Dose-dependent tuning of HSP70-Beclin-1 by kaempferol governs autophagy and chemosensitivity [0.03%]
穿心莲内酯剂量依赖性调节HSP70-Beclin-1调控自噬和化学敏感性
Suqin Hu,Yanan Guo,Mingyan Li et al.
Suqin Hu et al.
Introduction: Autophagy can either support cell survival or promote cell death in response to therapeutic stress, yet the molecular switch that determines this directionality remains poorly defined. ...
Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series [0.03%]
肿瘤内TLR4激动剂治疗引发转移性平滑肌肉瘤特异性T细胞克隆扩增：系列病例报告
Jessica S Zhang,Juliana C K Ng,Pedro Hermida de Viveiros et al.
Jessica S Zhang et al.
Metastatic soft tissue sarcomas (STSs) are a heterogeneous group of rare mesenchymal tumors whose treatment options are limited. Our group has been interested in utilizing the synthetic toll-like receptor 4 (TLR4) agonist, glycopyranosyl li...
Simplified PADUA renal nephrometry system, an imaging features scoring system, predicts perioperative outcomes in partial nephrectomy: a meta-analysis [0.03%]
简化PADUA肾肿瘤影像评分系统可预测部分肾切除术的围手术期结局：一项荟萃分析
Zhiqiang Zeng,Xionglin Hu,Tao Zhou et al.
Zhiqiang Zeng et al.
Objective: Does the simplified PADUA renal (SPARE) nephrometry system predict perioperative outcomes after partial nephrectomy (PN)? Methods: ...
The predictive value of multi-phase contrast-enhanced MRI for pathological complete response after neoadjuvant chemoradiotherapy in rectal cancer [0.03%]
术前新辅助放化疗后多时相对比增强MRI预测直肠癌病理完全缓解的价值
Jingjing Xie,Kaihe Lin,Suying Wu et al.
Jingjing Xie et al.
Background: Accurate prediction of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) for rectal cancer is crucial for determining subsequent treatment strategies. Although studies have shown ...
First case report of hypouricemia associated with adjuvant imatinib therapy in a patient with small intestinal gastrointestinal stromal tumor [0.03%]
伊马替尼辅助治疗小肠间质瘤患者的低尿酸血症首次病例报告
Juan Bu,Yeledan Mahan,Reziwanguli Yuemaier et al.
Juan Bu et al.
Imatinib, a tyrosine kinase inhibitor, is primarily used for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors (GIST). The most common adverse events include peripheral edema, mild nausea, vomiting, diarrhea, mya...
Differential expression of immune activation markers in T cells from patients with multiple myeloma [0.03%]
多发性骨髓瘤患者T细胞中免疫活化标志物的差异表达
Jiaoya Lin,Xin Zhang,Yifei Zhao et al.
Jiaoya Lin et al.
Introduction: Multiple myeloma (MM) is the second most common hematological malignancy, characterized by the abnormal proliferation of malignant plasma cells leading to the classic CRAB symptoms. Despite advances in treat...
Targeted therapy combined with local consolidative surgery for oligometastatic stage IVA lung adenocarcinoma with CCDC6-RET fusion: a case report [0.03%]
靶向治疗联合局部巩固性手术治疗CCDC6-RET融合阳性的寡转移IV期肺腺癌1例报告
Faxian Gao,Yijun Fan,Qingchun Fan et al.
Faxian Gao et al.
Background: Precision therapy for non-small cell lung cancer (NSCLC) has expanded to include rare driver genes. RET fusion is a rare target in lung cancer, and data on targeted therapy combined with local consolidation su...
miR-17: from developmental regulatory hub to molecular engine driving tumourigenesis [0.03%]
MiR-17：从发育调控中心到驱动肿瘤发生的分子引擎
Min Zhang,Yu Rong Ma,Xuan Yu Chen et al.
Min Zhang et al.
MicroRNA-17(miR-17) is a prototypical oncogenic miRNA that plays a central driving role in the initiation and progression of various malignant tumours (MT), including lymphoma, lung cancer, colorectal cancer (CRC), and breast cancer (BC). I...
Editorial: Insights into gastrointestinal cancer metastasis from preclinical models [0.03%]
述评：前期模型在胃肠道癌症转移中的研究新见解
Bruna Costa,Alyssa Schledwitz,Jean-Pierre Raufman
Bruna Costa
The translational paradox of AI in hepatocellular carcinoma: from algorithmic over-engineering to real-world clinical utility [0.03%]
人工智能在肝细胞癌中的转化悖论：从算法过度工程到现实世界临床价值
Chen Li,Yuka Yanase,Ming-Quan Pang
Chen Li
Synthesizing recent literature from 2025 to 2026, this mini-review critically evaluates the methodological evolution of artificial intelligence (AI) in hepatocellular carcinoma (HCC) from static pattern recognition to mechanism-driven spati...