TACE combined with regorafenib with or without anti-PD-1 therapy for advanced HCC after targeted therapy failure: a multicenter real-world study [0.03%]
经导管动脉化疗栓塞联合瑞戈非尼联合或不联合抗PD-1治疗用于靶向治疗失败的晚期肝细胞癌患者的多中心真实世界研究
Yan Li,Hang Yuan,Quan-Jun Yao et al.
Yan Li et al.
Background and objectives: Patients with hepatocellular carcinoma (HCC) progressing after targeted therapy face limited treatment options and poor prognosis. Although regorafenib is an established second-line therapy, its...
Risk stratification by ultrasound and mammography for screen-detected non-palpable breast cancer in Chinese women [0.03%]
中国女性乳腺癌筛查检出的非触诊包块型乳腺癌的超声和钼靶X线风险分类结果分析
Ying Xu,Ru Yao,Yan Lin et al.
Ying Xu et al.
Background: Mammography (MG) and ultrasound (US) are currently the 'real-world' initial imaging tests for breast cancer in China. Previously, we demonstrated that US and MG detected non-palpable breast cancer (NPBC) had s...
CT-based deep learning for preoperative prediction of pathological grading of renal clear cell carcinoma [0.03%]
基于CT的深度学习在肾透明细胞癌病理分级术前预测中的应用研究
Zhenyu Cui,Tao Ma,Kun Liu et al.
Zhenyu Cui et al.
Objective: To construct a noninvasive preoperative prediction model for WHO/ISUP grading of renal clear cell carcinoma (ccRCC) using deep learning combined with four-phase CT images, and to evaluate its efficacy. ...
Tumor DNA from tumor in situ fluid was used to track evolution of glioma under first-line treatment [0.03%]
应用液体活检追踪胶质瘤一线治疗过程中肿瘤的演化过程
Jinliang Yu,Yushuai Gao,Jiubing Zhang et al.
Jinliang Yu et al.
Introduction: Few studies have tracked the genetic evolution of glioma recurrence in patients after surgery. We conducted a systematic review through an innovative sampling method, which made post-operative follow-up poss...
Hereditary spherocytosis concomitant with JAK2V617F-positive primary myelofibrosis: a case report [0.03%]
遗传性球形红细胞增多症合并JAK2V617F阳性原发性骨髓纤维化病例报告
Chi-E Qiu,Lei Lei,Guosong Jiang et al.
Chi-E Qiu et al.
Hereditary spherocytosis (HS) is a genetic hemolytic disorder primarily characterized by hemolytic anemia, jaundice, splenomegaly, and frequent complications, including cholelithiasis, accompanied by the presence of spherocytes in the perip...
Case Report: Malignant peritoneal mesothelioma with TFG-ROS1 fusion responds to crizotinib [0.03%]
恶性腹膜间皮瘤合并TFG-ROS1融合基因一例及克唑替尼治疗响应报告
Wei Ye,Peng Li,Cong Fu et al.
Wei Ye et al.
Background: Malignant peritoneal mesothelioma (MPM) is an exceptionally rare tumor type, and its molecular properties are poorly understood. In recent years, gene rearrangement has been found in a subset of MPMs. However,...
Acute obinutuzumab-induced thrombocytopenia in follicular lymphoma: case report and literature review [0.03%]
奥比妥珠单抗诱导的滤泡性淋巴瘤急性血小板减少：病例报告及文献回顾
Jieyi Zhou,Miaomiao Chen,Yi Zhang et al.
Jieyi Zhou et al.
Introduction: Obinutuzumab, a type II anti-CD20 monoclonal antibody used in the treatment of follicular lymphoma, is associated with a higher incidence of adverse events, including thrombocytopenia, compared to rituximab....
Integrating single-cell transcriptomics and whole-genome CRISPR CAS9 screen identifies a cell cluster associated with tumor dependency in triple-negative breast cancer [0.03%]
单细胞转录组学与全基因组CRISPR筛选结合鉴定三阴性乳腺癌中肿瘤依赖相关细胞群
Su Liu,Shuo Wang,Guixin Wang et al.
Su Liu et al.
Background: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype; however, clinically approved prognostic biomarkers and therapeutic options remain limited. This study aimed to investigate tum...
Investigating subregional PD-L1 expression within primary tumors to predict clinical outcomes in advanced NSCLC patients who received ICB-based therapy [0.03%]
检测原发肿瘤内的PD-L1亚区域表达以预测晚期非小细胞肺癌患者接受基于ICB的治疗的临床结局
Danhong Zhou,Ziwen Zhu,Jingyu Mao et al.
Danhong Zhou et al.
Background: Programmed cell death-ligand 1 (PD-L1) immunohistochemical expression currently is the only approved useful biomarker associated with the PD-1/PD-L1 immune checkpoint blockade (ICB) efficacy for non-small cell...
Case Report: Complete pathologic response in advanced melanoma with SFRT and dual checkpoint inhibition [0.03%]
病例报告：单用立体定向放射治疗和双检查点抑制的晚期黑色素瘤获得完全病理缓解
Jared Hobson,Michael P Grams,Joanina K Gicobi et al.
Jared Hobson et al.
Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for advanced melanoma, though response rates remain limited in bulky disease. Herein, we report the case of a complete pathologic response following combination sp...