Inflammaging and Senescence-Associated Secretory Phenotype (SASP) in Psoriasis - A Narrative Review of Potential Mechanisms and Anti-Inflammaging Strategies [0.03%]
银屑病中衰老和衰老相关分泌表型(SASP)的炎症老化机制及抗炎老化的策略——叙述性综述
Kinga Filipek,Julia Nowowiejska-Purpurowicz,Iwona Flisiak
Kinga Filipek
Psoriasis is a common chronic dermatological disease, affecting approximately 1-3% of the global population, and is associated with numerous comorbidities, impaired quality of life, and reduced life expectancy compared with the general popu...
Immunosenescence in Older Patients with Psoriasis: Mechanistic Insights and Opportunities for Biologic Therapy [0.03%]
老年银屑病患者的免疫衰老：机制见解及生物制剂治疗的机会
Wenjie Wang,Shuying Zha,Liyun Sun et al.
Wenjie Wang et al.
Psoriasis is a chronic systemic inflammatory disease that is increasingly seen in older patients. As the immune system ages, the mechanisms that normally keep immune responses in balance become less precise. The adaptive immune system is re...
Development of Predictive Models for NB-UVB Treatment Efficacy and Safety in Psoriasis [0.03%]
用于银屑病NB-UVB治疗有效性和安全性的预测模型的开发
Yingyuan Yu,Bingjie Li,Yu Wang et al.
Yingyuan Yu et al.
Background: Psoriasis is a chronic inflammatory skin disease. Narrow-band ultraviolet B (NB-UVB) phototherapy is an effective, cost-efficient, and safe treatment for plaque psoriasis; however, predictors of treatment resp...
Paraneoplastic Papuloerythroderma of Ofuji Masquerading as Worsening Psoriasis [0.03%]
误诊为恶化银屑病的(Ofuji)肿瘤相关性皮炎1例
Megan Hauptman,Nikhil Mehta,Frank Wang et al.
Megan Hauptman et al.
Paraneoplastic papuloerythroderma of Ofuji (PEO) is a rare cause of exfoliative erythroderma characterized by intensely pruritic, generalized erythema and scale with relative sparing of the skin folds (deck-chair sign) and is frequently ass...
Patient-Reported Well-Being in Value-Based Routine Care in Psoriatic Disease Using Tildrakizumab: 2-Year Data of the Phase IV POSITIVE Study [0.03%]
POSITIVE研究为期两年的价值导向常规照护下的银屑病患者使用Tildrakizumab治疗后的患者报告的生活质量：第四期临床试验数据
Ulrich Mrowietz,Rachel Sommer,Ziad Reguiai et al.
Ulrich Mrowietz et al.
Purpose: Psoriasis extends beyond skin manifestations and significantly impacts patients' psychological health, social interactions, and daily functioning. The main objective was to assess the 2-year effect of tildrakizum...
Genetic Evidence Linking Immune Cell Subsets to Psoriatic Arthritis Susceptibility: A Mendelian Randomization Study [0.03%]
遗传证据将免疫细胞亚群与银屑病关节炎易感性联系起来的孟德尔随机化研究
Huiwei Wang,Mingxuan Ma,Chenfeng Wang et al.
Huiwei Wang et al.
Introduction: Psoriatic arthritis (PsA) involves intricate immune-mediated pathways that extend beyond the well-characterized IL-23/IL-17 axis. Given that many patients show inadequate responses to current therapies, iden...
Core Differentially Expressed Genes in Psoriasis Lesions: An Integrated Analysis of Four GEO Datasets [0.03%]
银屑病皮损核心差异表达基因的整合分析四个GEO数据集的研究
Mariem Ennouri,Zeliha Görmez,Emna Bahloul et al.
Mariem Ennouri et al.
Purpose: Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation, affecting approximately 2% of the global population. ...
Application of Trichoscopy and Novel Non-Invasive Imaging Techniques in the Diagnosis and Management of Patients with Scalp Psoriasis [0.03%]
毛发镜和新型无创成像技术在头皮银屑病诊断及治疗中的应用
Aleksandra Kuchnicka,Urszula Fałkowska,Piotr Konopelski et al.
Aleksandra Kuchnicka et al.
Scalp psoriasis affects up to 80% of patients with psoriasis and possesses a significant challenge as a difficult-to-treat area. A comprehensive literature search was conducted in PubMed using relevant keywords to identify recent studies fo...
Successful Treatment of Two Rare Pediatric Keratinization Disorders with Secukinumab: Epidermolytic Ichthyosis and PRP-GPP Overlap [0.03%]
塞库利单抗成功治疗两种罕见儿童角化病：板层状鱼鳞病和具有疱疹脓肿表型的基因多态性复发性发热综合征重叠综合症
Qianyue Xu,Jia Zhang
Qianyue Xu
Pediatric erythroderma can arise from either inherited keratin defects or cytokine-driven inflammation, yet evidence for biologic therapies in these settings is limited. We report two rare pediatric cases successfully treated with secukinum...
Indole-3-Lactic Acid Attenuates IMQ-Induced Psoriasiform Dermatitis in Mice via AhR-Dependent Suppression of IL-17A [0.03%]
吲哚-3-乳酸通过芳烃受体依赖性抑制白细胞介素-17A缓解咪喹莫特诱导的小鼠银屑病皮炎
Zhen Meng,Jieru Ren,Yuhsien Lai et al.
Zhen Meng et al.
Purpose: Psoriasis is a chronic immune-mediated skin disease increasingly linked to skin and gut dysbiosis. Microbiota-derived tryptophan catabolites act as endogenous ligands of the aryl hydrocarbon receptor (AhR) and mo...