Evaluating the Role of Disease Duration in Systemic Therapy Response Among Patients with Moderate-to-Severe Psoriasis [0.03%]
中至重度银屑病患者系统治疗反应与病程关系的评估
Min Dai,Yuxiong Jiang,Yujing Xi et al.
Min Dai et al.
Background: Psoriasis is a chronic immune-mediated inflammatory disease. Systemic therapy is usually applicable to patients who have failed topical treatment or phototherapy, but the value of early systemic therapy remain...
Integrated Single-Cell RNA Sequencing and Proteome-Wide Mendelian Randomization Identifies Therapeutic Targets for Psoriasis and Associated Complications [0.03%]
整合单细胞RNA测序和蛋白质组范围的孟德尔随机化识别银屑病及其相关并发症的治疗靶点
Ping Zheng,Yanyun Cao,Ao Wang et al.
Ping Zheng et al.
Background: To identify new targets for protein-based treatments in psoriasis and evaluate the possible negative impacts of these druggable proteins. Meth...
Codon-Usage Bias and Genomic Architecture of 79 Psoriasis-Susceptibility Genes: Implications for Expression Efficiency and Therapeutic Targeting [0.03%]
银屑病易感基因的密码子使用偏移和基因组结构：对表达效率和治疗靶点选择的意义
Shanshan Jiang,Lu Chen,Jianghui Li et al.
Shanshan Jiang et al.
Introduction: Psoriasis is a chronic autoimmune skin disorder with a complex genetic basis. However, the codon usage patterns and nucleotide features of psoriasis-related genes remain unexplored, despite their potential t...
Vunakizumab for Treatment of Acrodermatitis Continua of Hallopeau: A Case Report and Literature Review [0.03%]
乌纳珠单抗治疗虹疱疮样连续性肢端皮炎1例及文献复习
Yi Yao,Yingming Ma,Huajie Zhong et al.
Yi Yao et al.
Acrodermatitis continua of Hallopeau (ACH) is a rare pustular psoriasis subtype, characterized by recurrent sterile pustules on digits, progressive nail deformation and atrophy. ACH is often refractory to different therapeutic modalities, p...
Long-Term Real-World Effectiveness and Drug Survival of Guselkumab in Patients with Psoriasis: A 5-Year Retrospective Study [0.03%]
古塞库单抗治疗银屑病患者长期疗效及用药持续性的真实世界研究：一项5年回顾性研究
Edoardo Mortato,Marina Talamonti,Lorenzo Marcelli et al.
Edoardo Mortato et al.
Background: Clinical trials have demonstrated the efficacy of guselkumab in psoriasis, however, limited data are available from real-life studies evaluating the long-term effectiveness and drug survival (DS) of guselkumab...
Epidemiology of Hypertension in Psoriasis: An Analysis of Trends from 2006 to 2023 [0.03%]
2006至2023年银屑病高血压流行趋势分析
Miao Zhang,Jia-Le Chen,Si-Wei Fan et al.
Miao Zhang et al.
Background: Psoriasis and hypertension (HTN) are known to be closely related. However, at present, no study has systematically examined the epidemiology of this disease pattern on a global scale. ...
Machine Learning-Driven Prediction Models for Brodalumab Therapeutic Effect and Response Speed in Plaque Psoriasis [0.03%]
基于机器学习的预测生物制剂布罗利单抗治疗银屑病疗效及起效速度模型
Lu Peng,Liyang Wang,Ling Chen et al.
Lu Peng et al.
Purpose: Biologic therapies have transformed plaque psoriasis treatment, but patient responses remain variable, neces+sitating machine prediction model for personalized therapy. ...
Biosimilars for the Treatment of Moderate to Severe Chronic Plaque Psoriasis [0.03%]
生物类似药治疗中重度慢性斑块状银屑病
Paolo Gisondi,Francesco Bellinato,Tea Curic et al.
Paolo Gisondi et al.
Psoriasis is an immune-mediated chronic inflammatory skin disease affecting over 60 million adults and children worldwide and can occur at any age, from childhood to adulthood. If the patient has a diffuse form of psoriasis, affecting more ...
The Skin-Brain Axis in Psoriasis and Depression: Roles of Inflammation, Hormones, Neuroendocrine Pathways, Neuropeptides, and the Microbiome [0.03%]
银屑病和抑郁症的皮肤-脑轴：炎症、激素、神经内分泌通路、神经肽和微生物群的作用
Lipeng Tang,Huichang Bi,Kangguang Lin et al.
Lipeng Tang et al.
Psoriasis, a common chronic inflammatory skin disease affecting approximately 2-3% of the global population, frequently co-occurs with depression. This highly prevalent comorbidity significantly impairs patients' quality of life. Despite th...
Causal Effect of Plasma Fatty Acid Profiles on Psoriasis Risk: Genetic Evidence from a Mendelian Randomization Study [0.03%]
基于 mendelian randomization 研究的遗传证据揭示血浆脂肪酸谱对银屑病发病的因果效应
Lei Yao,Xi Wang,Dongmei Lu et al.
Lei Yao et al.
Introduction: Emerging evidence indicates that omega-3 fatty acids from fish oil may serve as beneficial dietary supplements for psoriasis management. Clinical observations demonstrate a significant association between ps...