Machine learning-based differentiation of lung squamous cell carcinoma and adenocarcinoma using clinical-semantic and radiomic features [0.03%]
基于机器学习的肺鳞癌和腺癌分类：使用临床语义及影像组学特征的方法研究
Yanju Li,Xiaomeng Yang,Yingjin Zhang et al.
Yanju Li et al.
Purpose: To evaluate and compare the predictive performance of machine learning methods using clinical-semantic, radiomic, and combined features in distinguishing squamous cell carcinoma (SCC) from adenocarcinoma (ADC) in...
APOL1 is a novel prognostic biomarker in thyroid cancer and correlates with immune infiltration [0.03%]
APOL1是甲状腺癌的新型预后生物标志物并与免疫浸润相关
Jianting Man,Xingru Tao,Zongyuan Zhang et al.
Jianting Man et al.
Background: Although apolipoprotein 1 (APOL1) expression is upregulated in several types of cancers, including thyroid cancer (THCA), its specific role in THCA remains unclear. The aim of the present study was to analyze ...
Long-term outcomes and patterns of failure after empiric SBRT for presumed early-stage lung tumors [0.03%]
基于经验的立体定向体放射治疗假定为早期肺癌患者的长期疗效及失败模式分析
Karim El-Marouk,Esra Degerli,Lukas Käsmann et al.
Karim El-Marouk et al.
Background: Stereotactic body radiation therapy (SBRT) is the established standard of care for medically inoperable early-stage non-small cell lung cancer (ES-NSCLC). When a biopsy is unfeasible, it is often delivered emp...
Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/ MDA5 expression and interferon signaling in lung cancers harboring KEAP1/ STK11 mutations [0.03%]
KEAP1/STK11突变的肺癌中，红氧表型通过抑制STING/MDA5表达和I型干扰素信号传导促进免疫治疗抗性及T细胞排除微环境
Ashish Shrestha,Yangchan Li,Lixia Huang et al.
Ashish Shrestha et al.
Background: KEAP1 and STK11 are frequently mutated in NSCLC, and are associated with compromised response to immunotherapy, the underlying mechanism of which is not fully understood. ...
Case Report: Genomic characterization of a rare skull-base plasmacytoma [0.03%]
病例报告：罕见颅底浆细胞瘤的基因组特征分析
Hasan Alanya,Sreekar Kasturi,Kanat Yalcin et al.
Hasan Alanya et al.
Skull-base plasmacytoma (SBP) is a rare plasma cell neoplasm that typically presents as a slow-growing skull-base lesion in older adults; however, its molecular underpinnings are poorly characterized, limiting targeted therapeutic intervent...
Toripalimab plus gemcitabine and cisplatin induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: a retrospective study [0.03%]
特瑞普利单抗联合吉西他滨和顺铂诱导化疗治疗局部区域晚期鼻咽癌的疗效：一项回顾性研究
Renba Liang,Ling Lei,Xinxiao Li et al.
Renba Liang et al.
Objective: To explore the efficacy and safety of toripalimab combined with gemcitabine and cisplatin (GP) induction chemotherapy and sequential concurrent chemoradiotherapy in LANPC treatment. ...
Establishment of a CT-based radiomic feature robustness databank for OPC patients via image perturbation in a multi-institutional study: a practical method to safeguard model generalizability [0.03%]
基于多中心研究中通过图像干扰建立OPC患者CT影像组学特征稳健性数据库：一种实用的保护模型泛化能力的方法
Yongqiang Wang,Alex Zwanenburg,Jiang Zhang et al.
Yongqiang Wang et al.
Purpose: To guide the preselection of highly repeatable radiomic features (RFs) in downstream analysis without further analysis its repeatability, a detailed radiomic feature robustness databank (RF-RobustDB) was establis...
Caprine herpes virus-1 reduces cell viability and enhances chemosensitivity in breast cancer cells [0.03%]
山羊疱疹病毒1型降低乳腺癌细胞活力并增强其化疗敏感性
C A Iannuzzi,F Pagano,M Tomeo et al.
C A Iannuzzi et al.
Introduction: Oncolytic viruses (OVs) are promising therapeutic agents in oncology that directly lyse tumor cells, modulate the immune response, and alter the tumor microenvironment. Non-human OVs offer advantages over th...
The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-κB pathway [0.03%]
D-2-羟基戊二酸通过FTO/NF-κB信号抑制小胶质细胞激活
Lu Wang,Huiting Zhang,Xifeng Jing et al.
Lu Wang et al.
Introduction: Mutations in isocitrate dehydrogenase 1 (mIDH1) generate the oncometabolite (R)-2-hydroxyglutarate (R-2HG), which promotes tumorigenesis by inhibiting α-ketoglutarate-dependent enzymes and altering the epig...
PARP inhibitors as radiosensitizers: a comprehensive review of preclinical evidence and clinical applications [0.03%]
PARP抑制剂作为放射增敏剂：前期临床证据和临床应用的全面回顾
Xiaodong Luo,Shuo Gao,Kaiyang Sun et al.
Xiaodong Luo et al.
Poly (ADP ribose) polymerase 1 (PARP1) plays a central role in the response of DNA damage induced by tumor radiotherapy. This paper systematically reviewed the structural and functional characteristics of PARP1 and its molecular mechanism i...