatic endothelium. Capillary leak syndrome (CLS) remains an excep...
Immune-excluded and immune-suppressive tumor microenvironments: mechanisms, spatial biomarkers, and therapeutic rewiring [0.03%]
免疫排除和免疫抑制肿瘤微环境：机制、空间生物标志物和治疗重构
Bo Wang,Haixin Ding,Yutong Li et al.
Bo Wang et al.
Background: Immune checkpoint inhibitors have improved outcomes in several malignancies, yet durable benefit remains limited in most solid tumors because many lesions exhibit immune-excluded or immune-suppressive tumor mi...
Delayed cerebral radiation necrosis after osteoradionecrosis of the skull base: a case report [0.03%]
颅底骨放射性坏死后的延迟性脑组织放疗坏死1例报告
Maria A Jacome,Nadia Khalil,Neena Viswanathan et al.
Maria A Jacome et al.
Delayed cerebral radiation necrosis (CRN) is a condition characterized by fibrinoid necrosis, blood-brain barrier disruption, and demyelination due to endothelial cell and oligodendrocyte injury as a result of radiation therapy. The present...
Androgen receptor reactivation in castration-resistant prostate cancer: mechanisms, epigenetic adaptation, and therapeutic vulnerabilities [0.03%]
雄激素受体在去势抵抗性前列腺癌中的重新激活：机制、表观遗传适应和治疗弱点
Juntao Guo,Ke Wu,Zheng Ma et al.
Juntao Guo et al.
Castration-resistant prostate cancer (CRPC) remains a difficult clinical problem, although androgen deprivation therapy and next-generation androgen receptor (AR) pathway inhibitors have greatly improved patient treatment. CRPC is not simpl...
Early toxicity prediction using longitudinal cone-beam CT delta-radiomics in HPV-positive oropharyngeal cancer [0.03%]
基于纵向CBCT影像的三角形特征预测人乳头瘤病毒阳性口咽癌患者早期毒性反应
Levent Sensoy,Benjamin J Rich,Stuart E Samuels et al.
Levent Sensoy et al.
Introduction: Long-term survival in human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has shifted clinical focus toward minimizing treatment-related toxicities, particularly dysphagia, whi...
Development of a nomogram for predicting anastomotic leakage after rectal cancer surgery incorporating inflammatory indices [0.03%]
结合炎症指标预测结直肠癌术后吻合口漏的列线图模型的建立与发展
Feihong Zhao,Dongjie Zheng,Weiqiang Zhang et al.
Feihong Zhao et al.
Objective: Anastomotic leakage (AL) is a common and serious complication after rectal cancer surgery, and there is still a lack of effective prediction tools. This study aimed to build a prediction model for AL after rect...
SF3B4 stabilizes SREBF1 via 3'UTR binding to drive hepatocellular carcinoma progression [0.03%]
通过与3' UTR结合稳定SREBF1来驱动肝细胞癌进展的SF3B4
Yuan Fang,Dan Wang,Lei Han et al.
Yuan Fang et al.
Background: Hepatocellular carcinoma (HCC) represents a leading cause of cancer-associated deaths worldwide, and its development is strongly associated with aberrant RNA processing and metabolic reprogramming. Splicing fa...