Tong Liu,Tianhua Wu,Lijun Luo et al.
Tong Liu et al.
Sirtuins are a highly conserved family of NAD+-dependent deacetylases involved in regulating critical biological processes such as cell survival, antioxidation, gene transcription, proliferation, differentiation, DNA repair, and mitochondri...
Nomogram model for prognosis of early colorectal cancer after endoscopic therapy: integration of intestinal microbiota and clinicopathological parameters [0.03%]
内镜治疗早期结直肠癌预后预测模型的构建及肠道菌群的影响研究
Yanli Zhu,Fang Yang,Lijun Meng et al.
Yanli Zhu et al.
Objective: To integrate the characteristics of intestinal flora and clinical pathological parameters in patients with early colorectal cancer, and to construct and validate a nomogram model for predicting the prognosis of...
A novel missense mutation c.1381T>C: p.(S461P) in POLE causes multiple molecular features of endometrial carcinoma in China: a case report [0.03%]
POLE新型错义突变c.1381T>C：p.(S461P)导致中国子宫内膜癌患者出现多种分子特征：病例报告
Yingxue Li,Li Wang,Lin Han et al.
Yingxue Li et al.
Background: Accurately determining the pathogenicity of newly discovered POLE mutations is crucial for the precise molecular classification of endometrial carcinoma. ...
XPO1-inhibitor Selinexor induces MGMT expression by activating PKA-CREB signaling in IDH wildtype glioblastoma [0.03%]
XPO1抑制剂Selinexor通过激活PKA-CREB信号通路诱导MGMT表达以治疗IDH野生型胶质母细胞瘤
Josephine A Mapunda,Yuta Suzuki,Danielle Burgenske et al.
Josephine A Mapunda et al.
Purpose: The temozolomide (TMZ) resistance mechanisms in MGMT-promoter methylated IDH wildtype glioblastoma (GBM) tumors are poorly known. This study aimed to identify potential modulators of TMZ resistance in methylated ...
Immunotherapy in conversion therapy for gastric cancer: current status, progress, and challenges [0.03%]
胃癌转化治疗的免疫疗法：现状、进展与挑战
Yi Su,Xin Zhang,Wei Deng
Yi Su
Gastric cancer remains a global health burden due to its late diagnosis and poor prognosis. Conversion therapy aims to make the initially unresectable tumor resectable through systemic treatment, providing the opportunity for long-term surv...
Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study [0.03%]
肺癌腺癌遗传突变与成人BMI关系的回顾性队列研究
Yan Qiao Wu,Lei Yang,Depeng Jiang
Yan Qiao Wu
Background: The impact of obesity on gene mutations in lung adenocarcinoma(ADC) remains unclear. This study investigates the association between Body Mass Index(BMI) and the gene mutation in ADC. ...
Efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor as a support for chemotherapy for gestational trophoblastic neoplasia: a propensity score matching analysis [0.03%]
聚乙二醇化重组人粒细胞集落刺激因子用于妊娠滋养细胞肿瘤化疗支持的疗效及安全性：倾向性评分匹配分析
Xin Zhao,Hongwei Zhao,Lixin Sun et al.
Xin Zhao et al.
Background: Gestational trophoblastic neoplasia (GTN) is a highly malignant tumor that can be effectively treated with chemotherapy alone. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is used to rever...
Efficacy and safety of immune checkpoint inhibitor rechallenge therapy in the treatment of advanced acquired immune-resistant non-small cell lung cancer: a retrospective study [0.03%]
免疫检查点抑制剂挽救治疗获得性免疫抵抗的晚期非小细胞肺癌患者的有效性和安全性：一项回顾性研究
Jian Wang,Qijia Gao,Jianxin Chen
Jian Wang
Background: Patients with advanced non-small cell lung cancer who have failed first-line immunotherapy and lack driver gene mutations face limited options for subsequent treatment. A working group recently proposed update...
Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth [0.03%]
靶向RAB7的小分子抑制剂通过作用于人类B淋巴瘤而阻断肿瘤细胞生长
Maria Fernandez,Rui Wang,Jingwei Wang et al.
Maria Fernandez et al.
RAB7, encoded by RAB7A in humans and Rab7 in mice, is a small GTPase that catalyzes endosome maturation. It mediates NF-κB activation through the assembly of intracellular membrane signalosomes in stimulated normal B cells and plays a B ce...
Erdheim-Chester disease: unveiling hidden manifestations through two case reports [0.03%]
Erdheim-Chester病的诊断与治疗：两例罕见病例报道及文献复习
Guoxia Zhang,Xiaoqing Yang,Lei Fang et al.
Guoxia Zhang et al.
We present two cases of Erdheim-Chester disease (ECD) in 66-year-old female patients, highlighting their distinct clinical manifestations and diagnostic challenges. The first patient presented with chest tightness and dyspnea, revealing per...