Beyond Skin Clearance: Personalized Strategies for DLQI Improvement in Psoriasis -Insights From a Shanghai Prospective Cohort [0.03%]
超越皮肤清除：银屑病DLQI改善的个性化策略——来自上海前瞻性队列的启示
Xin Ma,Quanruo Xu,Le Kuai et al.
Xin Ma et al.
Introduction: Psoriasis is a chronic immune-mediated disease that significantly impacts patients clinically and psychologically. Physician-assessed severity measures, including Psoriasis Area and Severity Index (PASI), Bo...
TYK2 rs34536443 (P1104A) Variant Suppresses ICAM1-Mediated Inflammation: Insights From Mendelian Randomization and Functional Analyses [0.03%]
TYK2 rs34536443(P1104A)变异通过干扰ICAM1介导的炎症抑制作用：孟德尔随机化和功能分析揭示了新机制
Bowen Dai,Ye Tang,Bin Zhang et al.
Bowen Dai et al.
Background: Genetic susceptibility to psoriasis involves multiple loci, including TYK2 (Tyrosine Kinase 2), which is associated with various autoimmune diseases. However, its specific role and mechanisms in psoriasis rema...
Effectiveness and Safety of Tildrakizumab in Elderly and Frail Elderly Psoriatic Patients Up to 2 years [0.03%]
Tildrakizumab治疗老年及高龄银屑病患者的有效性和安全性长达2年
Luca Mastorino,Paolo Dapavo,Martina Burlando et al.
Luca Mastorino et al.
Purpose: Elderly patients with age ≥65 years represent an increasing percentage of the population with moderate-severe psoriasis. The definition of "frail elderly" is not easily framed, generally meaning a patient with u...
Utilization and Costs of Laboratory Monitoring in Biological and Non-Biological Psoriasis Treatment - Large-Scale Claims Data Analysis [0.03%]
生物制剂和非生物制剂治疗银屑病的实验室监测利用及费用分析——大规模保险理赔数据分析
Jan Nicolai Wagner,Kristina Hagenström,Katharina Sophia Müller et al.
Jan Nicolai Wagner et al.
Purpose: Psoriasis vulgaris is a chronic systemic inflammatory disease that imposes a significant physical, emotional, and social burden on affected individuals. There is a growing recognition of the importance of compreh...
Bimekizumab: The First FDA-Approved Dual IL-17A/IL-17F Inhibitor for Plaque Psoriasis - A Comprehensive Literature Review [0.03%]
Bimekizumab：首个获FDA批准的双重IL-17A/IL-17F抑制剂用于斑块状银屑病——全面文献综述
Sukainah Ahmed Al Alshaikh,Zahra Mohammad Almarhoon,Hisham Momattin et al.
Sukainah Ahmed Al Alshaikh et al.
Psoriasis is a chronic inflammatory immune-mediated disease that affects 1-3% of the worldwide population. It is now known that interleukin IL-17F and IL-17A have a role in the pathophysiology of immune-mediated inflammatory disorders, such...
Successful Treatment with Secukinumab in a Psoriasis Patient on Hemodialysis [0.03%]
血透患者使用塞库珠单抗治疗成功案例报告
Yu Xiao,Jingru Sun
Yu Xiao
Moderate to severe psoriasis has been reported as an independent risk factor for IgA nephropathy (IgAN). IgAN is characterized by episodic microscopic hematuria, which can progress to end-stage renal disease (ESRD). Managing therapeutic int...
Update on Erythrodermic Psoriasis: Proposal of a Management Algorithm by an Innovative Severity Evaluation Approach [0.03%]
新型严重度评估方法指导下银屑病红皮病的治疗算法探索及疗效观察
Jia-Ming Xu,Chao Wu,Hao Feng et al.
Jia-Ming Xu et al.
Erythrodermic psoriasis (EP) is an uncommon and severe form of psoriasis, which exhibits a Th1/Th17/TNF inflammatory pattern. Most patients with EP experience systemic symptoms that necessitate systemic treatments. These treatments include ...
Psoriasis Does Not Seem to Impair Glomerular and Tubular Function - The Comprehensive Study on Serum and Urine [0.03%]
银屑病不影响肾小球和肾小管功能-血清及尿液的全面研究
Julia Nowowiejska,Anna Baran,Justyna Magdalena Hermanowicz et al.
Julia Nowowiejska et al.
Introduction: There is a dispute as to whether patients with psoriasis have impaired kidney function. We aimed to assess several recognized and experimental markers of glomerular filtration and tubular function in such pa...
Tobacco Smoking Was Positively Associated with Disease Relapse at week 24 and 48 Among Patients with Psoriasis Vulgaris in Shanghai: A Prospective Study [0.03%]
上海银屑病患者吸烟与第24周和第48周复发有关：一项前瞻性研究
Fanlingzi Shen,Yuning Ding,Yan Qiang et al.
Fanlingzi Shen et al.
Purpose: Tobacco smoking is an unhealthy behavior associated with the onset, severity, and treatment response of psoriasis. However, evidence regarding the impact of tobacco smoking on the relapse of psoriasis remains lim...
Epidemiology and Health Care of Generalized Pustular Psoriasis in Germany - Methodology and Outcomes of Claims Data Analysis [0.03%]
德国泛发性脓疱型银屑病的流行病学和医疗保健： claims数据分析的方法与结果
Kristina Hagenström,Katharina Müller,Nesrine Ben-Anaya et al.
Kristina Hagenström et al.
Purpose: Epidemiological and health care data on generalized pustular psoriasis (GPP) show large differences in literature. This study assessed GPP epidemiology, comorbidities and health care in Germany. ...