Efficacy of brentuximab vedotin combined with sintilimab in relapsed/refractory DLBCL patient with secondary hemophagocytic syndrome: a case report and literature review [0.03%]
布雷卡珠单抗维多汀联合信迪利单抗治疗难治/复发型伴噬血细胞综合征DLBCL患者的有效性：1例报告及文献复习
Siyu Cheng,Huihong Wu,Wenguang Bao et al.
Siyu Cheng et al.
Currently, there is no definitive and effective treatment strategy for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL). In recent years, studies on brentuximab vedotin (BV) and programmed cell death-1 (PD-1) monotherapy for R/...
Identifying clinically relevant findings in breast cancer using deep learning and feature attribution on local views from high-resolution mammography [0.03%]
使用深度学习和特征归因法从高分辨率乳腺X线摄影的局部视图中识别乳腺癌的相关发现
Diego Mellado,Leondry Mayeta-Revilla,Julio Sotelo et al.
Diego Mellado et al.
Introduction: Early detection of breast cancer via mammography screening is essential to improve survival outcomes, particularly in low-resource settings such as the global south where diagnostic accessibility remains lim...
Expression patterns of MRP2 in circulating tumor cells of breast cancer: a single-institution study [0.03%]
乳腺癌循环肿瘤细胞中MRP2的表达模式：单中心研究
Jiayu Guan,Fuping Li,Wenbin Zhou
Jiayu Guan
Background: Breast cancer metastasis remains a major oncology challenge, with circulating tumor cells (CTCs) driving dissemination and multidrug resistance (MDR) hindering treatment efficacy. MRP2, an ABC transporter link...
Diagnostic value of super-resolution ultrasound imaging in differentiating benign and malignant BI-RADS-4 breast lesions [0.03%]
超分辨率超声成像鉴别BI-RADS 4类乳腺良恶性病变的价值
Xueqin Hou,Zhiming Li,Yibin Liu et al.
Xueqin Hou et al.
Objective: Benign and malignant breast tumors exhibit distinct microvascular morphological patterns and spatial distribution characteristics; however, current clinical imaging modalities cannot comprehensively assess thei...
Tong Liu,Tianhua Wu,Lijun Luo et al.
Tong Liu et al.
Sirtuins are a highly conserved family of NAD+-dependent deacetylases involved in regulating critical biological processes such as cell survival, antioxidation, gene transcription, proliferation, differentiation, DNA repair, and mitochondri...
Nomogram model for prognosis of early colorectal cancer after endoscopic therapy: integration of intestinal microbiota and clinicopathological parameters [0.03%]
内镜治疗早期结直肠癌预后预测模型的构建及肠道菌群的影响研究
Yanli Zhu,Fang Yang,Lijun Meng et al.
Yanli Zhu et al.
Objective: To integrate the characteristics of intestinal flora and clinical pathological parameters in patients with early colorectal cancer, and to construct and validate a nomogram model for predicting the prognosis of...
A novel missense mutation c.1381T>C: p.(S461P) in POLE causes multiple molecular features of endometrial carcinoma in China: a case report [0.03%]
POLE新型错义突变c.1381T>C：p.(S461P)导致中国子宫内膜癌患者出现多种分子特征：病例报告
Yingxue Li,Li Wang,Lin Han et al.
Yingxue Li et al.
Background: Accurately determining the pathogenicity of newly discovered POLE mutations is crucial for the precise molecular classification of endometrial carcinoma. ...
XPO1-inhibitor Selinexor induces MGMT expression by activating PKA-CREB signaling in IDH wildtype glioblastoma [0.03%]
XPO1抑制剂Selinexor通过激活PKA-CREB信号通路诱导MGMT表达以治疗IDH野生型胶质母细胞瘤
Josephine A Mapunda,Yuta Suzuki,Danielle Burgenske et al.
Josephine A Mapunda et al.
Purpose: The temozolomide (TMZ) resistance mechanisms in MGMT-promoter methylated IDH wildtype glioblastoma (GBM) tumors are poorly known. This study aimed to identify potential modulators of TMZ resistance in methylated ...
Immunotherapy in conversion therapy for gastric cancer: current status, progress, and challenges [0.03%]
胃癌转化治疗的免疫疗法：现状、进展与挑战
Yi Su,Xin Zhang,Wei Deng
Yi Su
Gastric cancer remains a global health burden due to its late diagnosis and poor prognosis. Conversion therapy aims to make the initially unresectable tumor resectable through systemic treatment, providing the opportunity for long-term surv...
Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study [0.03%]
肺癌腺癌遗传突变与成人BMI关系的回顾性队列研究
Yan Qiao Wu,Lei Yang,Depeng Jiang
Yan Qiao Wu
Background: The impact of obesity on gene mutations in lung adenocarcinoma(ADC) remains unclear. This study investigates the association between Body Mass Index(BMI) and the gene mutation in ADC. ...