Combination therapy of TKIs and ICIs for the treatment of anaplastic thyroid carcinoma [0.03%]
TKI和ICI联合治疗间变性甲状腺癌
Xi Zhang,Hongzhi Lu,Yuanshi Lv et al.
Xi Zhang et al.
Objective: To explore the efficacy of combination therapy of tyrosine kinase inhibitor (TKIs) and immune checkpoint inhibitor (ICIs) in patients with anaplastic thyroid carcinoma (ATC). ...
A PET-CT radiomics model for immunotherapy response and prognosis prediction in patients with metastatic colorectal cancer [0.03%]
转移性结直肠癌免疫治疗反应和预后预测的PET-CT影像组学模型
Wenbiao Chen,Peng Zhu,Yeda Chen et al.
Wenbiao Chen et al.
Background: In recent years, radiomics, as a non-invasive method, has shown potential in predicting tumor response and prognosis by analyzing medical image data to extract high-dimensional features and reveal the heteroge...
tRF-1:28-Val-CAC-2 promotes the development of nasopharyngeal cancer by targeting EPHB2 [0.03%]
tRF-1:28-Val-CAC-2通过靶向EPHB2促进鼻咽癌的发展
Hui Li,Xiaomin Wang,Anchi Sun et al.
Hui Li et al.
Introduction: Nasopharyngeal carcinoma (NPC) is highly aggressive, with a particularly high incidence in South China. is an aggressive cancer that affects particularly high numbers of patients in southern China and Southe...
CAR T- cell therapy provides an opportunity for further consolidation treatment for relapsed or refractory adult Burkitt lymphoma patients [0.03%]
CAR-T细胞治疗为复发或难治成人Burkitt淋巴瘤患者进一步巩固治疗提供了机会
Rui Liu,Fan Yang,Lixia Ma et al.
Rui Liu et al.
Background: Relapsed or refractory (R/R) Burkitt lymphoma (BL) in adults is aggressive and lacks standardized salvage options. Data on the efficacy and safety of chimeric antigen receptor T (CAR-T) cell therapy in this po...
Interpretable machine learning model integrating contrast-enhanced CT environmental radiomics and clinicopathological features for predicting postoperative recurrence in lung adenocarcinoma: a retrospective pilot study [0.03%]
结合增强CT环境组学和临床病理特征的可解释机器学习模型预测肺腺癌术后复发：回顾性试点研究
Song Lin,Yanli Niu,Lina Song et al.
Song Lin et al.
Purpose: This study aims to develop an interpretable predictive model combining contrast-enhanced CT (CECT) radiomics features with clinicopathological parameters to assess 3-year recurrence risk after surgery for lung ad...
Second-line chemotherapy rechallenge in lung cancer patients: a Moroccan real-world study [0.03%]
肺癌患者的二线化疗再挑战：一项摩洛哥的真实世界研究
Hassan Abdelilah Tafenzi,Farah Choulli,Ismail Essadi et al.
Hassan Abdelilah Tafenzi et al.
Background: Immune checkpoint inhibitors are the go-to therapeutic option for relapsed non-small cell lung cancer (NSCLC) with unidentified oncogenic drivers when first-line platin doublet chemotherapy fails. Meanwhile, f...
Targeting the leptin receptor promotes MDA-MB-231 cells' metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue [0.03%]
靶向瘦素受体促进MDA-MB-231细胞的代谢重构和恶性发展：来自肥胖脂肪组织的外泌体的作用
Carol Costa Encarnação,Carolinne Souza Amorim,Victor Aguiar Franco et al.
Carol Costa Encarnação et al.
Introduction: Leptin, a key adipokine secreted by adipose tissue (AT), has emerged as a critical mediator linking obesity and breast cancer, both of which are major global health concerns. Elevated leptin levels are detec...
A recent evaluation on the performance of LLMs on radiation oncology physics using questions of randomly shuffled options [0.03%]
近期使用随机排列选项的问题评估辐射肿瘤物理学中大语言模型的性能
Peilong Wang,Jason Holmes,Zhengliang Liu et al.
Peilong Wang et al.
Purpose: We present an updated study evaluating the performance of large language models (LLMs) in answering radiation oncology physics questions, focusing on the recently released models. ...
Upregulation of stomatin is associated with poor prognosis and promotes tumor progression of orbital diffuse large B-cell lymphoma [0.03%]
STMN1上调与眼眶弥漫大B细胞淋巴瘤的不良预后及肿瘤进展相关
Wen Chen,Jingyi Chi,Weichen Song et al.
Wen Chen et al.
Introduction: Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin's lymphoma that predominantly affects the elderly and carries a poor prognosis. When arising in the orbit, DLBCL is characterized...
The dual effects of macrophage-derived extracellular vesicles on tumor cell behavior: mechanisms and clinical potential [0.03%]
巨噬细胞源外泌体对肿瘤细胞行为的双重影响：机制与临床潜力
Jia-Wen Tian,Yu-Han Fang,He-Jing Zhang et al.
Jia-Wen Tian et al.
Macrophages, key players in the immune system, exhibit diverse roles in tumor progression and regulation. Macrophages release extracellular vesicles (EVs), membrane-bound particles that facilitate intercellular communication and cargo trans...