Real-world treatment patterns and clinical outcomes among elderly patients with locoregionally advanced head and neck squamous cell carcinoma in the United States [0.03%]
美国老年人局部区域晚期头颈鳞状细胞癌的治疗模式和临床结局研究
Dandan Zheng,Su Zhang,Behzad Bidadi et al.
Dandan Zheng et al.
Introduction: Multimodal therapy, including resection followed by adjuvant radiotherapy (RT) ± systemic therapy (ST) or definitive RT ± ST, is typically recommended for patients with locoregionally advanced head and nec...
Comprehensive prognostic model for immunotherapy in small cell lung cancer: a multi-center study integrating clinical and blood biomarkers [0.03%]
基于临床和血液生物标志物的广泛小细胞肺癌免疫治疗预后模型：一项多中心研究
Qiuqiao Mu,Yuhao Jing,Yun Ding et al.
Qiuqiao Mu et al.
Background: Small cell lung cancer (SCLC) is a highly aggressive and rapidly progressing form of lung cancer that is difficult to treat. Immunotherapy has provided encouraging outcomes, but only a small proportion of pati...
Archimedes navigation system-guided bronchoscopic trans-parenchymal nodule access for peripheral lung nodules: a single-center experience [0.03%]
一种新型导航系统（Archimedes）引导下的经肺实体瘤抵达针技术（TPNA）的单中心经验
Ping-Tsung Yu,Sheng Hsiung Yang,Hui-Hsuan Shih et al.
Ping-Tsung Yu et al.
Background: Peripheral pulmonary lesions (PPLs) present diagnostic challenges because of their small size and distal airway location, often requiring invasive surgical biopsies. The Archimedes™ navigation system assists ...
Impact of cervical osteoarthritis on quality of life after free flap reconstruction in head and neck cancer [0.03%]
颈部骨关节炎对头颈肿瘤游离皮瓣术后生活质量的影响
Yili Li,Wei Du,Xu Zhang et al.
Yili Li et al.
Background: Head and neck squamous cell carcinoma (HNSCC) often requires free flap reconstruction, which involves extensive cervical manipulation. Concurrently, cervical osteoarthritis is increasingly prevalent due to mod...
FLASH-RT for pulmonary protection: a comprehensive review of mechanisms, technological advances, and clinical translation [0.03%]
一种新的放射技术保护肺的机制、技术进展及临床应用综合述评——FLASH-RT
Yixue Wen,Xinlan Liu,Xiaohong Zhang et al.
Yixue Wen et al.
FLASH radiotherapy (FLASH-RT), characterized by ultra-high dose rates (>40 Gy/s), has demonstrated remarkable normal tissue-sparing effects in preclinical models while maintaining tumor control. This review specifically focuses on FLASH-med...
NEK4 suppresses cell proliferation in BT20 triple-negative breast cancer cells by diminishing expression of cell cycle genes, while its depletion mitigates proliferation in other cell lines [0.03%]
NEK4通过减少细胞周期基因的表达来抑制BT20三阴性乳腺癌细胞的增殖，而其耗竭则会减轻其他细胞系中的增殖现象
Rashmi R Joshi,E Gloria Sepulveda,F Ester Lujan et al.
Rashmi R Joshi et al.
Never In Mitosis Gene A (NIMA)-related kinase 4 (NEK4), a serine/threonine protein kinase, is involved in several cellular processes, including the DNA damage response and mRNA splicing, and we identified it as a potential new drug target i...
Hongyi Liang,Guangxi Shi,Hanhan Chen et al.
Hongyi Liang et al.
Granulomatous lobular mastitis (GLM) is a rare inflammatory breast disease, and there are few reports of GLM in pregnancy (GLMIP). Therefore, this study retrospectively analyzed cases diagnosed with GLMIP from 2011 to 2023 and found that in...
Anti-oxidative stress therapies prevent severe chemotherapy-induced peripheral neuropathy in colorectal cancer patients treated with oxaliplatin: a systematic review and meta-analysis [0.03%]
抗氧化应激疗法可预防奥沙利铂治疗结直肠癌患者引起的重度化疗性外周神经病变：一项系统评价和meta分析
Mohamed Salama,David Barnes,Anni Georghiou et al.
Mohamed Salama et al.
Background and purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side-effect of many commonly used cancer drugs, affecting up to 90% of patients treated with oxaliplatin. This systematic review and met...
The impact of perineural invasion on prognosis in esophageal cancer patients after surgery: a systematic review and meta-analysis [0.03%]
有关术前新辅助治疗的食管癌患者神经周围侵犯对预后影响的系统评价和 Meta 分析
Jicheng Xiong,Shuoming Liang,Simiao Lu et al.
Jicheng Xiong et al.
Objective: This study aims to update the prognostic value of perineural invasion(PNI) in various subgroups of esophageal cancer patients. Methods: ...
CCDC58 drives lung adenocarcinoma progression via the PI3K/AKT signaling pathway [0.03%]
CCDC58通过PI3K / AKT信号传导途径驱动肺腺癌进展
Wenchao Dai,Jun Yang,Wenming Yang et al.
Wenchao Dai et al.
Background: Previous studies have implicated Coiled-coil domain-containing 58 (CCDC58) in the malignant progression of hepatocellular carcinoma and breast cancer. However, its role in lung adenocarcinoma (LUAD) remains po...