Clinical outcome of 115 patients with synchronous bilateral Wilms' tumor: largest cohort of single-center experience [0.03%]
同期双侧肾母细胞瘤115例临床预后分析：单中心最大宗病例报道
Hosam Y Asfour,Wael Zekri,M Hany Hussein et al.
Hosam Y Asfour et al.
Introduction: Bilateral Wilms' tumor (BWT) represents 5 - 8% of patients with Wilms' tumor (WT). Despite the improvement of WT survival, still patients with BWT are challenging with a high risk of relapse and renal failur...
Experimental study on the treatment of norepinephrine transporter-overexpressing pheochromocytomas and paragangliomas: a synthetic lethality strategy combining 131I-MIBG with PARP inhibitors [0.03%]
肾上腺素能转运蛋白过表达型嗜铬细胞瘤及副神经节瘤的实验治疗研究：结合131I-MIBG与PARP抑制剂的合成致死策略
Jieping Song,Lulu Zhang,Fan Qiu et al.
Jieping Song et al.
Introduction: Pheochromocytomas and paragangliomas (PPGLs) are associated with poor prognosis especially in patients with metastatic spread. This study aims to investigate the therapeutic potential of 131I-MIBG and the PA...
Real-world efficacy and safety of PD-1 inhibitors in patients with advanced esophageal squamous cell carcinoma: a single-center retrospective analysis [0.03%]
抗PD-1抑制剂治疗晚期食管鳞癌真实世界疗效和安全性研究：一项单中心回顾性分析
Xin Wang,Lili Jia,Yijian Zhao et al.
Xin Wang et al.
Background: Esophageal squamous cell carcinoma (ESCC) is associated with high mortality and limited treatment options. While PD-1/PD-L1-targeted immunotherapy has shown promise, clinical trial results may not fully repres...
3D-printed PEEK versus conventional free fibula flap for jaw reconstruction: a comparative clinical study [0.03%]
基于3D打印的peek材料与常规游离腓骨肌皮瓣下颌重建术的临床比较研究
Dongdong Feng,Yuxiang Zhang,Haiwei Guo et al.
Dongdong Feng et al.
Purpose: Aimed to evaluate the application value of polyether ether ketone (PEEK) based on three-dimensional (3D) printing technology for jaw reconstruction. ...
High BMI-attributable female-specific cancers: a comprehensive analysis of the global disease burden and trends from 1990 to 2021 and projections to 2040 [0.03%]
高体重指数（BMI）相关女性特有癌症的全球疾病负担及趋势：1990至2021年的全面分析以及2040年预测
Guangming Sun,Junmei Tang,Hao Chen et al.
Guangming Sun et al.
Background: High body mass index (BMI) is a key modifiable risk factor for breast, ovarian, and uterine cancer. Despite the ongoing global obesity epidemic, a systematic assessment of the long-term burden trends and dispa...
Use of imiquimod topical therapy for management of malignant melanoma positive margins [0.03%]
咪喹莫德外用治疗恶性黑色素瘤阳性切缘的观察研究
Katelyn Lewis,Sara Islam,David P Alper et al.
Katelyn Lewis et al.
Introduction: The treatment of positive margins following primary resection of cutaneous melanoma remains controversial with the current standard of care being repeat surgical resection. 5% topical imiquimod therapy has b...
Navigating the risks: a systematic review of immune checkpoint inhibitor therapy before liver transplant for hepatocellular carcinoma and its impact on allograft rejection and survival outcomes [0.03%]
免疫检查点抑制剂在肝癌患者肝脏移植术前的应用及其对移植物排斥和生存率影响的系统性回顾分析
Donghua Liu,Xinyi Wang,Xuelian Liu et al.
Donghua Liu et al.
Background: The administration of immune checkpoint inhibitors (ICIs) prior to liver transplantation (LT) for hepatocellular carcinoma (HCC) has been reported. Several studies suggest that ICIs may elevate the risk of all...
Progress of long-chain noncoding small nucleolar RNA host genes in thyroid cancer [0.03%]
长链非编码小核仁RNA宿主基因在甲状腺癌中的进展研究
Tingyu Yang,Yuanxu Xie
Tingyu Yang
Small nucleolar RNA host genes (SNHGs) are a class of long non-coding RNAs that are widely aberrantly expressed in thyroid cancer and regulate tumor progression through the "SNHG-miRNA-signaling pathway" network. SNHG7 promotes cell prolife...
Prognostic impact of CT-derived muscle-adipose index change in patients with inoperable esophageal squamous cell carcinoma undergoing chemoradiotherapy [0.03%]
基于CT的肌肉-脂肪指数变化对不可手术食管鳞癌患者同期放化疗预后的影响研究
Bingyi Zhang,Dong Guo,Yuanyuan Cai et al.
Bingyi Zhang et al.
Background: The muscle-adipose index (MAI), a novel nutritional parameter for assessing body composition, has emerged as a potential prognostic indicator. This study aimed to research MAI and its longitudinal changes befo...
Antibody-drug conjugate: a newly developed biological missile for tumor treatment [0.03%]
抗体药物偶联物：肿瘤治疗的新型生物导弹
Zhuoran Tang,Yanchun Xie,Yanping Zeng
Zhuoran Tang
Antibody-drug conjugates (ADCs) represent one of the most advanced drug configurations under current research, primarily composed of a monoclonal antibody (mAb), a highly potent cytotoxic payload, and a linker that connects the drug to the ...