Secukinumab in the treatment of psoriasis: patient selection and perspectives [0.03%]
司库奇尤单抗治疗银屑病的患者选择及展望
Eric J Yang,Kristen M Beck,Wilson Liao
Eric J Yang
Secukinumab is a human monoclonal antibody targeting IL-17A that has been approved for three indications: moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. In Phase III clinical trials for each of these t...
The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA [0.03%]
医师总体评估和体表面积复合工具是银屑病评分的简便替代方法：PRISTINE 和 PRESTA 研究的事后分析
Jessica A Walsh,Heather Jones,Lotus Mallbris et al.
Jessica A Walsh et al.
Background: The product of Physician Global Assessment and Body Surface Area (PGA × BSA) is a new outcome measure for psoriasis severity and response to therapy. The objective of this study was to evaluate PGA × BSA as ...
Evaluation of ADA activity as a potential marker of disease severity in psoriasis patients [0.03%]
评估ADA活性作为银屑病患者疾病严重程度潜在标志物的价值
Seraj Ahmed Khan,Sudha Agrawal,Nirmal Baral et al.
Seraj Ahmed Khan et al.
Background: Psoriasis is a dermatological disorder with a multifactorial origin and is associated with many biochemical and immunological changes. Purpose...
Profile of tildrakizumab-asmn in the treatment of moderate-to-severe plaque psoriasis: evidence to date [0.03%]
有关治疗中至重度斑块状银屑病的 Tildrakizumab-asmn 现有研究证据评述
Kristen M Beck,Isabelle M Sanchez,Eric J Yang et al.
Kristen M Beck et al.
Plaque psoriasis is an immune-mediated skin disease that affects roughly 3% of adults in the United States. Advances over the past 20 years in understanding the immune-mediated pathophysiology of psoriasis have led to the development of tar...
Eric J Yang,Kristen M Beck,Isabelle M Sanchez et al.
Eric J Yang et al.
Psoriasis is a chronic immune-mediated inflammatory disease with significant medical and psychological comorbidities. In addition to having increased cardiovascular risk and mortality, psoriasis patients are more likely to be depressed, anx...
Abatacept for the treatment of adults with psoriatic arthritis: patient selection and perspectives [0.03%]
阿巴西普治疗银屑病性关节炎患者：选择和展望
Ashley Noisette,Marc C Hochberg
Ashley Noisette
Psoriatic arthritis (PsA) is a heterogeneous disease with several clinical subtypes including peripheral arthritis, dactylitis, enthesitis, nail disease, and axial arthritis. Nonsteroidal anti-inflammatory drugs, glucocorticoids, and conven...
Monitoring methotrexate-induced liver fibrosis in patients with psoriasis: utility of transient elastography [0.03%]
甲氨蝶呤致银屑病患者肝纤维化的监测：瞬时弹性成像技术的临床价值评估
Harriet S Cheng,Marius Rademaker
Harriet S Cheng
Increasingly, existing evidence indicates that methotrexate-associated liver injury is related to comorbid risk factors such as diabetes, alcoholism, and obesity, rather than to methotrexate itself. Despite this fact, significant effort con...
Low starting dosage of infliximab with possible escalating dosage in psoriatic arthritis gives the same treatment results as standard dosage of adalimumab or etanercept: results from the nationwide Icelandic ICEBIO registry [0.03%]
依那西普或阿达木单抗标准剂量治疗与英夫利昔单抗低起始剂量且可能增加剂量治疗银屑病关节炎疗效相同：来自冰岛全国性ICEBIO注册中心的数据
Bjorn Gudbjornsson,Arni Jon Geirsson,Niels Steen Krogh
Bjorn Gudbjornsson
Objective: To explore differences in response to a low dosage regimen of infliximab with an escalating dosage in comparison to a standard dosage of etanercept and adalimumab in patients with psoriatic arthritis (PsA). ...
Limited clinical utility of HLA-Cw6 genotyping for outcome prediction in psoriasis patients under ustekinumab therapy: a monocentric, retrospective analysis [0.03%]
乌司奴单抗治疗银屑病患者中HLA-Cw6基因分型的临床应用价值有限：一项单中心回顾性分析
Florian Anzengruber,Adhideb Ghosh,Julia-Tatjana Maul et al.
Florian Anzengruber et al.
Purpose: Several studies have suggested that an HLA-Cw6+ allele can predict an improved outcome of treatment in psoriasis patients. The aim of the study was to assess whether the published association between HLA-Cw6 alle...
Christina Fotiadou,Elizabeth Lazaridou,Eleni Sotiriou et al.
Christina Fotiadou et al.
The recent advances in the understanding of psoriasis pathogenesis have clarified the pivotal role of interleukin (IL)-23. It is a heterodimeric cytokine consisting of two subunits, the unique p19 and the p40, which are shared with IL-12. T...