Total neoadjuvant chemoradiotherapy plus anti PD-1 for mid-to-low locally advanced rectal cancer: study protocol of a prospective, single arm, phase II study (STARS - RC06) [0.03%]
局部晚期中低危直肠癌新辅助放化疗联合抗PD-1治疗的临床研究方案（STARS-RC06）
Meichen Gu,Yuchen Guo,Liang He et al.
Meichen Gu et al.
Background: Neoadjuvant chemoradiotherapy has become the standard treatment for mid-to-low location LARC. Recently, total neoadjuvant therapy (TNT) has been used in patients with 'high-risk' or 'very high-risk' LARC accor...
Application of chemotherapy combined with immunotherapy in first-line treatment of advanced esophageal cancer: fluorouracil or paclitaxel? - a meta-analysis [0.03%]
化疗联合免疫治疗一线治疗晚期食管癌：氟尿嘧啶还是紫杉醇？- 一项系统评价和网状Meta分析
Xiaochen Chen,Huiping Yan,Hongyang Zhao et al.
Xiaochen Chen et al.
Introduction: Immunotherapy combined with chemotherapy is now the first-line standard for metastatic/recurrent esophageal cancer, with rapid immunotherapy advancements significantly improving patient outcomes. Internation...
The efficacy and safety of submucosal tunnel endoscopic resection for the treatment of upper gastrointestinal submucosal tumors: a systematic review and meta-analysis [0.03%]
内镜下黏膜下隧道技术切除上消化道黏膜下肿瘤疗效和安全性的系统评价和meta分析
Hong Liu,Qing Ma,Linlin Zhu
Hong Liu
Objective: The comprehensive systematic review was conducted to assess the efficacy and associated factors of submucosal tunnel endoscopic resection (STER) in the treatment of upper gastrointestinal submucosal tumor. ...
Case Report: Application of ex-vivo drug sensitivity testing to identify personalized treatment options for an adolescent with diffuse midline glioma [0.03%]
个例报告：体外药物敏感性检测在青少年弥漫轴心胶质瘤个性化治疗中的应用
Philip K Tan,Timothy J Martins,Pamela S Becker et al.
Philip K Tan et al.
Diffuse midline glioma (DMG) is a pediatric brain cancer that has a dismal prognosis with limited treatment options. We present the treatment course and outcome of an adolescent male diagnosed with a thalamic DMG carrying a histone H3.3 K27...
Acute thrombocytopenia and fibrinogen reduction occurring after nintedanib treatment for immune checkpoint inhibitor-related pneumonia: a case report [0.03%]
尼达尼布治疗免疫检查点抑制剂相关肺炎后出现急性血小板减少和纤维蛋白原降低的1例报告
Jian Zheng,Nan Zhou,Dexiang Pang
Jian Zheng
Background: Nintedanib, a small molecule multi-target tyrosine kinase inhibitor, can block the fibrosis process and slow disease progression. Acute thrombocytopenia and fibrinogen reduction caused by nintedanib is a rare ...
The efficacy and immune-mediated safety of PD-1/PD-L1 combined with neoadjuvant chemotherapy in triple-negative breast cancer: a meta-analysis [0.03%]
PD-1/PD-L1抑制剂联合新辅助化疗在三阴性乳腺癌中的疗效和免疫相关安全性：一项系统评价和Meta分析
Xiao Yan,Qi Lv,Jiangzhuo Wu et al.
Xiao Yan et al.
Background: The efficacy and immune-mediated safety of PD-1/PD-L1 inhibitors in triple-negative breast cancer (TNBC) remain controversial. Given TNBC's aggressive biology and poor prognosis, definitive evidence is urgentl...
Case Report: A rare case of ALK-KIF5B gene fusion benefited from treatment with lorlatinib [0.03%]
病例报告：一例罕见的ALK-KIF5B基因融合患者接受洛拉替尼治疗获益
Yuxi Luo,Weiwei Ouyang
Yuxi Luo
The anaplastic lymphoma kinase (ALK) gene encodes a transmembrane receptor tyrosine kinase. Most mutations in ALK gene result from translocations with other genes, forming fusion oncogenes. To date, 21 different genes have been identified a...
Digital pathology-based artificial intelligence model to predict microsatellite instability in gastroesophageal junction adenocarcinomas [0.03%]
基于数字病理学的AI模型预测胃食管结合部腺癌微卫星不稳定型
Zhenqian Li,JingQi Chen,Miaomiao Sun et al.
Zhenqian Li et al.
Purpose: Microsatellite instability (MSI) plays a crucial role in determining the therapeutic outcomes of gastroesophageal junction (GEJ) adenocarcinoma. This study aimed to develop a deep learning model based on H&E-stai...
Case Report: Complete response with combination oncolytic virus immunotherapy in a patient with stage IV renal cell carcinoma-a promising innovative approach [0.03%]
案例报告：一名IV期肾细胞癌患者采用溶瘤病毒联合免疫治疗获得完全缓解——一种有前景的创新疗法
Benjamin Gesundheit,Chaim Brauns,Thomas J Vogl et al.
Benjamin Gesundheit et al.
Metastatic renal cell carcinoma stage IV (RCC-IV) remains a therapeutic challenge, with an overall 5-year survival rate of 12%. Conventional chemotherapy and radiotherapy have shown relatively low efficacy in reducing morbidity and mortalit...
Clinical and prognostic outcomes of colposcopy-guided LEEP versus cold knife conization in the management of cervical intraepithelial neoplasia [0.03%]
宫颈内上皮瘤变的治疗中，阴道镜引导下的环形电切术与冷刀锥切术的临床及预后结局比较
Fengying Jin,Lingling Wang,Zhan Su
Fengying Jin
Objective: To evaluate the clinical effectiveness and prognostic outcomes of colposcopy-guided LEEP compared with cold knife conization (CKC) in the treatment of cervical intraepithelial neoplasia (CIN). ...