First-line therapies for unresectable hepatocellular carcinoma: a network meta-analysis of immune checkpoint inhibitors and transarterial therapies based on 35 randomized trials [0.03%]
不可切除肝细胞癌一线治疗的网络meta分析：基于35项随机对照试验的免疫检查点抑制剂与经导管动脉疗法的比较研究
Huanghui Zhang,Shenyao Zhou,Jiaxin Dai et al.
Huanghui Zhang et al.
Objective: Unresectable hepatocellular carcinoma (uHCC) is a major global health challenge. Current first-line strategies involve immune checkpoint inhibitors (ICIs), transarterial therapies, and anti-VEGF agents. However...
Targeting TGF-β-driven fibrotic, epigenetic remodeling and Bax/Bcl-2 through polyphenol-exercise synergy: molecular implications for biomechanical impairment and rehabilitation in cancer [0.03%]
靶向转化生长因子-β驱动的纤维化、表观遗传重编程和Bax/Bcl-2：多酚-运动协同作用对癌症生物力学障碍和康复的分子影响
Lin Liu
Lin Liu
Optimizing human activity through biomechanical efficiency is central not only to enhancing physical performance but also to restoring functional capacity in disease states. In cancer patients, tumor progression and treatment-related toxici...
Spatially programmed Fe and Pt electrode-driven electrochemistry reconditions the tumor microenvironment and sensitizes triple-negative breast cancer to PD-1 Blockade [0.03%]
空间编程的Fe和Pt电极驱动的电化学疗法可调节肿瘤微环境并使三阴性乳腺癌对PD-1阻断敏感化治疗
Jia Qin,Yi He,Yueyao Yang et al.
Jia Qin et al.
Excess extracellular acidity is a defining barrier to effective antitumor immunity in solid tumors. Systemic buffers only partially correct tumor acidity and seldom rescue suppressed effector immunity. Here, we developed a spatially program...
Intra- and peritumoral radiomics for predicting equivocal HER2 status of breast cancer on contrast-enhanced mammography [0.03%]
对比增强乳腺摄影中用于预测乳腺癌HER2阴性变异的瘤内和瘤周影像组学标志物研究
Cong Xu,Juan Qiu,Shijie Zhang et al.
Cong Xu et al.
Objective: Identification of Human epidermal growth factor receptor 2 (HER2) status is significant for the treatment and prognosis of breast cancer patients. The study aimed to evaluate the equivocal HER2 (IHC 2+) status ...
Screening, validation, and mechanism study of antitumor components from Dioscorea nipponica Makino subsp. rosthornii based on spectrum-effect relationship analysis [0.03%]
基于谱效关系分析的薯蓣nipponensis var.rosthornii抗肿瘤成分的筛选、确证及机制研究
Mengjia Liang,Moyu Shen,Yuxuan Wang et al.
Mengjia Liang et al.
Objectives: This study aimed to screen potential antitumor compounds from Dioscorea nipponica Makino subsp. rosthornii, validate them in cellular models, and investigate their mechanisms underlying the inhibition of proli...
Epigenetic alterations in cancer metastasis: molecular mechanisms and implications for precision oncology [0.03%]
癌症转移中的表观遗传改变：分子机制及精准肿瘤学意义
Seval Turna,Semra Demokan
Seval Turna
Metastasis is a complex, multistep process that underlies the majority of cancer-related deaths and is increasingly recognized as a consequence of dynamic epigenetic reprogramming rather than solely genetic alterations. Epigenetic mechanism...
Preventive effect of transcutaneous electrical acupoint stimulation pretreatment on lymphedema in patients undergoing axillary lymph node dissection for breast cancer: a randomized controlled trial protocol [0.03%]
电针预处理预防乳腺癌腋窝淋巴结清扫术后淋巴水肿的随机对照试验方案研究报告
Linna Wu,Qing Mao,Zhu Zhu et al.
Linna Wu et al.
Introduction: Breast cancer-related lymphedema (BCRL) is a serious and intractable complication that severely affects the quality of life and survival rates of cancer patients. Transcutaneous electrical acupoint stimulati...
Case Report: Gastrointestinal cancer initially presenting as postmenopausal osteoporosis [0.03%]
个例报道：以绝经后骨质疏松症表现的胃肠道癌症
Jingyuan Li,Tian Liu,Ying Chen et al.
Jingyuan Li et al.
Background: Gastric cancer usually presents late with nonspecific symptoms such as epigastric discomfort, anorexia, weight loss, nausea, anemia, or gastrointestinal bleeding. Initial presentation with osteoporosis-like ma...
Burden of liver cancer from 1990 to 2021 and modelled projection to 2040: insights from the global burden of disease study 2021 [0.03%]
1990年至2021年全球肝癌疾病负担及2040年预测：基于全球疾病负担研究（GBD）2021的见解
Yong Xie,Tianshi Lyu,Haitao Guan et al.
Yong Xie et al.
Background: Liver cancer is a significant public health threat worldwide, yet data on its burden and trends are limited. This study aims to evaluate the global burden of liver cancer among global populations from 1990 to ...
Ultrasound-based radiomics and habitat analysis for noninvasive assessment of Ki-67 overexpression in breast cancer [0.03%]
基于超声的影像组学和栖息地分析在乳腺癌非侵入性评估Ki-67高表达中的应用研究
Li Zhu,Shanni Dong,Xushuang Qin et al.
Li Zhu et al.
Background: Accurate preoperative assessment of Ki-67 proliferation index remains a clinical challenge in breast cancer management. Conventional ultrasound radiomics often fails to fully capture intratumoral heterogeneity...