Trial in progress: phase I study of non-viral gene-modified CAR-T cell therapy for malignant solid tumors expressing EPHB4 receptor (CARTiEr) [0.03%]
正在进行中的I期临床试验：针对表达EPHB4受体恶性实体肿瘤的非病毒基因修饰CAR-T细胞疗法（CARTiEr）
Chikako Funasaka,Yoichi Naito,Hitomi Kubota et al.
Chikako Funasaka et al.
Background: Ephrin type-B receptor 4 (EPHB4) is overexpressed on the surface of various tumor cells, including cells from malignant bone and soft-tissue tumors. AP8901 CAR-T cell therapy can specifically recognize and kil...
Impact on outcomes of ultra hypofractionation or hypofractionation regimens and proton or Xrays therapy in a phase III randomized controlled trial MC1635 [0.03%]
超分割与常规超分割及质子和X射线治疗对结果影响的III期随机对照试验（研究编号MC1635）
Carlos Vargas,Kimberly Corbin,Lisa McGee et al.
Carlos Vargas et al.
Postoperative microcystic meningioma of the fourth ventricle with subsequent giant cell reparative granuloma: a case report [0.03%]
第四脑室术后微囊性脑膜瘤并发巨大细胞修复性肉芽肿1例报告
Fangfang Xu,Chengzhi Fu,Qian Li et al.
Fangfang Xu et al.
Background: Microcystic meningioma (MM) is a distinctive benign tumor typically located in the supratentorial region. Giant cell reparative granuloma (GCRG) is another rare reactive benign lesion associated with surgical ...
Time tO last ChemotherApy and death in ovaRian cancEr patients: TO CARE/MITO 42 study, a retrospective analysis of italian MITO centers [0.03%]
意大利MITO中心卵巢癌患者最后一次化疗与死亡时间的回顾性分析：TO CARE/MITO 42 研究
Giulia Scotto,Anna Galatà,Robert Fruscio et al.
Giulia Scotto et al.
Introduction: The European Society for Medical Oncology (ESMO) 2021 Guidelines contraindicate the administration of chemotherapy in the last month of patients' life. The main objective of this multicenter observational re...
The pathogenesis of benign prostatic hyperplasia and the roles of Prdx3, oxidative stress, pyroptosis and autophagy:a review [0.03%]
前列腺增生的发生机制及过氧化物酶体生物素(peroxisome proliferator activated receptor)𞢺三型（Prdx3）、氧化应激、细胞焦亡和自噬的作用：综述
Junjie Xiang,Yuxuan Zheng,Diang Chen et al.
Junjie Xiang et al.
Benign prostatic hyperplasia (BPH) is driven by hormonal and inflammatory mechanisms, yet emerging factors such as peroxiredoxin 3 (Prdx3), oxidative stress (OS), pyroptosis, and autophagy remain understudied. This review synthesizes their ...
Chorordin-like 1 inhibits pancreatic cancer cell migration and invasion: involvement of the BMP4/SMAD pathway [0.03%]
视黄酸诱导基因CHORDC1通过BMP4/Smad信号通路抑制胰腺癌的侵袭和转移
Wei Li,Yalan Zhong,Yuqiao Song et al.
Wei Li et al.
Introduction: Pancreatic cancer is a highly aggressive malignancy with a 6% five-year survival rate. CHRDL1, a BMP4 antagonist, has tumor-suppressive effects in breast and gastric cancers, but its role in pancreatic cance...
Overexpression of BNIP3 in renal carcinoma cells can promote apoptosis of renal carcinoma cells through HIF-1α-BNIP3-mediated autophagy [0.03%]
BNIP3在肾癌细胞中的过表达可以通过HIF-1α-BNIP3介导的自噬促进肾癌细胞凋亡
Long Huang,Lin Wang,Dan Yuan et al.
Long Huang et al.
Background: Renal cell carcinoma (RCC) is a prevalent malignancy with limited effective therapies, necessitating novel molecular targets. BNIP3, a pro-apoptotic protein regulated by hypoxia-inducible factor 1 (HIF-1), is ...
SPOCK1 promotes the progression of breast cancer by modulating cancer-associated fibroblasts and exerts a synergistic effect with ANXA2 [0.03%]
SPOCK1通过调控癌相关成纤维细胞促进乳腺癌进展并表现出与ANXA2的协同效应
Yuan Jie,Xin Fei,Meng Fan
Yuan Jie
Background: SPOCK1, a matricellular glycoprotein, has been implicated in tumor progression, metastasis, and the tumor immune microenvironment, yet its specific roles in breast cancer (BRCA) remain unclear. This study aime...
Wei He,Zhen Wang,ZiHan Li
Wei He
Bone metastasis, an exceedingly critical and often life - threatening complication in the course of diverse cancer progression, impacts nearly all tumor types, with an especially pronounced prevalence in breast, prostate, lung, liver, and t...
A phase I study of S-1 and cisplatin with concurrent hypofractionated carbon-ion radiotherapy for patients with stage III non-small cell lung cancer [0.03%]
评价S1联合顺铂同步低分割碳离子放疗治疗III期非小细胞肺癌的I期临床研究
Yosuke Miura,Nobuteru Kubo,Noriaki Sunaga et al.
Yosuke Miura et al.
Objectives: We conducted a phase I study to evaluate the recommended dose of S-1 in combination with cisplatin (SP) and concurrent carbon ion radiotherapy (CIRT) in patients with stage III locally advanced non-small cell ...