Follow-up of hereditary endometrial carcinoma caused by MLH3 gene mutation: a case report [0.03%]
MLH3基因突变所致遗传性子宫内膜癌的随访观察1例报告
Changlin Zhang,Jiaying Ye,Qiaqia Li et al.
Changlin Zhang et al.
Background: Endometrial cancer is a common cancer in women, partially linked to defects in mismatch repair function. Besides the well-known mismatch repair proteins, the MLH3 gene may also contribute to cancer susceptibil...
Rational design of allosteric inhibitors targeting C797S mutant EGFR in NSCLC: an integrative in silico and in-vitro study [0.03%]
基于整合的计算和实验研究合理设计异构抑制剂靶向NSCLC中EGFR C797S突变体
Jian Wang,Feiyang Yuan,Mahadevi Kendre et al.
Jian Wang et al.
Background: The emergence of the C797S mutation in the epidermal growth factor receptor (EGFR) significantly limits the efficacy of covalent inhibitors in treating non-small cell lung cancer (NSCLC). This study aimed to d...
Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review [0.03%]
纳米颗粒介导的植物衍生成分在癌症治疗中的递送以调节免疫衰老引起的药物耐药性：综述型研究
Lichang Yang,Wei Wu,Jing Yang et al.
Lichang Yang et al.
Immunosenescence, the age-associated decline of the immune system, is pivotal in fostering drug resistance within the tumor microenvironment (TME). The accumulation of senescent immune cells and the release of pro-inflammatory senescence-as...
Iodine-125 seeds combined with anlotinib in the treatment of recurrent retroperitoneal liposarcoma after surgery: a case report [0.03%]
结合碘-125粒子与阿帕替尼治疗术后复发性后腹膜脂肪肉瘤1例报告
Gaoyan Tang,Yuping Zhang,Wenjuan Meng et al.
Gaoyan Tang et al.
Retroperitoneal liposarcoma (RPLS) is a rare malignant mesenchymal tumor originating in the retroperitoneal space. It is characterized by a low incidence, poorly understood etiology and pathogenesis, and diverse imaging and pathological man...
Development and validation of a prognostic model for patients with cT1-4N1-3M1 esophageal squamous cell carcinoma: based on the SEER database and the Chinese cohort study [0.03%]
基于SEER数据库和中国队列研究的cT1-4N1-3M1期食管鳞癌预后模型的建立与验证
Xiao-Mei Wang,Can-Tong Liu,Jia-Tao Huang et al.
Xiao-Mei Wang et al.
Objective: The purpose of this study was to investigate the impact of clinicopathological factors on the overall survival (OS) of advanced esophageal squamous cell carcinoma (ESCC) patients with both lymph node and distan...
Deciphering ERR family genes as prognostic and immunological biomarkers through pan-cancer analysis with validation in gallbladder cancer [0.03%]
基于泛癌分析并通过胆囊癌样本验证解读ERR家族基因的预后及免疫标志物价值
Wanwan Gong,Sijia Wen,Yu Chen et al.
Wanwan Gong et al.
Background: The estrogen-related receptor family genes (ERRs), including ESRRA, ESRRB, and ESRRG, have been implicated in a few tumors, exhibiting distinct roles through diverse mechanisms. The purpose of our research is ...
Calcifying fibrous tumor of stomach: a rare case report of an upper gastrointestinal bleeding [0.03%]
胃钙化性纤维瘤一例及文献复习
BaoLong Ye,ZiWen Chen,JunFeng Xie et al.
BaoLong Ye et al.
Introduction: Calcifying fibrous tumor (CFT) is an uncommon benign fibrous neoplastic lesion that may manifest as singular or multiple tumors and usually occurs in children or young adults. CFT originates in the musculari...
Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications [0.03%]
表观遗传学视角下的前列腺癌研究——组蛋白修饰及其治疗意义探索
Bunty Sharma,Himanshu Shekhar,Anidrisha Sahu et al.
Bunty Sharma et al.
Prostate cancer is one of the most prevalent malignancies globally. This cancerous condition originates within the prostate gland, an integral part of the male reproductive system. The molecular mechanism underlying cancer is among the key ...
Mechanisms of the JNK/p38 MAPK signaling pathway in drug resistance in ovarian cancer [0.03%]
JNK/p38MAPK信号转导通路在卵巢癌耐药中的机制研究
Yu-Ting Ma,Chan Li,Ying Shen et al.
Yu-Ting Ma et al.
Ovarian cancer (OC) is the most lethal malignancy in the female reproductive system, and chemotherapy drug resistance is the main cause of treatment failure. The Mitogen-Activated Protein Kinases (MAPK) pathway plays a pivotal role in regul...
Recent advances in therapeutic use of transforming growth factor-beta inhibitors in cancer and fibrosis [0.03%]
转化生长因子-β抑制剂在癌症和纤维化治疗中的最新进展
Hanhui Jing,Yan Gao,Linyuan Jing et al.
Hanhui Jing et al.
Transforming growth factor-beta (TGF-β) has long been known to be associated with early embryonic development and organogenesis, immune supervision, and tissue repair and homeostasis in adults. TGF-β has complex roles in fibrosis and canc...