Combined use of 3D-printed customized prostheses and denosumab for the treatment of giant cell tumor of the distal radius: clinical outcomes and efficacy [0.03%]
3D打印定制假体与地诺单抗联合治疗远端桡骨巨细胞瘤的临床疗效分析
Ye Li,Longqing Li,Xuanhong He et al.
Ye Li et al.
Objective: To investigate the short- and mid-term clinical efficacy of denosumab combined with 3D-printed prosthesis in the treatment of patients with giant cell tumor of the distal radius. ...
Development of a predictive model for metachronous liver metastasis in gastric cancer [0.03%]
胃癌肝转移的预测模型研究
Siyuan Wang,Gaozan Zheng,Fengsu Wu et al.
Siyuan Wang et al.
Background: Patients with metachronous liver metastasis (MLM) in gastric cancer generally have a poor prognosis. Early detection and accurate prediction of MLM are crucial for improving clinical outcomes. This study aims ...
A review of the participation of DDIT4 in the tumor immune microenvironment through inhibiting PI3K-Akt/mTOR pathway [0.03%]
DDIT4在肿瘤免疫微环境中的作用及其通过抑制PI3K-Akt/mTOR信号通路机制的回顾性研究分析
Yunshu Jiao,Yang Xiang
Yunshu Jiao
DDIT4 (DNA Damage Inducible Transcript 4), a well-established inhibitor of the PI3K-Akt/mTOR pathway, is upregulated under cellular stress conditions. Extensive research has demonstrated that DDIT4 expression is aberrantly elevated in vario...
Spatial gene expression profiling identifies prognostic features of residual tumors after neoadjuvant chemotherapy in triple-negative breast cancer [0.03%]
空间基因表达谱分析鉴定三阴性乳腺癌新辅助化疗后残留病灶的预后特征
Hye Sung Won,Yong-Seok Kim,Kyung Jin Seo et al.
Hye Sung Won et al.
Background: The standard treatment for early-stage triple-negative breast cancer (TNBC) is neoadjuvant chemotherapy (NAC) followed by surgery, but patients with residual disease have worse outcomes. We investigated geneti...
Network toxicological insights into DEHP exposure and thyroid cancer development and progression [0.03%]
基于网络毒理学的DEHP致甲状腺癌风险评估研究
Yuhang Zhang,Qiang Wang
Yuhang Zhang
This study aimed to identify markers of di-2-ethylhexyl phthalate (DEHP) exposure associated with thyroid cancer occurrence and prognosis by integrating network toxicology and molecular docking. Expression profiles and clinical information ...
The efficacy of trastuzumab deruxtecan in Chinese breast cancer patients: a real-world multicenter study [0.03%]
德曲珠利单抗治疗中国乳腺癌患者的真实世界多中心研究疗效分析
Miao He,Xiaohui Liu,Yan Zhang et al.
Miao He et al.
Introduction: In mainland China, trastuzumab deruxtecan was first authorized in February 2023 as a monotherapy for the treatment of patients with HER-2-positive adult breast cancer who were either unresectable or had meta...
Case Report: Dramatic response to entritinib in a patient with gastrointestinal stromal tumor positive for NTRK3 fusion [0.03%]
案例报告：恩特雷替尼治疗NTRK3融合阳性的胃肠道间质瘤患者的显著疗效
Guomin Dong,Pengyu Han,Zhiyun Zhang et al.
Guomin Dong et al.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, with proto-oncogene, receptor tyrosine kinase (c-kit), or PDGFRα mutations detected in around 85% of cases. GISTs without c-kit o...
From gut to proteomics: the impact of Roseburia intestinalis on post-translational modifications in colorectal cancer [0.03%]
从肠道到蛋白质组学：Roseburia intestinalis对结直肠癌中翻译后修饰的影响
Lu Li,Yong Zhang,Qianqian Wu et al.
Lu Li et al.
Background: Colorectal cancer (CRC) represents a significant global health challenge. Gut microbiota imbalance and abnormal chromatin modifications play critical roles in the progression of CRC. However, the mechanisms by...
Complete remission of recurrent gastric cancer in a young female patient through CLDN18.2-targeted therapy (LM302) and metastatic ovarian tumor resection: a case report of refractory disease overcoming chemotherapy and immunotherapy resistance [0.03%]
CLDN18.2靶向治疗（LM302）联合转移性卵巢肿瘤手术切除成功治愈年轻女性 recurrent胃癌病例：化疗和免疫治疗耐药的难治性疾病的克服报告
Muyang Chen,Tongshan Wang,Anpeng Wang et al.
Muyang Chen et al.
Young patients with recurrent, metastatic gastric cancer (GC) resistant to chemotherapy and immunotherapy have poor outcomes and limited treatment options. CLDN18.2 has emerged as a promising target in GC. We report the case of a 35-year-ol...
Physical activity in older cancer patients: evidence and clinical implications [0.03%]
老年癌症患者的体育活动：证据与临床意义
Shugo Yajima,Shin Kobayashi,Tadayoshi Hashimoto et al.
Shugo Yajima et al.
This mini-review examines the role of physical activity in older cancer patients based on current evidence. As cancer incidence increases with age, older patients face unique challenges including comorbidities and functional decline. This r...