Real-world efficacy and safety of PD-1 inhibitors in patients with advanced esophageal squamous cell carcinoma: a single-center retrospective analysis [0.03%]
抗PD-1抑制剂治疗晚期食管鳞癌真实世界疗效和安全性研究：一项单中心回顾性分析
Xin Wang,Lili Jia,Yijian Zhao et al.
Xin Wang et al.
Background: Esophageal squamous cell carcinoma (ESCC) is associated with high mortality and limited treatment options. While PD-1/PD-L1-targeted immunotherapy has shown promise, clinical trial results may not fully repres...
3D-printed PEEK versus conventional free fibula flap for jaw reconstruction: a comparative clinical study [0.03%]
基于3D打印的peek材料与常规游离腓骨肌皮瓣下颌重建术的临床比较研究
Dongdong Feng,Yuxiang Zhang,Haiwei Guo et al.
Dongdong Feng et al.
Purpose: Aimed to evaluate the application value of polyether ether ketone (PEEK) based on three-dimensional (3D) printing technology for jaw reconstruction. ...
High BMI-attributable female-specific cancers: a comprehensive analysis of the global disease burden and trends from 1990 to 2021 and projections to 2040 [0.03%]
高体重指数（BMI）相关女性特有癌症的全球疾病负担及趋势：1990至2021年的全面分析以及2040年预测
Guangming Sun,Junmei Tang,Hao Chen et al.
Guangming Sun et al.
Background: High body mass index (BMI) is a key modifiable risk factor for breast, ovarian, and uterine cancer. Despite the ongoing global obesity epidemic, a systematic assessment of the long-term burden trends and dispa...
Use of imiquimod topical therapy for management of malignant melanoma positive margins [0.03%]
咪喹莫德外用治疗恶性黑色素瘤阳性切缘的观察研究
Katelyn Lewis,Sara Islam,David P Alper et al.
Katelyn Lewis et al.
Introduction: The treatment of positive margins following primary resection of cutaneous melanoma remains controversial with the current standard of care being repeat surgical resection. 5% topical imiquimod therapy has b...
Navigating the risks: a systematic review of immune checkpoint inhibitor therapy before liver transplant for hepatocellular carcinoma and its impact on allograft rejection and survival outcomes [0.03%]
免疫检查点抑制剂在肝癌患者肝脏移植术前的应用及其对移植物排斥和生存率影响的系统性回顾分析
Donghua Liu,Xinyi Wang,Xuelian Liu et al.
Donghua Liu et al.
Background: The administration of immune checkpoint inhibitors (ICIs) prior to liver transplantation (LT) for hepatocellular carcinoma (HCC) has been reported. Several studies suggest that ICIs may elevate the risk of all...
Progress of long-chain noncoding small nucleolar RNA host genes in thyroid cancer [0.03%]
长链非编码小核仁RNA宿主基因在甲状腺癌中的进展研究
Tingyu Yang,Yuanxu Xie
Tingyu Yang
Small nucleolar RNA host genes (SNHGs) are a class of long non-coding RNAs that are widely aberrantly expressed in thyroid cancer and regulate tumor progression through the "SNHG-miRNA-signaling pathway" network. SNHG7 promotes cell prolife...
Prognostic impact of CT-derived muscle-adipose index change in patients with inoperable esophageal squamous cell carcinoma undergoing chemoradiotherapy [0.03%]
基于CT的肌肉-脂肪指数变化对不可手术食管鳞癌患者同期放化疗预后的影响研究
Bingyi Zhang,Dong Guo,Yuanyuan Cai et al.
Bingyi Zhang et al.
Background: The muscle-adipose index (MAI), a novel nutritional parameter for assessing body composition, has emerged as a potential prognostic indicator. This study aimed to research MAI and its longitudinal changes befo...
Antibody-drug conjugate: a newly developed biological missile for tumor treatment [0.03%]
抗体药物偶联物：肿瘤治疗的新型生物导弹
Zhuoran Tang,Yanchun Xie,Yanping Zeng
Zhuoran Tang
Antibody-drug conjugates (ADCs) represent one of the most advanced drug configurations under current research, primarily composed of a monoclonal antibody (mAb), a highly potent cytotoxic payload, and a linker that connects the drug to the ...
Case Report: Two cases of long-term survival in advanced pancreatic cancer patients following treatment with KRAS G12C inhibitors [0.03%]
病例报告：KRAS G12C抑制剂治疗晚期胰腺癌患者的长期生存案例分析
Saeed Aslani,Owen McKay,Lara Lipton et al.
Saeed Aslani et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a dismal prognosis. Molecular profiling to improve the diagnosis and management of PDAC holds promise for informing more targeted therapies such as Kirsten rat s...
Long-term survival following multimodal therapy for lung cancer with hepatic metastasis: a case report [0.03%]
多模式疗法治疗肝转移性肺癌的长期存活：一例报告
Zhao Junjun,Zhang Jiandong,Dong Lingjun et al.
Zhao Junjun et al.
Background: The liver serves as a predominant metastatic site in advanced lung cancer, with patients developing hepatic metastases demonstrating particularly dismal prognosis and a median survival of approximately 5 month...