Downregulation of OPCML is associated with activation of AKT signaling and aggressive phenotypes in glioblastoma cells [0.03%]
OPCML下调与胶质母细胞瘤细胞中AKT信号激活和侵袭性表型相关
Zhixin Liu,Chunhua Xu,Wu Zhou et al.
Zhixin Liu et al.
Background: OPCML (opioid-binding protein/cell adhesion molecule-like), a glycosylphosphatidylinositol (GPI)-anchored IgLON adhesion molecule with brain-enriched expression, has tumor-suppressive roles in several epitheli...
Interleukin 1 family dysregulation in serum and peritoneal fluid of ovarian cancer patients - potential clinical implications [0.03%]
卵巢癌患者血清和腹水中白细胞介素1家族失调-潜在的临床意义
Sebastian Stępień,Marta Smycz-Kubańska,Maria-Laura Morawiec et al.
Sebastian Stępień et al.
In the pathomechanism of ovarian cancer development, an important role is attributed to the chronic inflammatory process. Still, despite numerous studies, it has not been fully elucidated how immune inflammatory processes influence the deve...
The CDK inhibitor Roscovitine enhances the therapeutic efficacy of anti-PD-1 in non-small cell lung cancer [0.03%]
CDK抑制剂Roscovitine可增强抗PD-1治疗非小细胞肺癌的疗效
C Marcela Diaz-Montero,Elise G Holvey-Bates,Patricia A Rayman et al.
C Marcela Diaz-Montero et al.
Immune checkpoint blockade (ICB) targeting the PD-1/PD-L1 axis has significantly improved outcomes in non-small cell lung cancer (NSCLC), yet many patients fail to respond. High PD-L1 expression, often predictive of response, paradoxically ...
Functional pancreatic neuroendocrine tumors predominantly presenting with hypercalcemia: a case report [0.03%]
以高钙血症为主要表现的功能性胰神经内分泌肿瘤1例报告
Jieting Duan,Yanping Zhu,Yan Wang et al.
Jieting Duan et al.
Functional pancreatic neuroendocrine tumors (F-PNETs) that secrete parathyroid hormone-related protein (PTHrP) and cause hypercalcemia are extremely rare. This report details a 10-year course of a patient with pancreatic neuroendocrine tumo...
Case report: Minimally invasive management of synchronous early-stage ascending colon adenocarcinoma and type 1 papillary renal cell carcinoma presenting with severe anemia: a rare Chinese case [0.03%]
病例报告：一例罕见的中国患者同时患有升结肠腺癌和I型乳头状肾细胞癌并伴有严重贫血的微创治疗案例
Jiahao Li,Kai Guo,Li Yi et al.
Jiahao Li et al.
Background: Ascending colon adenocarcinoma(ACA) synchronous with papillary renal cell carcinoma (pRCC) is extremely rare, with only sporadic cases reported in the literature around the world. The oncogenic mechanisms, ear...
Comprehensive management of chest wall recurrent HER2-positive breast cancer with Anlotinib and hypofractionated radiotherapy: a case report [0.03%]
阿诺替尼联合根治量放射治疗管理胸壁复发HER2阳性乳腺癌一例报告
Jing Xu,Qing Liu,Yue Yin et al.
Jing Xu et al.
HER2-positive breast cancer (BC) patients who have developed resistance to various systemic therapies face limited treatment alternatives. Literature on Anlotinib combined with hypofractionated radiotherapy (HFRT) for recurrent/metastatic H...
MiR-10a-5p suppresses hepatocellular carcinoma progression and microvascular invasion by targeting TFR1-STAT3-CD24 signaling axis [0.03%]
miR-10a-5p通过靶向TFR1-STAT3-CD24信号轴抑制肝癌进展和微血管侵犯
Yupeng Zhang,Di Lai,Ziyi Wang et al.
Yupeng Zhang et al.
Background: Preoperative CT features have demonstrated potential in predicting microvascular invasion (MVI) in hepatocellular carcinoma. These CT signs serve as indicators of tumor biological behavior. However, the molecu...
Radiotherapy is associated with improved survival in stage I-II gastric MALT lymphoma after failed or inadequate Helicobacter pylori eradication: a single-center retrospective study [0.03%]
幽门螺杆菌根除失败或不足的I至II期胃MALT淋巴瘤患者放疗可改善预后：一项单中心回顾性研究
Miao Li,Wenjie Wang,Chi Lu et al.
Miao Li et al.
Objective: To investigate the impact of different first-line anti-tumor therapies on survival outcomes in patients with stage I-II gastric MALT lymphoma who failed or did not receive anti-Helicobacter pylori (H. pylori) t...
Reconstituting the head and neck tumor microenvironment with air-liquid interface organoids [0.03%]
用空气液体界面器官体重构头颈部肿瘤微环境
Luxi Zheng,Wei Tang,Shuqi Guo et al.
Luxi Zheng et al.
Introduction: A patient-derived head and neck cancer organoid (HNCO) model that can reconstruct the tumor-immune microenvironment (TME) was established using air-liquid interface (ALI) culture technology. The Tumor-Infilt...
De novo small cell neuroendocrine carcinoma of the prostate with extremely elevated PSA and Gleason score 5 + 5: a case report [0.03%]
前列腺新发小细胞神经内分泌癌并极度升高PSA和Gleason评分5+5一例报告
Yiwen Tang,Yuyang Cai,Xiaofeng Jiang et al.
Yiwen Tang et al.
Objectives: The aims of this study were to report an exceptionally rare case of de novo small cell neuroendocrine carcinoma of the prostate (SCNEPC) presenting with unprecedented prostate-specific antigen (PSA) elevation ...