CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway [0.03%]
CD9通过激活AKT/GSK3β信号通路调节食管鳞癌的增殖、侵袭、迁移和放疗抵抗能力
Liubing Hou,Zengyao Hao,Ge Zhang et al.
Liubing Hou et al.
Background: Radioresistance poses a major therapeutic challenge in ESCC, significantly impacting patient prognosis. CD9, as a crucial membrane regulatory protein, exhibits dual regulatory roles in various cancers, yet its...
Case Report: Uncommon presentation of Ewing sarcoma complicated by hemophagocytic lymphohistiocytosis: a diagnostic dilemma and therapeutic challenge [0.03%]
个例报道：Ewing肉瘤合并噬血细胞综合征的罕见表现：诊断困难和治疗挑战
Zhuan Zou,Bin Chen,Fajuan Tang et al.
Zhuan Zou et al.
Hemophagocytic lymphohistiocytosis (HLH), also referred to as hemophagocytic syndrome (HPS), is a life-threatening condition characterized by excessive immune activation. It is commonly associated with genetic mutations, infections, autoimm...
Imaging features of CT and MR in hepatic perivascular epithelioid cell tumor: case series and literature review [0.03%]
CT和MR在肝血管周上皮样细胞肿瘤中的影像学特征：病例系列及文献复习
Ning Li,Hui Liu,Jing Chen et al.
Ning Li et al.
Objective: To retrospectively analyze the clinical and imaging data of 4 patients with hepatic PEComa of different pathological grades, and to review relevant literature, aiming to enhance clinical awareness of this disea...
Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma [0.03%]
头颈鳞癌中评估个体对免疫检查点治疗反应的多重免疫谱分析及共培养实验
Verena Schweihofer,Daniela Schulz,Raquel Blazquez et al.
Verena Schweihofer et al.
Background: Immune checkpoint inhibitors (ICIs) have become an integral part of cancer therapy, but only a minority of patients experience durable responsiveness. Response rates vary greatly and are often unpredictable, h...
Meta-analysis on the safety and efficacy of Erdafitinib in treating FGFR1-4 mutated solid tumors [0.03%]
艾达非尼布治疗FGFR1-4突变的实体瘤有效性和安全性的meta分析研究
Jiyu Huang,Zihan Wang,Fei Zhao et al.
Jiyu Huang et al.
Objective: This article aims to analyze the safety and efficacy of Erdafitinib in the treatment of patients with advanced solid tumors harboring FGFR1-4 mutations. ...
Safety of unconventional antibody-drug conjugate L-DOS47 in a phase I/II monotherapy study targeting advanced NSCLC [0.03%]
关于非传统抗体药物偶联物L-DOS47单药治疗晚期非小细胞肺癌的I/II期临床研究的安全性分析
Rodryg Ramlau,Dariusz M Kowalski,Aleksandra Szczęsna et al.
Rodryg Ramlau et al.
Introduction: Tumor acidity is emerging as a hallmark of cancer and carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) expression is frequently increased in acidic tumors. L-DOS47, a novel antibody-drug c...
A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer [0.03%]
随机双盲安慰剂对照研究天麻灵芝菌丝剂量及治疗结直肠癌奥沙利铂诱导的外周神经病变的有效性
Shogen Boku,Hironaga Satake,Seiichiro Mitani et al.
Shogen Boku et al.
Introduction: Preclinical studies have demonstrated the potential of Lentinula edodes mycelium (L.E.M.) extract for managing oxaliplatin-induced peripheral neuropathy (OIPN). The efficacy and optimal dosage of L.E.M. for ...
CHAC1 in urological tumors: contextual dualism and therapeutic implications [0.03%]
泌尿系统肿瘤中的CHAC1：背景二重性及治疗意义
Deyu Wang,Yongquan Wan,Yunxiang Li et al.
Deyu Wang et al.
CHAC1, a glutathione-degrading enzyme, governs context-dependent pathophysiological processes in urological malignancies through modulation of endoplasmic reticulum stress and ferroptotic pathways. In clear cell renal cell carcinoma (ccRCC)...
Chinese expert consensus on imaging examination and diagnosis of nasal cavity and paranasal sinus tumors [0.03%]
鼻腔及鼻窦肿瘤影像检查和诊断中国专家共识
Xunan Zhang,Yi Zhang,Lixiao Chen et al.
Xunan Zhang et al.
The complex anatomy and diverse tissue composition of the nasal cavity and paranasal sinuses contribute to a wide variety of tumor pathologies in this region, posing significant diagnostic challenges in clinical practice. Evaluation with co...
Evaluating treatment strategies and machine learning based treatment recommendation system for elderly patients with high grade gliomas [0.03%]
老年高度恶性的胶质瘤患者的治疗策略评估及基于机器学习的治疗推荐系统
Feiling Xiang,Mengyuan Fu,Xuelian Yang
Feiling Xiang
Background: When selecting treatment strategies, elderly high-grade glioma (eHGG) patients face challenges due to aging, comorbidities, surgical complications, and limited tolerance for intensive treatments. This study ai...