Editorial: Microbial biomarkers predicting BCG therapy response in non-muscle invasive bladder cancer [0.03%]
述评：预测非肌层浸润性膀胱癌卡介苗治疗反应的微生物生物标志物
Guglielmo Mantica,Francesco Esperto,Rafaela Malinaric
Guglielmo Mantica
Cancer-associated adipocyte promote progression and immunosuppression in triple-negative breast cancer [0.03%]
癌症相关脂肪细胞促进三阴性乳腺癌的进展和免疫抑制
Xichao Zhang,Shenjie Zhong,Shan Liu et al.
Xichao Zhang et al.
Triple-negative breast cancer (TNBC) is characterized by highmetastatic potential and a lack of effective targeted therapies. Within the tumor microenvironment (TME) of TNBC, adipocyte can undergo transformation into cancer-associated adipo...
Navigating diagnostic dilemmas toward precision therapy: a case report and literature review on gastric metastasis from breast cancer [0.03%]
诊断迷局与精准治疗-1例乳腺癌胃转移病例报道及文献复习
Xiaoyu Zhang,Xiangwu Lin,Dunya Yang et al.
Xiaoyu Zhang et al.
Gastric metastasis from breast cancer (GMBC) is a rare but diagnostically challenging condition, whose clinical and imaging features often mimic primary gastric cancer or treatment-related adverse effects. This study integrates a detailed c...
MRI-derived tumor volume vs. pathological tumor diameter: a comparative study of prognostic value for disease-free survival in multifocal/multicentric breast cancer [0.03%]
基于磁共振成像的肿瘤体积与病理直径的比较研究及其对多灶性/多中心乳腺癌无病生存期预后的价值评估
Jiangni Song,Juan Mao,Nianyang Li et al.
Jiangni Song et al.
Background and objective: Multifocal/multicentric breast cancer (MMBC) is characterized by multiple tumor foci in the same breast, but conventional T staging based on the largest lesion (Dmax) may underestimate true tumor...
Cold-spot driven local failure after stereotactic body radiation therapy for colorectal liver metastases [0.03%]
立体放射治疗结直肠癌肝转移后的冷点驱动局部失败
Hyunju Shin,Jeong Il Yu,Hee Chul Park et al.
Hyunju Shin et al.
Background: This single-institution retrospective study investigated whether actual dosimetric plan quality metrics better predict freedom from local progression (FFLP) than nominal prescription dose after stereotactic bo...
Lisha Ren,Qianyong He,Weili Wu et al.
Lisha Ren et al.
Intracranial neuroendocrine carcinoma (NEC) is a highly uncommon malignancy, accounting for approximately 0.74% of cases. It is characterized by rapid infiltration and poor survival rates. This case report details a 51-year-old woman who pr...
STING agonism in brain tumours: mechanisms, challenges, and therapeutic advances [0.03%]
脑肿瘤中的STING激动剂：机制、挑战及治疗进展
Zeta Ioannou,Paul Cressey,Mohammed H Ahmed et al.
Zeta Ioannou et al.
High-grade gliomas, including diffuse midline glioma (DMG), remain some of the most aggressive and treatment-resistant brain tumours, largely due to their diffuse growth, inoperability, and profoundly immunosuppressive tumour microenvironme...
Case Report: PD-1/CTLA-4 dual checkpoint blockade(QL1706) in advanced pulmonary squamous cell carcinoma complicated by multidrug-resistant tuberculosis after multiple lines of immunotherapy [0.03%]
个例报道：多线免疫治疗后耐多药结核病患者的肺鳞癌PD-1/CTLA-4双检查点抑制剂（QL1706）治疗
Li Huang,Hao Li
Li Huang
Immune checkpoint inhibitors (ICIs) are standard care for advanced non-small cell lung cancer (NSCLC), yet patients with active tuberculosis (TB) are consistently excluded from clinical trials. Furthermore, data guiding the use of dual PD-1...
High-throughput screening to engineer optimal T cell therapies: current knowledge and future prospects [0.03%]
高通量筛选技术工程化最优T细胞疗法：现状与未来展望
Lei Liu,Saisai Chen,Meng Ding et al.
Lei Liu et al.
Adoptive T cell therapy (ACT) is a potent strategy in cancer immunotherapy, but its clinical efficacy is often limited by primary resistance. To overcome this challenge, high-throughput screening technologies have emerged as essential tools...
Research progress on early diagnostic biomarkers and liquid biopsy technologies for colorectal cancer: a comprehensive review [0.03%]
结直肠癌早期诊断生物标志物和液体活检技术研究进展：综述文章
He Shen,Zhonghao Wang,Wenjin Zhang
He Shen
Colorectal cancer (CRC) remains one of the most prevalent and lethal malignancies globally, with its prognosis heavily dependent on the stage at diagnosis. Early detection (stages 0-I) significantly improves 5-year survival rates to over 90...