Case Report: Unlocking opportunities in HER2-targeted antibody-drug conjugates for bulky leptomeningeal metastatic breast cancer [0.03%]
病例报告：针对肿瘤负荷较大脑膜转移性乳腺癌的HER2靶向抗体药物偶联物治疗机遇解锁
Alessandro Leal,Douglas Kondziolka,Donato Pacione et al.
Alessandro Leal et al.
Leptomeningeal carcinomatosis (LC) is a severe complication of metastatic breast cancer (mBC), with rising incidence. The prognosis for patients with LC has been poor, with a median overall survival of approximately four months. However, re...
Epstein-Barr virus-driven molecular pathogenesis of primary pulmonary lymphoepithelial carcinoma [0.03%]
EB病毒所致原发性肺淋巴上皮瘤样癌的分子发病机制研究
Mingyuan Xie,Dong Yao,Liping Lei et al.
Mingyuan Xie et al.
Primary Pulmonary Lymphoepithelial Carcinoma (PLEC) is a rare subtype of non-small cell lung cancer (NSCLC) that exhibits a strong association with Epstein-Barr virus (EBV) infection and shows distinctive geographic and ethnic predilections...
Multidisciplinary strategies to reduce radiotherapy-induced cardiotoxicity in breast cancer: surgical and technological innovations [0.03%]
乳腺癌放射治疗引起的心脏毒性的多学科防治策略：手术及技术新进展
Kai Lu,Zhenhua Sun,Yide Yi
Kai Lu
Radiotherapy remains essential in breast cancer management, yet its long-term cardiotoxicity, driven primarily by radiation-induced myocardial fibrosis, threatens survivorship, particularly in left-sided tumors. Surgical refinements, includ...
Deep learning radiomics nomogram predicts lymph node metastasis in laryngeal squamous cell carcinoma [0.03%]
基于深度学习的影像组学列线图预测喉鳞癌淋巴结转移
Yun Liang,Min He,Wenqing Chen et al.
Yun Liang et al.
Background: Lymph node metastases (LNM) in laryngeal squamous cell carcinoma (LSCC) has been associated with lower survival, but current imaging methods, such as computed tomography (CT), have limited capabilities to iden...
Quality of life in patients with pan-cancer undergoing concurrent chemoradiotherapy: a bibliometric analysis (1995-2024) [0.03%]
泛癌患者同步放化疗的生活质量：1995-2024年文献计量分析
Ao Shen,Pan Fan,Dingrong Fan et al.
Ao Shen et al.
Background: Chemoradiotherapy is a therapeutic approach that prolongs survival but may simultaneously negatively affect the quality of life (QOL) of cancer patients. Current research on quality of life (QOL) in pan-cancer...
Comprehensive single-cell sequencing reveals the tumor microenvironment and tumor-specific characteristics in trachea squamous cell carcinoma [0.03%]
综合单细胞测序揭示了气管鳞状细胞癌的肿瘤微环境及肿瘤特异性特征
Hongwu Wang,Hongli Li,Heng Zou et al.
Hongwu Wang et al.
Trachea squamous cell carcinoma (TSCC) is a subtype of lung cancer. A thorough investigation of the tumor microenvironment of TSCC is crucial for the development of cancer therapeutics and predicting clinical responses. In this study, we ut...
Expression of immune checkpoints (IDO and PD-L1) in oral tongue cancer patients: a 10-year retrospective cohort study in Pakistan [0.03%]
巴基斯坦舌癌患者免疫检查点（IDO和PD-L1）的表达：一项为期10年的回顾队列研究
Merium Fatima,Shaarif Bashir,Syed Atif Raza et al.
Merium Fatima et al.
Background: Tongue squamous cell carcinoma (TSCC) is a significant global health issue with high incidence and mortality rates. Current treatments involve surgery, radiotherapy, and chemotherapy; however, prognosis remain...
Clinicopathologic characteristics and predictive nomogram of skip lymph node metastasis in gastric cancer [0.03%]
胃癌跳跃淋巴结转移的临床病理特征及预测模型
Xinwei Zhang,Yuwei Du,Yuegang Li et al.
Xinwei Zhang et al.
Background: Lymph node (LN) status is an independent factor affecting the prognosis of gastric cancer patients. Skip metastasis is a pattern of LN metastasis across a peritumoral (PT) area to an extra-peritumoral (EP) are...
The initiation of the second-step intradisciplinary tumor board discussion and its impact on treatment decision. Retrospective data analysis of 12 years' experience in a tertiary oncology center [0.03%]
第二阶段肿瘤多学科讨论的启动及其对治疗决策的影响：三级肿瘤中心12年经验的回顾性数据分析
László Csaba Mangel,Erika Kövér,Balázs Pécsi et al.
László Csaba Mangel et al.
Background: Multidisciplinary team (MDT) meetings are generally accepted forums for the quality of cancer care, however, there is an ongoing discussion about the substantial role of MDTs in reaching optimal treatment deci...
Adjuvant anti-PD-1 therapy improves melanoma-specific survival in stage IIIC-IV melanoma patients with high tumor mutation burden and BRAF V600 mutation [0.03%]
抗PD-1疗法可提高高肿瘤突变负荷和BRAF V600突变的IIIC-IV期黑色素瘤患者的无复发生存率
Julia Forschner,Julia Huynh,Christopher Schroeder et al.
Julia Forschner et al.
Immune checkpoint inhibitors (ICI) have significantly improved melanoma-specific survival (MSS), particularly in patients with tumors with a high tumor mutational burden (TMB) or BRAF mutation. In the adjuvant setting, ICIs significantly im...