BrainTumNet: multi-task deep learning framework for brain tumor segmentation and classification using adaptive masked transformers [0.03%]
基于自适应掩码变压器的脑肿瘤分割和分类多任务深度学习框架
Cheng Lv,Xu-Jun Shu,Quan Liang et al.
Cheng Lv et al.
Background and objective: Accurate diagnosis of brain tumors significantly impacts patient prognosis and treatment planning. Traditional diagnostic methods primarily rely on clinicians' subjective interpretation of medica...
Iodine-131 induces ferroptosis and synergizes with sulfasalazine in differentiated thyroid cancer cells via suppressing SLC7A11 [0.03%]
碘131通过抑制SLC7A11在分化型甲状腺癌细胞中诱导铁死亡并协同水杨酸类药物的作用
Li Ling,Jinhe Zhang,Xiao Zhang et al.
Li Ling et al.
Iodine-131 (131I) plays a key role in the treatment of differentiated thyroid cancer (DTC). Ferroptosis represents a form of regulated cell death that is distinct from necrosis and apoptosis, constituting a unique mode of programmed cell de...
MDPNet: a dual-path parallel fusion network for multi-modal MRI glioma genotyping [0.03%]
基于双轨并行融合网络的多模态磁共振胶质瘤分型方法(MDPNet)
Huaizhi Wang,Haichao Liu,Fang Du et al.
Huaizhi Wang et al.
Background: Glioma stands as one of the most lethal brain tumors in humans, and its accurate diagnosis is critical for patient treatment and prognosis. Magnetic Resonance Imaging (MRI) has been widely utilized for glioma ...
Preclinical NCI-MPACT: prospective modeling of the mutation-based NCI-MPACT clinical trial therapeutic strategy in patient-derived xenograft models [0.03%]
基于患者来源的小鼠异种移植模型的NCI-MPACT临床试验治疗策略的前瞻性建模：预临床研究
Yvonne A Evrard,Sergio Y Alcoser,Michael Mullendore et al.
Yvonne A Evrard et al.
Purpose: The National Cancer Institute's Molecular Profiling-Based Assignment of Cancer Therapy (NCI-MPACT) randomized phase 2 clinical trial assessed the utility of applying tumor DNA sequencing to treatment selection. H...
Diagnostic significance of the novel biomarker combination for early-stage non-small cell lung cancer detection: results of the blind clinical study [0.03%]
新型生物标志物组合在早期肺癌诊断中的价值：盲法临床研究结果
Janneta Tcherkassova,Evgueni Klinski,Sergey Tsurkan et al.
Janneta Tcherkassova et al.
Background: NSCLC can be cured in up to 65% of cases if detected early. However, most of the lung cancer (LC) cases are diagnosed at an advanced stage. Ob...
Combined CA125, NSE, and multiple inflammatory indices for diagnosis of oral squamous cell carcinoma [0.03%]
联合检测CA125、NSE和多种炎症指标诊断口腔鳞癌
Kudelaiti Abudukelimu,Ailifeire Tuerxuntayi,Aikepaer Aierken et al.
Kudelaiti Abudukelimu et al.
Objective: To investigate the changes of serum carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic inflammation response index ...
Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival [0.03%]
泛素特异性蛋白酶USP23通过去泛素化和激活FAK来促进晚期甲状腺癌细胞生长和存活的新机制研究
Meghan D Kellett,Vibha Sharma,Madeline E Sherlock et al.
Meghan D Kellett et al.
Introduction: Advanced thyroid cancer, including papillary (PTC) and anaplastic thyroid cancer (ATC), are the leading causes of endocrine cancer deaths. Thus, there is a critical need to identify novel therapeutic targets...
Novel insights into the N 6-methyladenosine modification on circRNA in cancer [0.03%]
circRNA在癌症中的N6-甲基腺苷修饰的新见解
Qingling Xu,Yi Jia,Ying Liu et al.
Qingling Xu et al.
Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) generated through the reverse splicing of mRNA precursors (pre-mRNAs). They possess a unique loop structure and exhibit remarkable stability. CircRNAs have emerged as promisin...
Identification of novel prognostic biomarkers for thyroid cancer by integrated transcriptome analysis of metastasis-associated genes [0.03%]
整合转移相关基因转录组分析鉴定甲状腺癌预后生物标志物
Bushra Alnwisser,Salman Alshehri,Amal Qattan et al.
Bushra Alnwisser et al.
Introduction: Distant metastasis (DM) is the most important prognostic factor affecting the overall survival (OS) of thyroid cancer. The current study aimed to discover prognostic biomarkers to predict thyroid cancer surv...
The CENPN/STAT3/USP37 signaling axis promotes invasion, migration and metastasis in nasopharyngeal carcinoma [0.03%]
CENPN/STAT3/USP37信号轴促进鼻咽癌侵袭、迁移和转移的作用及机制研究
Yu-Fei Wang,You Zou,Yue-Long Qiao et al.
Yu-Fei Wang et al.
Background: Nasopharyngeal carcinoma (NPC) metastasis is the main cause of poor treatment outcomes and death in nasopharyngeal carcinoma patients. Previously, we reported that centromere protein N (CENPN) is closely relat...