Lung cancer screening with AI can discover cures for many early diseases. A public utility can make sure it happens [0.03%]
人工智能肺癌筛查或可发现许多早期疾病的疗法 公共事业体系能确保其发生
James L Mulshine,Bruce S Pyenson
James L Mulshine
Many nations around the world are now implementing CT-based lung cancer screening. Growing evidence led the United States to require insurance coverage for LCS in high-risk individuals. Current CT scanners can obtain vast amounts of anatomi...
Dual-optimization hypothesis: integrating radiation dosimetry and mechanical reinforcement in radioactive seed implantation for lumbar metastases [0.03%]
双重优化假说：放射性种子植入治疗腰椎转移瘤的辐射剂量学与机械增强集成方法
Zhi-Qian Sun,Lu-Lu Du,Shuai Li et al.
Zhi-Qian Sun et al.
Objective: To explain the rapid pain relief observed hours after radioactive seed implantation for lumbar metastases (which precedes radiobiological effects) and propose a novel therapeutic framework that integrates two c...
Combination of locoregional and systemic therapy for hepatocellular carcinoma with portal vein tumor thrombus: a real-world retrospective study [0.03%]
门静脉瘤栓肝细胞癌的局部和系统综合治疗：真实世界回顾性研究
Xunbo Hou,Linan Yin,RuiBao Liu et al.
Xunbo Hou et al.
Background: The optimal treatment strategy for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) remains undefined. Although combinations of locoregional therapies-such as transarterial chem...
Case Report: From multiple myeloma to plasmablastic lymphoma - a diagnostic dilemma in unraveling a rare transformation [0.03%]
个例报告：从多发性骨髓瘤到浆细胞淋巴瘤——罕见转化病例的诊断困境
Mohamad Shraim,Ahmad Salameh,Akram Karama et al.
Mohamad Shraim et al.
Introduction: Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma. Its transformation from multiple myeloma (MM) is an exceptionally rare event, with only nine cases reported in ...
Phase I study of niraparib with radiotherapy for treatment of metastatic and locally advanced invasive carcinoma of the cervix (NIVIX) [0.03%]
用于治疗转移性及局部晚期侵袭性宫颈癌的尼拉帕利联合放疗I期研究(NIVIX)
Piyush Pathak,Eunji Jo,Susan Hilsenbeck et al.
Piyush Pathak et al.
Introduction: This Phase I study evaluated the safety and tolerability of concurrent niraparib, an oral poly(ADP-ribose) polymerase (PARP) 1/2 inhibitor, with definitive radiotherapy in women with locally advanced or plat...
Case Report: Immune checkpoint inhibitor-triggered anti-Ma2 paraneoplastic encephalitis in sarcomatoid pleural mesothelioma: a fatal case [0.03%]
个例报告：免疫检查点抑制剂触发的抗-Ma2副肿瘤性脑炎（伴肉瘤样胸膜间皮瘤）——一例致死病例
Ilker Nihat Okten,Tuba Baydaş
Ilker Nihat Okten
Background: Neurological immune-related adverse events (N-irAEs) represent rare but potentially fatal complications of immune checkpoint inhibitor (ICI) therapy. Among these, encephalitis associated with paraneoplatic neu...
Modulating efferocytosis in the intestinal epithelial cells during colorectal cancer [0.03%]
肠上皮细胞在结直肠癌中的凋亡调节作用
Laura Boeckaerts,Tania Løve Aaes,Evi Scheirlinckx et al.
Laura Boeckaerts et al.
Introduction: Colorectal cancer (CRC) is the thirdmost common cancer and a leading cause of cancer deaths worldwide, with over 1.9 million cases diagnosed in 2022. Due to poor response to classical cancer treatments, CRC ...
Targeting TLK2 with antisense oligonucleotides as a new strategy in acute myeloid leukemia [0.03%]
靶向TLK2的反义寡核苷酸在急性髓系白血病治疗中的新策略
Hsin-Yun Lin,Sokchea Khou,Evan Lind et al.
Hsin-Yun Lin et al.
Introduction: Tousled-like kinase 2 (TLK2) is a serine/threonine kinase that plays a role in DNA replication, chromatin remodeling, and DNA damage response. TLK2 has been implicated in the pathogenesis of various types of...
A dynamic nomogram for predicting axillary pathological complete response and its prognostic value in HER2-positive breast cancer [0.03%]
HER2阳性乳腺癌腋窝病理学完全缓解的动态诺模图及其预测价值
Xiaona Liu,Xiaoqian Li,Pan Liu et al.
Xiaona Liu et al.
Background: Accurate preoperative prediction of axillary pathological complete response (apCR) following neoadjuvant therapy (NAT) is crucial for de-escalating axillary surgery in breast cancer (BC) patients. This study a...
Efficacy of traditional Chinese medicine combined with chemotherapy for gastric cancer and precancerous gastric lesions: a systematic review and meta-analysis [0.03%]
中医药联合化疗治疗胃癌及前驱病变的疗效评价：系统综述和.meta.分析
Xiao Liang,Liu Yang,Shuaiqi Yuan et al.
Xiao Liang et al.
Background: Despite the advancements in therapeutic regimens, gastric cancer is still among the most concerning cancer-related public health problems. In previous literature, Traditional Chinese Medicine (TCM) proved to b...