Evidence and reality: an observational study on pharmacological outcomes in advanced head and neck tumors [0.03%]
基于头颈部晚期肿瘤的药理学结局观察研究的事实与证据
Consuelo Jordán de Luna,Anna Esteve Gomez,Olalla Montero Pérez et al.
Consuelo Jordán de Luna et al.
The Catalan Institute of Oncology (ICO) is a comprehensive centre for the prevention, diagnosis, and treatment of cancer. At the institute, there is a set of institutional clinical practice guidelines, named ICOPraxis. The field of oncology...
Remarkable tumor response to Iruplinalkib in a 14-year-old girl with ALK-positive advanced metastatic non-small-cell lung cancer: a case report [0.03%]
伊鲁帕利尼治疗ALK阳性青少年晚期非小细胞肺癌的显著疗效：病例报告
Jiahao Wang,Qingdi Du,Xueyan Sun et al.
Jiahao Wang et al.
Targeted therapies for anaplastic lymphoma kinase (ALK) mutations in non-small cell lung cancer (NSCLC) generally extend survival and alleviate symptoms. However, significant tumor reduction or complete remission remains rare. We report a r...
Impact of robotic-assisted versus video-assisted thoracoscopic surgery on efficacy and quality of life in patients with pulmonary opacities: a propensity score-matched analysis [0.03%]
机器人辅助与电视辅助胸腔镜手术对肺部病变患者疗效及生活质量的影响：倾向性评分匹配分析
Liuchun Huang,Shengjing Liang,Jing He et al.
Liuchun Huang et al.
Objective: With the increasing detection of pulmonary opacities through low-dose computed tomography (LDCT), minimally invasive surgical techniques have gained prominence. While debates persist regarding the comparative e...
NAP1L5 in acute myeloid leukemia: a prognostic biomarker and potential therapeutic target [0.03%]
NAP1L5在急性髓系白血病中的预后标志物和潜在治疗靶点研究
Meng Wang,Zhibin Xie,Yuanyuan Tan et al.
Meng Wang et al.
Background: Nucleosome assembly protein 1-like 5 (NAP1L5), a critical regulator of gene transcription and nucleosome assembly, has been implicated in the progression and poor prognosis of various cancers. However, its spe...
Global burden and cross-national inequalities of tobacco-attributable cancers in adults aged 40 and above, 1990-2021: a population-based study [0.03%]
1990年至2021年全球40岁以上成人由吸烟归因的癌症负担及国家间不平等：基于人群的分析
Yi Li,Hui Li,Lirui Tang et al.
Yi Li et al.
Background: Tobacco exposure substantially increases the global cancer burden; however, studies targeting specific subgroups are scarce. We aimed to investigate global burden trends of tobacco-attributable cancers among p...
Genetic variants and clinical determinants affecting the response to 5-Fluorouracil-based treatment in Chilean patients with advanced colorectal cancer [0.03%]
影响氟尿嘧啶类药物治疗晚期结直肠癌的遗传变异及临床因素——一项智利患者的回顾性研究
Leslie C Cerpa,Christopher Sandoval,Paula Escalante et al.
Leslie C Cerpa et al.
Background: Colorectal cancer is the second most prevalent cancer in Chile, affecting both sexes. Late-stage diagnosis occurs in approximately 25% of cases, with a five-year survival rate of only 14%. Standard treatment i...
Predictive model based on blood cell analysis and coagulation function indicators for neuroblastic tumors staging diagnosis [0.03%]
基于血细胞分析和凝血功能指标的神经母细胞瘤分期诊断预测模型
Yanzi Zhang,Lihong Zhang,Mengmeng Chen et al.
Yanzi Zhang et al.
Objective: To explore the diagnostic value of integrating blood cell analysis and coagulation function indicators in the staging of neuroblastic tumors, providing a robust basis for clinical decision-making. ...
NF-κB signaling pathway in osteosarcoma: from signaling networks to targeted therapy [0.03%]
骨肉瘤中NF-κB信号通路：从信号网络到靶向治疗
Juandi Xue,Xiao-Ran Yang,Li Wang
Juandi Xue
Osteosarcoma (OS) is the most common primary malignant bone tumor that frequently occurs in children and adolescents. Although neoadjuvant chemotherapy has shown efficacy for OS, the long-term survival rate of OS patients remains low, highl...
Nivolumab plus cabozantinib in metastatic renal cell carcinoma: real-world evidence from the international ARON-1 study [0.03%]
尼伏单抗联合卡博替尼治疗转移性肾细胞癌的国际真实世界证据——ARON-1研究
Maria T Bourlon,Luca Galli,Enrique Grande et al.
Maria T Bourlon et al.
Introduction: Four approved immune-based combinations for untreated metastatic renal carcinoma have demonstrated survival benefits. The ARON-1 study (NCT05287464) analyzed real-world data of patients with metastatic renal...
The effect of ubiquitination and deubiquitination to imatinib resistance in gastrointestinal stromal tumors [0.03%]
泛素化与去泛素化介导的胃肠道间质瘤伊马替尼耐药性研究进展
Huade Huo,Haolin Li,Xinlin Yang et al.
Huade Huo et al.
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor. Imatinib, as a receptor-type tyrosine kinase inhibitor (TKI), becomes a first-line drug for adjuvant therapy and prognosis. However, patients are facing with the pr...