Machine learning assisted breathomic approach for early-stage thoracic cancer detection [0.03%]
机器学习辅助的呼吸组学方法在肺癌早期诊断中的应用
Zhenguang Chen,Minhua Peng,Pengnan Fan et al.
Zhenguang Chen et al.
Objective: This study explores the feasibility of using breathomic biomarkers analyzed by machine learning as a non-invasive diagnostic tool to differentiate between benign and malignant thoracic lesions, aiming to enhanc...
Role and prognostic value of oncostatin M and its receptor OSMR in acute myeloid leukemia, myeloproliferative neoplasms and non-hematological malignancies [0.03%]
Oncostatin M及其受体OSMR在急性髓系白血病、髓系肿瘤和非血液系统恶性肿瘤中的作用及预后价值
Jean-Pierre Lévesque,Kavita Bisht,Kylie A Alexander et al.
Jean-Pierre Lévesque et al.
The oncostatin M receptor (OSMR) has recently emerged as an adverse prognostic factor in acute myeloid leukemia (AML) and several non-hematological malignancies. In this perspective, we discuss how oncostatin M (OSM) and its receptor OSMR r...
Molecular profiling of circulating tumor cells guides effective EGFR inhibitor treatment in advanced hepatocellular carcinoma: a case report [0.03%]
循环肿瘤细胞的分子分型指导晚期肝癌有效使用EGFR抑制剂治疗：一例报告
Wei Chiu,San-Chi Chen,Yee Chao et al.
Wei Chiu et al.
Circulating tumor cells (CTCs) hold promise for use in personalized medicine for hepatocellular carcinoma (HCC). Their abundance and molecular characteristics may predict disease prognosis and could be used to monitor responses to treatment...
HOXB7 drives bladder cancer progression via H-Ras/ERK signaling: a potential therapeutic target and prognostic biomarker [0.03%]
HOXB7通过H-Ras/ERK信号转导驱动膀胱癌进展：潜在的治疗靶点和预后生物标志物
Xulong Chen,Kehua Jiang,Kun Chen et al.
Xulong Chen et al.
Background: Bladder cancer (BC) is a common malignancy characterized by high recurrence and poor prognosis. HOXB7, a member of the HOX gene family, is aberrantly expressed in various tumors, but its role in BC remains unc...
The clinicopathological characteristics, oncologic outcomes and costs of "HER2-low" early breast cancer compared to HER2-zero and HER2-positive: a single-centre retrospective analysis [0.03%]
与HER2阴性和HER2阳性乳腺癌相比，“低HER2”乳腺癌的临床病理特征、肿瘤结局和成本：一项单中心回顾性分析
Patrícia Rafaela Rodrigues,Luísa Lopes-Conceição,Virgínia Sousa et al.
Patrícia Rafaela Rodrigues et al.
Background: Breast cancer is a heterogeneous disease commonly classified based on hormone receptor (HR) status and human epidermal growth factor receptor 2 (HER2) expression. Recently, an intermediate category termed "HER...
3D-printed biopolymer-based microneedle for enhanced photodynamic therapy in melanoma treatment [0.03%]
基于生物聚合物的微针3D打印技术在增强黑色素瘤光动力治疗中的应用研究
Aishat Adejoke Obalola,Heidi Abrahamse,Sathish Sundar Dhilip Kumar
Aishat Adejoke Obalola
Melanoma is a highly aggressive cancer with poor prognosis and resistance to many treatments, especially after metastasis. Developing new preventive and adjuvant therapies is critical for improving melanoma outcomes. Photodynamic therapy (P...
Integration of autophagy-related genes and immune dysregulation reveals a prognostic landscape in multiple myeloma [0.03%]
自噬相关基因与免疫失调的整合揭示了多发性骨髓瘤中的预后特征地图
Yibo Xia,Dong Zheng,Xinyi Zhang et al.
Yibo Xia et al.
Background: Autophagy is a self-renewal mechanism in which cells degrade damaged organelles or abnormal proteins through lysosomes. This process eliminates harmful components within the cell and maintains energy homeostas...
Anti-lipolysis-stimulated lipoprotein receptor antibody-drug conjugate to treat triple-negative breast cancer [0.03%]
抗脂解刺激性载脂蛋白受体的抗体药物偶联物治疗三阴性乳腺癌
Zhuoxin Zora Zhou,Davis Ballard,Tanvi Varadkar et al.
Zhuoxin Zora Zhou et al.
Triple-negative breast cancer (TNBC), the most aggressive breast cancer subtype (ER-/PR-/HER2-), is characterized by rapid proliferation, high metastatic rate and frequent recurrence. The development of targeted therapies for TNBC, such as ...
Tingyu Feng,Tianyang He,Wentao Ye et al.
Tingyu Feng et al.
FLASH radiotherapy (FLASH-RT) represents an innovative treatment modality utilizing ultra-high dose-rate irradiation (>40 Gy/s). The FLASH effect, induced by FLASH-RT, is characterized by the selective radioprotective effect of normal tissu...
Efficacy and safety of the S-1, nab-paclitaxel, and gemcitabine triplet regimen in patients with resected pancreatic ductal adenocarcinoma [0.03%]
S-1，白蛋白结合型紫杉醇和吉西他滨三联方案治疗胰腺导管腺癌术后患者的有效性和安全性评估研究
Donghui Ran,Cheng Geng,Zhongming Cha et al.
Donghui Ran et al.
Objective: To evaluate the safety, feasibility, and efficacy of an S-1-based triplet regimen (with nab-paclitaxel and gemcitabine) as adjuvant therapy following curative resection for pancreatic ductal adenocarcinoma (PDA...