Philemon N Ubanako,Ekene E Nweke,Zanele Nsingwane et al.
Philemon N Ubanako et al.
Retinoblastoma binding protein 6 (RBBP6) is a 200 kDa E3 ubiquitin ligase that performs several biological functions and plays a role in tumorigenesis. RBBP6 is overexpressed in several types of tumors, including lung, colorectal, breast, c...
A case report of bevacizumab-induced subcapsular renal hemorrhage in a patient with lung adenocarcinoma [0.03%]
一例贝伐单抗致肺腺癌患者肾下极出血的病例报告
Yue Du,Han Yu,Fei-Yan Zhou et al.
Yue Du et al.
This article reports a case of bilateral renal subcapsular hemorrhage in a 51-year-old female patient with lung adenocarcinoma and multiple metastases after receiving four cycles of combination antitumor therapy with pemetrexed, carboplatin...
Integrated tumor and germline profiling of lynch syndrome in a North Indian cohort [0.03%]
Lynch 综合征北印度人群的肿瘤和种系谱型分析
Himanshi Diwan,Anurag Mehta,Saudamini Sharma et al.
Himanshi Diwan et al.
Background: Lynch syndrome is the leading hereditary cause of colorectal and endometrial cancers, but data on germline mutations in the Indian population are insufficient. This study assessed patients with Lynch syndrome-...
A landscape analysis of clinical trials in cancer pain management: current trends and emerging therapeutic targets [0.03%]
癌症疼痛管理临床试验的景观分析：当前趋势和新兴治疗靶点
Jiaqi Cao,Xiaoyi Yu,Wei Lu
Jiaqi Cao
Background: Despite a growing volume of clinical research, cancer pain management remains dependent on opioid-centric paradigms with few therapeutic breakthroughs. To identify innovation gaps and guide future research, a ...
Prognostic heterogeneity in ASXL1-mutated AML and refinement by an immunophenotype-based score [0.03%]
ASXL1突变型急性髓系白血病的预后异质性及其免疫表型评分的校正
Yaming Zhang,Min Zhang,Yali Huang et al.
Yaming Zhang et al.
Introduction: ASXL1 is a frequently mutated gene in acute myeloid leukemia (AML) and is clinically recognized as an adverse prognostic marker, yet its clinical impact remains markedly heterogeneous. ...
Case Report: Borderline type I/II cryoglobulinemia associated with marginal zone lymphoma: a diagnostic challenge [0.03%]
病例报告：边缘区淋巴瘤相关的I/II型临界型冷球蛋白血症的诊断挑战
Fabiana Crispo,Giovanna Mansueto,Francesca Pia Scioscia et al.
Fabiana Crispo et al.
Cryoglobulinemia comprises heterogeneous disorders caused by immunoglobulins that precipitate at low temperatures, leading to vascular occlusion and immune-mediated tissue injury. Type I disease is typically linked to monoclonal gammopathie...
Comprehensive overview of management and risk assessment of breast cancer-related lymphedema: a multidisciplinary approach [0.03%]
全面概述乳腺癌相关淋巴水肿的管理与风险评估：多学科方法
Elisheva Knopf,Lily T Childers,Mackenzie Woodward et al.
Elisheva Knopf et al.
Breast cancer is one of the most commonly diagnosed cancers worldwide, with a particularly high incidence in women. Although many are cured of their malignancy, treatment options can present with significant long-term complications for the ...
Morphologic mimicry in high-grade lung carcinoma: a case report of RB1-intact, MYC-amplified, and NFE2L2-mutated pseudo-small cell lung cancer [0.03%]
高级别肺癌中的形态拟态：报告一例RB1基因稳定、MYC基因扩增和NFE2L2基因突变的假小细胞肺癌病例
Furong Wang,Yaxian Yang,Zhijian Luo et al.
Furong Wang et al.
Small cell lung cancer (SCLC) is historically defined by distinct neuroendocrine morphology and the obligate bi-allelic inactivation of TP53 and RB1. However, the advent of comprehensive molecular profiling has revealed a subset of high-gra...
Spatial patterns, temporal trends, and age-period-cohort effects of colon cancer incidence in Kazakhstan, 2005-2024 [0.03%]
哈萨克斯坦2005-2024年结直肠癌发病率的空间模式、时间趋势及年龄-时期-同辈效应
Gulnur Igissinova,Nurbek Igissin,Askhat Axarin et al.
Gulnur Igissinova et al.
Background: Colon cancer incidence is increasing globally, yet its spatial and temporal dynamics in Central Asia remain insufficiently studied. This study aimed to assess regional disparities and temporal trends of colon ...
Ying Yu,Xiangqian Nie
Ying Yu
Primary melanoma of the bladder is an extremely rare malignant tumor. In recent years, only a few sporadic cases have been reported. We report a 59-year-old male patient who presented with gross hematuria and had bladder irritation symptoms...