The tricky effects of TROP2 in lung cancer: from clinical practice back to fundamental investigations [0.03%]
TROP2在肺癌中的复杂作用：从临床实践到基础研究的探索
Renwang Liu,Mingbiao Li,Penghu Gao et al.
Renwang Liu et al.
TROP2, a transmembrane glycoprotein, is overexpressed and plays pivotal roles in diverse epithelial tumors. The differential expression of TROP2 between cancer and normal tissues offers distinct advantages in developing drugs targeting it. ...
Hypoxia promotes pancreatic adenocarcinoma progression by stabilizing ID1 via TRIM21 suppression [0.03%]
缺氧通过TRIM21抑制稳定ID1促进胰腺导管腺癌进展
Rui Cheng,Yuanjun Tang,Xuedi Cao et al.
Rui Cheng et al.
Introduction: Pancreatic adenocarcinoma (PAAD) is a highly aggressive malignancy characterized by a profoundly hypoxic tumor microenvironment, which fosters tumor progression and confers resistance to therapy The oncogeni...
Burden of malignant neoplasm of bone and articular cartilage from 1990 to 2021 and its predictions to 2030 in China compared with world [0.03%]
1990至2021年中国骨和关节软骨恶性肿瘤疾病负担及2030年预测：与中国以外世界地区的比较研究
Cheng Chen,Xu Zheng,Yi Zhang et al.
Cheng Chen et al.
Objective: To comprehensively examine the incidence and mortality of malignant neoplasms of bone and articular cartilage (MNBAC) in China compared with the world, as well as its age-specific patterns and sex disparities. ...
Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit TET2 mutations [0.03%]
与TET2多突变相关的原漆相关家族性慢性粒单细胞白血病
Yang Zhang,Yujiao Luo,Hongling Peng et al.
Yang Zhang et al.
Background: To explore the potential association between long-term exposure to raw lacquer and the development of chronic myelomonocytic leukemia (CMML). ...
HIV-associated gut dysbiosis drives oncogenesis through metabolic-immune crosstalk: mechanisms and therapeutic implications [0.03%]
艾滋病相关的肠道菌群失调通过代谢免疫相互作用驱动肿瘤发生：机制和治疗意义
Qingquan Meng,Liran Xu,Furong Xu et al.
Qingquan Meng et al.
HIV-induced gut microbiota dysbiosis perpetuates mucosal barrier disruption and systemic inflammation despite antiretroviral therapy (ART), creating a tumor-permissive microenvironment. This review synthesizes evidence linking HIV-associate...
Ginsenoside Rh2 repressed the progression of prostate cancer through the mitochondrial damage induced by mitophagy and ferroptosis [0.03%]
人参皂苷Rh2通过线粒体自噬和铁死亡诱导的线粒体损伤抑制前列腺癌的发展
Zhen He,Jianxi Shi,Bing Zhu et al.
Zhen He et al.
Introduction: Prostate cancer (PC), the most common male genitourinary malignancy and second leading cause of global cancer deaths in men, frequently progresses to lethal castration-resistant PC (CRPC). Ginsenoside Rh2 (G...
A high stroma-tumor ratio is associated with an immunosuppressive tumor microenvironment and a poor prognosis in bladder cancer [0.03%]
基底膜高肿瘤比与膀胱癌免疫抑制性肿瘤微环境及不良预后相关
Yiqiang Da,Zirong Lu,Zijian Zhu et al.
Yiqiang Da et al.
Purpose: Bladder cancer (BLCA) is one of the most common urogenital malignancies in the world. The stroma of the tumor microenvironment (TME) largely affects the progression of BLCA. However, a stroma-relevant biomarker f...
Clinicopathological features, risk model and prognosis of 115 cases of epithelioid hemangioendothelioma: A single-center study [0.03%]
115例上皮样血管内皮细胞瘤的临床病理特征、风险模型及预后分析：单中心研究
Shihui Zhang,Yiting Liang,Ye Yang et al.
Shihui Zhang et al.
Objective: To investigate the clinicopathological features, diagnostic value, risk model and prognostic significance of epithelioid hemangioendothelioma (EHE) in a retrospective cohort of 115 cases. ...
Evaluating lung cancer screening disparities in an integrated healthcare system: barriers and opportunities [0.03%]
评估整合医疗体系中肺癌筛查的差异性：障碍和机会
Carmen Javier,Sheng-Fang Jiang,Jenna Philippe et al.
Carmen Javier et al.
Rationale: The national average rate of lung cancer screening (LCS) has remained low at roughly 6%, with California's rate among the lowest at 1% compared to all fifty states. ...
Diagnosis methods for pancreatic cancer with the technique of deep learning: a review and a meta-analysis [0.03%]
基于深度学习的胰腺癌诊断方法研究：综述与元分析
Yuanbo Bi,Dongrui Li,Ruochen Pang et al.
Yuanbo Bi et al.
Background: Early diagnosis can significantly improve survival rate of Pancreatic ductal adenocarcinoma (PDAC), but due to the insidious and non-specific early symptoms, most patients are not suitable for surgery when dia...