Preparation and In Vitro Characterization of Triamcinolone Acetonide-Loaded Lipid Liquid Crystal Nanocarriers for Ocular Delivery [0.03%]
用于眼部给药的丙酸氯倍他索脂质液晶纳米载体的制备及体外表征
Fatemeh Asgharian Rezae,Malihe Karimi,Hossein Kamali et al.
Fatemeh Asgharian Rezae et al.
Purpose: This study aimed to develop sustained-release triamcinolone acetonide (TA) formulations using lipid liquid crystals (LLCs) for ocular drug delivery and to characterize the designed formulations. ...
Purification of Monoclonal Antibodies Using Chromatographic Methods: Increasing Purity and Recovery [0.03%]
层析方法纯化单克隆抗体：提高纯度和回收率
Elnazalsadat Jafarzadeh Chehraghi,Parvin Akbarzadehlaleh,Karim Shamsasenjan
Elnazalsadat Jafarzadeh Chehraghi
Monoclonal antibodies (mAbs) have gained increasing significance in biopharmaceutical research and production because of their precise targeting and therapeutic potential. The purification of mAbs is a crucial stage in production, ensuring ...
Targeted Delivery of Bortezomib Using Retinoid-Based Nanoparticle: Modulating Liver Fibrosis through the TGF-β1/Smad3 Pathway [0.03%]
视黄醇基纳米粒载硼替佐米靶向给药：通过TGF-β1/Smad3信号通路调控肝纤维化
Samaneh Siapoush,Mohammad Rahmati,Morteza Milani et al.
Samaneh Siapoush et al.
Purpose: Hepatic stellate cells (HSCs) play a crucial role in fibrosis progression. we have developed a targeted delivery approach using A-functionalized nanoparticles for bortezomib (BTZ) specifically for activated HSCs ...
PTEN and p53 Combined Gene Therapy Promote Apoptosis and Chemosensitivity to Oxaliplatin in Colorectal Cancer: An In Vitro Study [0.03%]
PTEN和p53联合基因治疗可促进结直肠癌细胞发生凋亡并增加其对奥沙利铂的敏感性（体外研究）
Narjes Nakhaee,Sirous Zeinali,Mahboubeh Kabiri et al.
Narjes Nakhaee et al.
Purpose: Cancer is a complex condition and gene therapy has evolved as a promising method for cancer treatment. Studies have demonstrated that PTEN and p53 proteins have remarkable antitumor effects but combined up-regula...
Gouty Arthritis Treatment: Advancements in Topical Lipid-Based Nanocarrier Delivery Systems [0.03%]
痛风性关节炎的治疗：基于 topical lipid-based nanocarrier递送系统的进展
Shubham Kumar,Shreya Kaul,Neha Jain et al.
Shubham Kumar et al.
The formation of urate crystals in the joints causes severe, erratic flare-ups of joint pain, swelling, and erythema in gout, one kind of inflammatory arthritis. The standard treatment currently available involves the use of nonsteroidal an...
Fabrication of Chrysin-Loaded Hyaluronic Acid Decorated Niosomal Nanoparticles: Potential Anti-inflammatory and Anti-osteoclastic Effects on PBMCs of Rheumatoid Arthritis Patients [0.03%]
载有白桦醇的透明质酸装饰尼油型纳米粒的制备：对类风湿关节炎患者外周血单个核细胞潜在的抗炎和抗破骨细胞作用
Sarah Nadhim Sahib,Fadhil Jawad Al-Tu&#x;ma,Atheer Hameed Odda et al.
Sarah Nadhim Sahib et al.
Purpose: Rheumatoid arthritis is a persistent autoimmune condition characterized by joint inflammation and degradation, impacting individuals with varying degrees of severity. Chrysin is a natural flavonoid possessing div...
Safety and Feasibility of Blockade of NK Group-2 Member-A Receptor in Natural Killer Cells Combined with Cetuximab Antibody in Patients with Advanced Gastric Adenocarcinoma [0.03%]
针对胃腺癌受试者NK细胞NKG2A受体阻断与西妥昔单抗联合用药的安全性和可行性研究
Maryam Samareh-Salavatipour,Shirin Tavakoli,Maryam Barkhordar et al.
Maryam Samareh-Salavatipour et al.
Purpose: Blocking of inhibitory receptors such as NK group-2 member-A (NKG2A) enhances tumor immunity of natural killer (NK) cells. Additionally, antibody-dependent cellular cytotoxicity (ADCC) is an important cytotoxic m...
A Novel GLP-1 and FGF21 Fusion Protein for the Treatment of Non-alcoholic Steatohepatitis (NASH) [0.03%]
一种治疗非酒精性脂肪肝病(NASH)的GLP-1和FGF21融合蛋白新药
Zhipeng Zhang,Yanqin Ma,Cheng Xie et al.
Zhipeng Zhang et al.
Purpose: The objective of this study was to develop and produce a novel fusion protein that combines GLP-1 (glucagon-like peptide-1) and FGF21 (fibroblast growth factor 21), with the aim of achieving synergistic pharmacol...
Well-regulated Dermal Regeneration Using Amnion-containing Scaffold in a Preclinical Study [0.03%]
含胎盘绒毛膜的支架促进皮肤再生的临床前研究
Masumeh Staji,Arezoo Karamivandishi,Roya Fattahi et al.
Masumeh Staji et al.
Purpose: we investigated the synergistic influence of amnion and keratinocytes on dermal regeneration in mice. Methods: A scaffold deri...
Development of Folic Acid Functionalized Bilosomes for Delivery of Vorinostat to Breast Cancer Cells: Characterization and Cytocidal Effects on MCF-7 and 4T1 Breast Cancer Cell Lines [0.03%]
叶酸修饰的载伏立尼奥司特递药双脂质体的制备及对乳腺癌细胞杀伤作用的研究
Alireza Rashidi,Somayeh Taymouri,Mahboubeh Rostami et al.
Alireza Rashidi et al.
Purpose: Breast cancer is a prevalent form of cancer in woman. Vorinostat (VOR) is a chemotherapeutic drug that has been utilized for treatment of breast cancer, but its effectiveness is limited due to low bioavailability...