From trash to treasure: tumor draining lymph nodes as a multi-omics goldmine in cancer therapy [0.03%]
从废物到宝藏：肿瘤引流淋巴结在癌症治疗中的多组学金矿属性
Yina Li,Zihan Chen,Zhikun Guo et al.
Yina Li et al.
Tumor draining lymph nodes (TDLNs), as secondary lymphoid organs, are pivotal in initiating and regulating adaptive immune responses. Historically, TDLNs were recognized primarily as metastasis gateways in cancer, promoting radical dissecti...
SPINK1 facilitates tumor progression via the EGFR/JAK/STAT3 axis in oral squamous cell carcinoma: insights from single-cell RNA sequencing [0.03%]
SPINK1通过EGFR/JAK/STAT3轴促进口腔鳞状细胞癌肿瘤进展：来自单细胞RNA测序的见解
Mingyan Bao,Zhangui Tang
Mingyan Bao
Objective: This study aimed to elucidate the functional role and molecular mechanisms of Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) in oral squamous cell carcinoma (OSCC) through integrative analysis of single-cell ...
Cardiac tamponade as a rare presentation of Hodgkin's lymphoma: a case report [0.03%]
心脏压塞作为霍奇金淋巴瘤罕见表现的一例报告
Piotr Limanówka,Matylda Kujawińska,Anna Kaput et al.
Piotr Limanówka et al.
Hodgkin's lymphoma usually manifests with symptoms such as enlarged peripheral lymph nodes, fever, night sweats, and weight loss. It's the third most common pediatric cancer and includes two main types. Here, we describe a case of a 17-year...
Real-world Australian experience with tisagenlecleucel for relapsed/refractory diffuse large B-cell lymphoma-importance of pre-CAR-T optimization [0.03%]
Tisagenlecleucel治疗复发/难治性弥漫大B细胞淋巴瘤的澳大利亚真实世界经验- CAR-T治疗前优化的重要性
Phoebe Joy Ho,Vinay Vanguru,Cale S Burge et al.
Phoebe Joy Ho et al.
Introduction: Up to 50% of patients with diffuse large B-cell lymphoma (DLBCL) relapse or are refractory to first-line therapy. Tisagenlecleucel, a CD19-directed chimeric antigen receptor (CAR)-T cell therapy, is approved...
Artificial intelligence in advanced gastric cancer: a comprehensive review of applications in precision oncology [0.03%]
人工智能在晚期胃癌中的应用：精准肿瘤学的全面回顾
Min Fu,Jialing Xu,Yingying Lv et al.
Min Fu et al.
Gastric cancer (GC) remains a major global health challenge, particularly in its advanced stages where prognosis is poor, and treatment responses are heterogeneous. Precision oncology aims to tailor therapies, but current biomarkers have li...
Vestibular schwannomas and papilledema without hydrocephalus: a case report [0.03%]
有关前庭神经鞘瘤和视盘水肿(无脑积水)的病例报告
Roberto Calderón-Moreno,Noé Pérez Carrillo,José de Jesús Martínez-Manrique
Roberto Calderón-Moreno
Vestibular Schwannomas are frequent tumors of the cerebellopontine angle, classically presenting with cochlear and facial nerve alteration. They tend to have histopathological and intratumoral degeneration seen on MRI, and can cause CSF obs...
Combined treatment with CDK4/6, CDK2, and CXCR1/2 inhibitors effectively halts the growth of BRAF wild-type melanoma tumors [0.03%]
CDK4/6、CDK2和CXCR1/2抑制剂联合治疗可有效阻止野生型BRAF黑色素瘤肿瘤生长
Jinming Yang,Weifeng Luo,Patricia Ward et al.
Jinming Yang et al.
Introduction: Inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6) are approved for the treatment of locally advanced or metastatic breast cancer, but not for melanoma. ...
Comparative study of National Institute of Health criteria and TNM staging system in predicting the prognosis of gastrointestinal stromal tumours: a retrospective study [0.03%]
一项回顾性研究：美国国立卫生研究院标准和TNM分期系统在预测胃肠道间质瘤预后方面孰优孰劣的比较研究
Jin-Hu Chen,Zhen-Rong Yang,Zhi-Ming Cai et al.
Jin-Hu Chen et al.
Background: In 2009, the American Joint Commission on Cancer incorporated the gastrointestinal stromal tumours (GISTs) risk classification into the tumour, node, metastasis (TNM) staging system. We aimed to evaluate the p...
Case report: Primary giant osteosarcoma of the heart protruding into the pericardial space in a young woman: a case of multimodal imaging [0.03%]
病例报告：年轻女性心脏原发性巨大骨肉瘤突入心包腔一例——多模式影像学表现
Ling Zhao,Fei Li,Wenzhe Xu et al.
Ling Zhao et al.
Background: Primary cardiac malignancies are rare, and primary cardiac osteosarcoma is even rarer. The prognosis is poor. Four multimodality imaging data of the same case have not been retrieved yet. ...
Case Report: Sequential PTCD and biliary seed stent combined with targeted-immunotherapy for advanced pancreatic cancer with malignant obstructive jaundice: a multidisciplinary approach [0.03%]
个例报告：晚期胰腺癌恶性阻塞性黄疸经皮肝穿胆管引流联合胆道内支架置入序贯靶向-免疫治疗的多学科协作模式探究
Weijun Li,Guoyang Sun,Rui Zhu et al.
Weijun Li et al.
Malignant obstructive jaundice (MOJ) due to tumor compression or invasion of the bile duct carries a grave prognosis. We report a case of a 54-year-old female patient (height: 160 cm, weight: 55 kg, BMI: 21.5 kg/m², ECOG performance status...