Genetic Evidence Linking Immune Cell Subsets to Psoriatic Arthritis Susceptibility: A Mendelian Randomization Study [0.03%]
遗传证据将免疫细胞亚群与银屑病关节炎易感性联系起来的孟德尔随机化研究
Huiwei Wang,Mingxuan Ma,Chenfeng Wang et al.
Huiwei Wang et al.
Introduction: Psoriatic arthritis (PsA) involves intricate immune-mediated pathways that extend beyond the well-characterized IL-23/IL-17 axis. Given that many patients show inadequate responses to current therapies, iden...
Core Differentially Expressed Genes in Psoriasis Lesions: An Integrated Analysis of Four GEO Datasets [0.03%]
银屑病皮损核心差异表达基因的整合分析四个GEO数据集的研究
Mariem Ennouri,Zeliha Görmez,Emna Bahloul et al.
Mariem Ennouri et al.
Purpose: Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation, affecting approximately 2% of the global population. ...
Application of Trichoscopy and Novel Non-Invasive Imaging Techniques in the Diagnosis and Management of Patients with Scalp Psoriasis [0.03%]
毛发镜和新型无创成像技术在头皮银屑病诊断及治疗中的应用
Aleksandra Kuchnicka,Urszula Fałkowska,Piotr Konopelski et al.
Aleksandra Kuchnicka et al.
Scalp psoriasis affects up to 80% of patients with psoriasis and possesses a significant challenge as a difficult-to-treat area. A comprehensive literature search was conducted in PubMed using relevant keywords to identify recent studies fo...
Successful Treatment of Two Rare Pediatric Keratinization Disorders with Secukinumab: Epidermolytic Ichthyosis and PRP-GPP Overlap [0.03%]
塞库利单抗成功治疗两种罕见儿童角化病：板层状鱼鳞病和具有疱疹脓肿表型的基因多态性复发性发热综合征重叠综合症
Qianyue Xu,Jia Zhang
Qianyue Xu
Pediatric erythroderma can arise from either inherited keratin defects or cytokine-driven inflammation, yet evidence for biologic therapies in these settings is limited. We report two rare pediatric cases successfully treated with secukinum...
Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A [0.03%]
吲哚-3-乳酸通过芳烃受体依赖性抑制白细胞介素-17A缓解咪喹莫特诱导的小鼠银屑病皮炎
Zhen Meng,Jieru Ren,Yuhsien Lai et al.
Zhen Meng et al.
Purpose: Psoriasis is a chronic immune-mediated skin disease increasingly linked to skin and gut dysbiosis. Microbiota-derived tryptophan catabolites act as endogenous ligands of the aryl hydrocarbon receptor (AhR) and mo...
Prevalence of Genital Psoriasis and Its Impact on Patients' Sexual Life in Routine Care: Epidemiologic Survey in Germany [0.03%]
德国常规护理中银屑病患者生殖器受累的患病率及其对性生活的影响：流行病学调查
Toni Maria Janke,Christina Sorbe,Rachel Sommer et al.
Toni Maria Janke et al.
Purpose: Psoriatic disease (PsO) involving the genital region (GenPsO) or areas of sexual interest (ASI; anal region, gluteal area, groin, lower back, and chest/breast) is associated with impaired quality of life (QoL), s...
The Psoriatic Disease Assessment Index (PSODAI) Score to Evaluate Systemic Involvement of Psoriasis [0.03%]
银屑病全身损害评估指数(PSODAI评分)
Yanhua Liang,Baoqing Deng,Epipode Ntawuyamara et al.
Yanhua Liang et al.
Background: To the best of our knowledge, no validated scoring instrument currently exists that comprehensively evaluates both cutaneous manifestations and systemic comorbidities of psoriasis. This multicenter study aimed...
Persistence and Long-Term Disease Control of Interleukin-17 Inhibitors and Interleukin-23 Inhibitors in Patients with Psoriasis: A Nationwide Cohort Study in Japan [0.03%]
日本特应性队列研究中的白细胞介素-17抑制剂和白细胞介素-23抑制剂在银屑病患者中的持久性和长期疾病控制能力
Youran Xu,Tong Li,Chia-Ling Chang et al.
Youran Xu et al.
Introduction: Interleukin-17 inhibitors (IL-17i) and interleukin-23 inhibitors (IL-23i) are advanced therapeutic options for moderate-to-severe psoriasis. In real-world settings, biologic persistence is commonly used as a...
Bidirectional Associations Between Substance Abuse and Psoriasis: A Prospective Cohort Study [0.03%]
双向关联：物质滥用与银屑病的前瞻性队列研究
Xuanlin Che,Jiatong Zhou,Anqi Wang et al.
Xuanlin Che et al.
Background: Psoriasis and substance abuse remains a serious healthcare burden. However, associations between substance abuse and psoriasis have not been elucidated. ...
Zeno Fratton,Stefano Bighetti,Luca Bettolini et al.
Zeno Fratton et al.
Introduction: Psoriasis is a chronic inflammatory disease whose burden peaks in older age groups. Despite the increasing prevalence of elderly patients with moderate-to-severe psoriasis, real-world data on biologics in th...