Machine learning-based identification of core regulatory genes in hepatocellular carcinoma: insights from lactylation modification and liver regeneration-related genes [0.03%]
基于机器学习识别肝细胞癌中的核心调控基因：乳酰化修饰和肝脏再生相关基因的启示
Yu Yang,Yiwei Hou,Li Yi et al.
Yu Yang et al.
Introduction: Hepatocellular carcinoma (HCC) progression shares metabolic-epigenetic features with physiological liver regeneration, yet the regulatory interplay remains poorly defined. We hypothesize that lactylation, a ...
Circ_0060927 regulates miR-331-3p/ERK/MAPK pathway reaction in non-small cell lung cancer through METTL14-driven methylation [0.03%]
METTL14介导的甲基化通过调节miR-331-3p/ERK/MAPK途径调控环状RNA circ_0060927在非小细胞肺癌中的作用
Yang Liao,Ji Song,Chun Luo et al.
Yang Liao et al.
Background: Non-coding RNA is one of the most paramount genetic regulators. circRNAs (Circular RNAs) are a potential modulator of various tumors, especially in non-small cell lung cancer (NSCLC). This study focused on elu...
Phytochemical and nanoparticle-based therapeutic potential of Sphaeranthus indicus against hepatocellular carcinoma via cryptomeridiol targeting [0.03%]
Sphaeranthus indicus的植物化学和纳米药物治疗潜力通过隐花醇靶向对抗肝细胞癌
Ritika Ravindra Konduskar,Abhinandan R Patil,Somnath D Bhinge et al.
Ritika Ravindra Konduskar et al.
Background: Cancer remains a major global health challenge, and despite advances in chemotherapy, there is a need for safer plant-derived therapeutics. Sphaeranthus indicus (Si) (East Indian globe thistle), traditionally ...
Yue Shen,Shuzhou Huang,Geng Chen et al.
Yue Shen et al.
Osteosarcoma (OS), the most common primary malignant bone tumor, remains a therapeutic challenge because of its high metastatic potential, chemoresistance, and poor prognosis. Mutations in the TP53 tumor suppressor gene, including loss-of-f...
Predictive performance of MRI and CT radiomics in predicting the response to induction chemotherapy in nasopharyngeal carcinoma: a network meta-analysis [0.03%]
放射组学在预测鼻咽癌诱导化疗疗效中的预测性能：网络meta分析研究
Yongjie Jian,Jiaxuan Peng,Gan Yang et al.
Yongjie Jian et al.
Objectives: To evaluate the accuracy of different radiomics methods in predicting the response of nasopharyngeal carcinoma (NPC) to induction chemotherapy (IC). ...
Best evidence summary for self-management of radiodermatitis in head and neck cancer patients: an integrative review [0.03%]
头颈部癌症放射性皮炎的自我管理的最佳证据总结：整合回顾
Lianfang Cheng,Mingqi Zhang,Yicen Zheng et al.
Lianfang Cheng et al.
Aim: To evaluate and synthesize the best evidence for radiodermatitis self-management in head and neck cancer (HNC) patients, and to provide evidence-based guidance for improving their self-management capabilities. ...
Editorial: Antibody-based novel target immunotherapy in hematological malignancy [0.03%]
编辑评论：基于抗体的新型靶向免疫治疗在血液系统恶性肿瘤中的应用
Weijie Cao,Yingmei Li,Haizhou Xing et al.
Weijie Cao et al.
Case Report: FGFR1 mutation and massive chromosome loss drive malignant transformation of low-grade gliomas [0.03%]
案例报告：FGFR1突变和大量染色体丢失驱动低级别胶质瘤恶性转化
Ruze Tang,Yanming Chen,Dong Wan et al.
Ruze Tang et al.
The mitogen-activated protein kinase (MAPK) signaling pathway plays roles in cell proliferation, differentiation, and apoptosis, all crucial for cellular transformation. It's no surprise that MAPK alterations are prevalent in numerous tumor...
CD302 regulates the malignant phenotypes of lung adenocarcinoma as a tumor suppressor gene [0.03%]
CD302作为肿瘤抑制基因调节肺腺癌恶性表型
Kai Wang,Yao Wang,Tao Lu et al.
Kai Wang et al.
Background: CD302 encodes a transmembrane glycoprotein involved in immune regulation via cell-extracellular matrix interactions. Its role in lung adenocarcinoma (LUAD) remains unexplored. This study investigates CD302's e...
Adjuvant tyrosine kinase inhibitors plus anti-PD-1 therapy reduce recurrence in high-risk hepatocellular carcinoma after resection [0.03%]
术后的辅助酪氨酸激酶抑制剂联合抗PD-1治疗可降低高危肝细胞癌复发风险
Jiaxin Li,Yukun Sun,Ziniu Liu et al.
Jiaxin Li et al.
Background/aims: No standardized adjuvant treatment has been established for patients with hepatocellular carcinoma (HCC) following curative resection. This study aimed to evaluate the efficacy and safety of adjuvant tyro...