Development of a high-grade glioma preclinical surgery model using an inducible KRAS/TP53 Oncopig [0.03%]
利用可诱导的KRAS/TP53癌猪开发高级别胶质瘤外科预临床模型
Caleb Y Kwon,Ryan B Duke,Augustino V Scorzo et al.
Caleb Y Kwon et al.
Introduction: Surgery remains the primary treatment modality for high-grade glioma; yet, Q10 median overall survival has seen only modest improvement over the past few decades. Lack of reliable preclinical models that rec...
Promising efficacy of teniposide in H3K27M mutant diffuse midline gliomas: a case report [0.03%]
替尼波苷治疗H3K27M突变弥漫性中线胶质瘤疗效观察：1例报告
Xiaoman Wang,Tingting Niu,Junxian Xia et al.
Xiaoman Wang et al.
Diffuse midline glioma with H3K27M mutation (H3K27M-mutant DMG) is a rare central nervous system tumor with an extremely poor prognosis. The absence of a standard treatment regimen makes achieving durable survival benefits a major therapeut...
Irini Yacoub,Joshua Khalil,Shouyi Wei et al.
Irini Yacoub et al.
Proton therapy (PT) is an advanced form of radiation therapy that exploits the physical properties of the Bragg peak to deliver highly conformal dose distributions while minimizing radiation exposure to surrounding normal tissues. This prec...
Endoscopic resection of adult sphenoid sinus myofibroma: a rare case report with narrative review [0.03%]
成人蝶窦肌纤维瘤内镜切除术：罕见病例报告及文献回顾
Chong Zhang,Zhipeng Wu,Bing Chen et al.
Chong Zhang et al.
This study documents an exceptionally rare instance of primary myofibroma originating in the sphenoid sinus of a 60-year-old female patient, who presented with acute progressive diplopia, ptosis, and headache. Preoperative imaging identifie...
Deep learning accurately and reliably segments pelvic vascular structure in CT scans of gynecologic cancer patients [0.03%]
深度学习准确而可靠地对妇科癌症患者的CT扫描中的盆腔血管结构进行分割
Hyeonseung Kim,Min Jin Jeong,Kyo Yeong Koo et al.
Hyeonseung Kim et al.
Introduction: Accurate identification of pelvic vascular structures is critical for safe and effective gynecologic cancer surgery, yet intraoperative recognition of the internal iliac artery, its branches, and correspondi...
Reclassifying contralateral axillary metastasis: survival benefit of aggressive local therapy challenges stage IV designation [0.03%]
同侧腋窝转移复发的再分类：积极局部治疗带来的生存益处对IV期定义提出了挑战
Shanqing Liu,Yong Li,Yan Shen et al.
Shanqing Liu et al.
Background: Contralateral axillary metastasis (CAM) is currently staged as M1 (stage IV) breast cancer, guiding treatment towards palliative systemic therapy. However, emerging evidence suggests CAM may behave as a locore...
Elevated FGR protein expression identifies a high-risk subset of diffuse large B-cell lymphoma and a potential therapeutic target [0.03%]
FGR蛋白高表达可识别弥漫性大B细胞淋巴瘤的高危亚型并作为潜在治疗靶点
Kexin Shen,Shiyu Jiang,Ailing Gui et al.
Kexin Shen et al.
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma, and despite effective first-line immunochemotherapy a substantial proportion of patients develop relapse/refractory (RR) disease, ...
Adult-onset primary hemophagocytic syndrome with concurrent Epstein-Barr virus infection: a case report with literature review [0.03%]
成人原发性噬血细胞综合征伴Epstein-Barr病毒感染的病例报告及文献回顾
Lei Huang,Shuli Guo
Lei Huang
Objective: To investigate the clinical and laboratory features, phenotypic characteristics, associated genes, and treatment strategies for adult primary hemophagocytic lymphohistiocytosis (HLH). ...
Failure identification of metastasis and non-sentinel lymph node metastasis in early gastric cancer [0.03%]
早期胃癌淋巴结转移及非SENTINEL淋巴结转移的失败识别率
Huiliang Zhang,Qingwen Huang,Jitao Du et al.
Huiliang Zhang et al.
Background: In the realm of sentinel lymph node navigation surgery for cancer patients, the intraoperative pathological examination of sentinel lymph nodes is of paramount importance in delineating the extent of surgical ...
Progression-free survival exceeding four years after transarterial embolization for liver metastases from triple-negative breast cancer: a case report [0.03%]
肝动脉化疗栓塞治疗三阴性乳腺癌肝转移的4年以上无进展生存：一例报告
Shengjie Liu,Mirinisa Kaicaier,Aisaide Aikelaimu et al.
Shengjie Liu et al.
Liver metastasis in triple-negative breast cancer (TNBC) is associated with an unfavorable prognosis. Prior studies have reported a median overall survival of approximately 3-15 months after the diagnosis of liver metastasis, with a 5-year ...