Case Report: Relapsed alveolar rhabdomyosarcoma treated with abemaciclib, temozolomide, and irinotecan in the JPCS study [0.03%]
案例报告：在JPCS研究中用阿贝西利、替莫唑胺和伊立替康治疗复发性肺泡横纹肌肉瘤
Antonio Juan Ribelles,Nuria Benavent,Daniel Sanchez Mateos et al.
Antonio Juan Ribelles et al.
Background: Cyclin-dependent kinase (CDK) 4 and CDK6 play fundamental roles in cell cycle progression. The CDK4/6 inhibitor abemaciclib, in combination with temozolomide and irinotecan, was evaluated in pediatric and youn...
Low fT3/fT4 ratio as a proxy for muscle wasting in patients with advanced non-small cell lung cancer treated with pembrolizumab [0.03%]
低fT3/fT4比率可作为培美珠单抗治疗晚期非小细胞肺癌患者肌肉萎缩的替代指标
Serena Eccher,Marco Sposito,Ilaria Trestini et al.
Serena Eccher et al.
Background: Loss of skeletal muscle mass may serve as a valuable indicator of treatment efficacy and survival in individuals with lung cancer undergoing immunotherapy. This investigation sought to pinpoint accessible mark...
Development and validation of a prognostic nomogram for unresectable pancreatic ductal adenocarcinoma with synchronous liver metastases: a study based on the SEER database and an external cohort [0.03%]
基于SEER数据库和外部队列的同步肝转移不可切除胰腺导管腺癌预后 nomogram 的开发和验证
Lu Huan,Qi He,Yang Cao et al.
Lu Huan et al.
Background: Pancreatic ductal adenocarcinoma with synchronous liver metastases (PDACLM) represents a highly aggressive malignancy with limited treatment options and poor prognosis. While conversion therapy may enable cura...
Evaluating the safety and efficacy of SILS and SILS+1 port laparoscopic surgery for colorectal resection: a systematic review with meta-analysis and trial sequential analysis of RCTs [0.03%]
评估单孔腹腔镜手术（SILS）和增加一辅助孔的单孔腹腔镜手术（SILS+1）用于结直肠切除术的安全性和有效性：系统评价及基于随机对照试验的meta分析与序贯试验分析
Kai Lu,Shilong Shu,Furui Zhong et al.
Kai Lu et al.
Background: As minimally invasive techniques evolve, reduced-port laparoscopic colorectal resection, including single-incision (SILS) and single-incision plus one (SILS+1) approaches, has gained increasing clinical tracti...
Case Report: Cervical cancer masquerading as ovarian tumor: diagnostic challenges in a case with severe pyometra-pyocolpos complex [0.03%]
个案报告：作为卵巢肿瘤伪装的宫颈癌：严重宫腔积脓病例的诊断挑战
Chaoping Xie,Hongcen Liu,Daxia Huang et al.
Chaoping Xie et al.
Introduction and importance: Early-stage cervical cancer, which is often asymptomatic, presents considerable diagnostic difficulties when accompanied by vaginal adhesions that conceal malignant lesions. In this report, we...
Comparison of Albumin-Bilirubin, Platelet-Albumin-Bilirubin, and Child-Pugh scores to predict overall survival in patients with stage C hepatocellular carcinoma with liver cirrhosis treated with c-TACE [0.03%]
比较ALBI，PALBI和Child-Pugh评分在肝硬化患者经导管动脉化疗栓塞治疗C期肝细胞癌中预测总体生存率的价值
Fei Wu,Zhihong Zhang,Shanshan Liu
Fei Wu
Purpose: This study aimed to evaluate and compare the prognostic performance of Albumin-Bilirubin (ALBI), Platelet-Albumin-Bilirubin (PALBI), and Child-Pugh (CP) scores in predicting overall survival (OS) among patients w...
Isolated hypoxic pelvic perfusion combined with electroporation is a valid alternative to traditional therapies for anal squamous cell carcinoma: a case study [0.03%]
孤立缺氧盆腔灌注联合电穿孔治疗肛鳞状细胞癌的病例研究
Karl R Aigner,Kornelia Aigner,Marc J H Hendrikx et al.
Karl R Aigner et al.
Introduction: We report a series of four patients with HPV-positive squamous cell carcinoma of the anus: two with non-previously treated grade G3 malignancies, and two with relapsing G2 tumors in progression after chemora...
Identification of key genes associated with perineural invasion in stage II colorectal cancer and their prognostic implications [0.03%]
鉴定II期结直肠癌相关的感觉神经侵袭的关键基因及预后意义
Chen Chang,Bin Zhang,Jingli Chen et al.
Chen Chang et al.
Objective: This study aimed to identify key genes associated with perineural invasion (PNI) in stage II colorectal cancer (CRC) and develop a prognostic nomogram. The goal was to create a model for more precise prognosis ...
Case Report: Recurrent supraglottitis in a patient with metastatic melanoma treated with ipilimumab and nivolumab [0.03%]
案例报告：ipilimumab和nivolumab治疗的转移性黑色素瘤患者的复发性声门上炎
Marisa Palmeri,Sarah A Weiss,Phillip Purnell
Marisa Palmeri
Background: Immune checkpoint inhibitors (ICIs) are a standard of care for advanced melanoma but have the potential to cause immune-related adverse events (irAEs), which can vary widely in character and severity. Immune-r...
Integration of single-cell and bulk RNA sequencing to identify unique tumor stem cells and construct novel prognostic markers for assessing ESCA prognosis and drug sensitivity [0.03%]
整合单细胞和批量RNA测序以识别独特的肿瘤干细胞并构建新的预后标志物以评估食管癌预后和药物敏感性
Jia Shi,Danni Qiao,Qiongyang Lv et al.
Jia Shi et al.
Background: Cancer stem cells (CSCs) are crucial contributors to the development and progression of esophageal cancer (ESCA). This study utilized single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (RNA-seq) to...