Efficacy and safety of first-line osimertinib monotherapy versus osimertinib plus platinum-based chemotherapy or amivantamab plus lazertinib in metastatic EGFR-mutated NSCLC: an indirect comparison [0.03%]
一线奥希替尼单药治疗与奥希替尼联合基于铂的化疗或安玛法单抗联拉泽替尼对比治疗转移性EGFR突变NSCLC的有效性和安全性：间接比较
Luna Del Bono,Andrea Ossato,Lorenzo Gasperoni et al.
Luna Del Bono et al.
Background: Osimertinib (Osi) has long represented the standard first-line treatment for metastatic EGFR-mutated non-small cell lung cancer. Recently, two randomized phase 3 trials demonstrated that osimertinib plus plati...
Case Report: Experience of a rare case of primary acute mast cell leukemia with FGFR1 gene rearrangement [0.03%]
个例报道：携带FGFR1基因重排的原发性急性mast细胞白血病罕见病例一例
Yalu Liu,Sheng Gao,Huizhen Du et al.
Yalu Liu et al.
Mast cell leukemia represents the most malignant subtype of systemic mastocytosis, characterized by a dire clinical prognosis. Currently, no standard treatment regimen exists, with allogeneic hematopoietic stem cell transplantation being th...
The prognostic value of peripheral blood inflammatory markers in patients with HER2-positive metastatic breast cancer treated with pyrotinib [0.03%]
吡咯替尼治疗HER2阳性转移性乳腺癌患者外周血炎症标志物的预后价值
Wenqi Zhou,Jing Wu,Peng Zhang et al.
Wenqi Zhou et al.
Background: Different peripheral blood markers have been reported to be involved in different stages of breast cancer development and metastasis. However, the association between NLR, LDH and prognosis of pyrotinib in HER...
Case Report: Immune checkpoint inhibitor plus chemotherapy benefited an elderly patient with non-small cell lung cancer following EGFR-TKI resistance [0.03%]
病例报告：免疫检查点抑制剂联合化疗使EGFR-TKI耐药的晚期肺腺癌老年患者获益
Zhiyu Liu,Chenchen Wei,Chongguo Zhang et al.
Zhiyu Liu et al.
Renal metastasis from non-small cell lung cancer (NSCLC) is uncommon. This report describes an elderly patient with EGFR-mutant NSCLC and high PD-L1 expression (TPS 70%). Following six months of targeted therapy, the renal lesion increased ...
A rare incidence of primary pulmonary undifferentiated pleomorphic sarcoma detected as an endobronchial mass and treated by bronchoscopic resection: a case report and literature review [0.03%]
支气管内源性肉瘤一例报告及文献复习
Wei Wei,Huimin Wu,Hancheng Wang et al.
Wei Wei et al.
Rationale: Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS) is a highly malignant tumor with extremely rare occurrence and is known for its distinct cellular pleomorphism. This tumor lacks specific different...
Navigating the diagnostic pitfalls of cystic and solid breast masses: a comparative case report of metaplastic carcinoma and benign lesions [0.03%]
囊性及实性乳腺肿物诊断的陷阱——浸润性代谢性癌与良性病变的比较病例报告
Wenjie Chu,Mengting Dong,Jiayu Sheng et al.
Wenjie Chu et al.
Background: Cystic and solid masses (CSMs) present a significant diagnostic challenge due to their heterogeneous internal architecture and a relatively high malignancy rate (23%-31%). Metaplastic breast carcinoma (MBC), a...
Clinicopathological features and survival outcomes of HPV-independent versus HPV-associated cervical adenocarcinoma: a Systematic Review and meta-analysis [0.03%]
基于HPV和不基于HPV的宫颈腺癌的临床病理特征及生存结果：系统性综述与meta分析
Dan Wu,Yun Li,Yuehua Lang et al.
Dan Wu et al.
Background: Human papillomavirus (HPV)-independent cervical adenocarcinoma is increasingly recognized as a biologically and clinically distinct entity from HPV-associated adenocarcinoma. We aimed to compare the clinicopat...
Multimodal data fusion: integrating PET/MRI and liquid biopsy for a holistic view of cancer biology [0.03%]
多模态数据融合：整合PET/MRI和液体活检以全面观察癌症生物学
Yuying Zhao,Bo Shen,Wei Luo et al.
Yuying Zhao et al.
The systemic complexity and spatiotemporal heterogeneity of cancer demand diagnostic strategies beyond single modalities. The integration of positron emission tomography/magnetic resonance imaging (PET/MRI) with liquid biopsy offers a revol...
Prediction of cervical stromal invasion using ultrasound radiomics: from conventional ultrasound to intelligent diagnosis [0.03%]
基于超声影像组学的宫颈间质浸润深度的预测研究：从常规超声到智能诊断
Xiaoli Peng,Qisen Zhu,Lu Zhao et al.
Xiaoli Peng et al.
Rationale and objectives: Accurate preoperative assessment of cervical stromal invasion (CSI) in endometrial cancer (EC) is crucial for surgical planning, but conventional imaging has limited diagnostic performance. This ...
Case Report: Primary sciatic leiomyosarcoma in a patient with neurofibromatosis type 1 [0.03%]
NF1患者原发坐骨神经平滑肌肉瘤一例报告
Longgang Chen,Meiling Xu,Kai Cheng et al.
Longgang Chen et al.
This case report discusses a rare occurrence of primary sciatic leiomyosarcoma in a patient with type 1 neurofibromatosis. The patient had a gradually enlarging lump in her right thigh, which was diagnosed as a leiomyosarcoma after surgery....